Pyrrolizidine Alkaloids from Ligularia sibirica Cass. and Tephroseris integrifolia L.

Abstract

Tussilagine, isotussilagine, neo-tussilagine and neo-isotussilagine were isolated from Ligularia sibirica whereas Tephroseris integrifolia was found to contain senkirkine, otosenine, hydroxysenkirkine and 07-angeloylheliotridine. The structures were determined using spectroscopical methods (GC-MS; NMR).

The evolution of pyrrolizidine alkaloid biosynthesis and diversity in the Senecioneae

“…Marín-Loaiza et al 2007; and in Tephroseris (e.g. Roeder et al 1980b;Suau et al 2002;Christov and Evstatieva 2003;Wiedenfeld et al 2003). The remaining PA groups identified in the Senecioneae are much less frequently encountered and generally occur in phylogenetically isolated taxa.…”

“…and Schenk ssp. gaudinii Roeder and Liu (1991), Hartmann and Witte (1995), Roeder (2000), , Wiedenfeld et al (2003) Tephroseris pierotii (Miq.) Holub.…”

“…Č elak. Smith and Culvenor (1981), Robins (1982), Mattocks (1986), Rizk (1990), Ahmad et al (1994), Hartmann and Witte (1995) Tephroseris elodes , 5, 8, 14, 20, 27, 39, 40, 67 107, 146, 149, 152 178 1, 5, 8, 14, 107 149 20, 27, 39, 40 Robins (1982), Mattocks (1986), Rizk (1990), Ahmad et al (1994), Hartmann and Witte (1995), , Wiedenfeld et al (2003) …”

Orthogonal Analysis Methodology for the Extraction of Polysaccharides from the Root of <i>Rhodiola sachalinensis</i> A. BOR and Evaluation its Hypoglycemic Effects

“…Recently, a number of bioactive components from RS have been reported, including phenylpropanoids, phenylethanol derivatives, flavonoids, monoterpens, triterpenes, phenolic acid and polysaccharides. To date, its biological activities are mainly attributed to phenylethanol derivative salidroside and the phenylpropanoids [1]. However, recent studies have suggested that the polysaccharides from RS (RSPs) also exhibit some biological activities, including antivirus, anti-fatigue, immune enhancing and promote the recovery of hematopoietic function in myelosup-pressed [2].…”

Optimization of Ultrasound-Assisted Extraction of Polysaccharides from the Chinese Medicinal Plant <i>Rhodiola Sachalinensis</i> A. BOR

“…In recent years, studies showed that Rhodiola sachalinensis A. BOR possess a wide range of pharmacologic and health-promoting properties including adaptogenic, antihypoxia, antioxidant, anti-inflammatory, anti-fatigue, antivirus, antidiabetic, anticancer, immune enhancing and sexually stimulating properties [2]. The major bioactive components in the plant are phenylpropanoids (rosavins, rosin); phenylethanol derivatives (salidroside, tyrosol), organic acids, flavonoids, polysaccharides, tannins and phenolic glycosides [3]. To date, its biological activities are mainly attributed to salidroside and the phenylpropanoids.…”