Pyruvate-enhanced cardioprotection during surgery with cardiopulmonary bypass

Olivencia‐Yurvati, Albert H.; Blair, James L.; Baig, Mirza; Mallet, Robert T.

doi:10.1053/j.jvca.2003.09.007

Cited by 39 publications

(41 citation statements)

References 31 publications

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“…In the majority of the studies where protection by pyruvate has been reported, high amounts of sodium pyruvate were administered (500 mg to 2 g/kg, concentrations up to 10 mM) [1,19,[23][24][25][26]. In marked contrast, in the present experiments already 50 mg sodium pyruvate/kg (infused at a rate of 25 mg/kg 3 h) proved to be sufficient to clearly protect the small intestine from ischemia-reperfusion injury.…”

Section: Protection By Low Dosementioning

confidence: 68%

“…In view of this result, the virtually nonexistent toxicity of pyruvate itself, and the already existing clinical experience [23][24][25][26], clinical trials on the effect of sodium pyruvate infusion on the prevention of intestinal ischemia-reperfusion injury, e.g., in a select group of patients undergoing cardiac surgery, are clearly warranted.…”

Section: Perspectivementioning

confidence: 99%

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Protection by Pyruvate Infusion in a Rat Model of Severe Intestinal Ischemia-Reperfusion Injury

Petrat

Rönn

Groot

2011

Journal of Surgical Research

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Section: Protection By Low Dosementioning

confidence: 68%

Section: Perspectivementioning

confidence: 99%

Protection by Pyruvate Infusion in a Rat Model of Severe Intestinal Ischemia-Reperfusion Injury

Petrat

Rönn

Groot

2011

Journal of Surgical Research

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“…Furthermore, some of the glycolytic enzymes identified in the secretome of E. caproni (triose phosphate isomerase and GAPDH) can be implicated in anti-oxidative processes and in the glutathione redox cycle. Pyruvate can detoxify hydrogen peroxide when enzymes normally involved in this process are overwhelmed or absent (Biagini et al 2001;Olivencia-Yurvati et al 2003;Mallet et al 2005). Moreover, NADH generated by glycolysis can be used as an agent to reduce oxidized glutathione accumulated due to GST activity (Tew and Ronai 1999).…”

Section: Resultsmentioning

confidence: 99%

Excretory/secretory proteome of the adult stage of Echinostoma caproni

et al. 2010

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The excretory/secretory proteome of Echinostoma caproni (Trematoda: Echinostomatidae) adults collected from experimentally infected mice was investigated using a proteomic approach. We performed a shot-gun liquid chromatography/tandem mass spectrometry for the separation and identification of tryptic peptides from the excretory/secretory products of E. caproni adult worms. Database search was performed using MASCOT search engine (Matrix-Science) and ProteinPilot software v2.0 (Applied Biosystems). A total of 39 parasite proteins were accurately identified. Strikingly, metabolic enzymes, and particularly glycolytic enzymes, constituted the largest protein family in the excretory/secretory proteome of E. caproni adult worms. Moreover, representative proteins involved in parasite structure, response against stress, chaperones, calcium-binding, and signal transduction were also identified. This work extends our knowledge of host-parasite relationships in the E. caproni-rodent model that is extensively used to analyze the factors determining the intestinal helminth rejection. Consequently, information on many proteins may be useful to better understand the molecular basis that determines the survival of this parasite in the definitive host.

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“…Studies in hemorrhagic shock repeatedly confirmed that Pyr effectively prevented or corrected severe lactic acidosis in swine [6, 34, 41, 42]. A human trial demonstrated that Pyr-fortified cardioplegia solutions provided cardioprotection superior to Lac-based counterparts during surgical cardiac arrest although pHi data were absent [54]. These findings strongly suggested that Pyr was preferable in the correction of intracellular acidosis in both anaerobic and aerobic conditions.…”

Section: Pyruvate Superiority In the Correction Of Acidosismentioning

confidence: 98%

Pyruvate in the Correction of Intracellular Acidosis: A Metabolic Basis as a Novel Superior Buffer

Zhou¹

2005

Am J Nephrol

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The review focuses on biochemical metabolisms of conventional buffers and emphasizes advantages of sodium pyruvate (Pyr) in the correction of intracellular acidosis. Exogenous lactate (Lac) as an alternative of natural buffer, bicarbonate, consumes intracellular protons on an equimolar basis, regenerating bicarbonate anions in plasma while the completion of gluconeogenesis and/or oxidation occurs via tricarboxylic-acid cycle in mitochondria mainly in liver and kidney, or heart. The general assumption that Lac is ‘metabolized to bicarbonate’ in liver to serve as a buffer has been questioned. Pyr as a novel buffer would be superior to conventional ones in the correction of metabolic acidosis. Several likely biochemical mechanisms of Pyr action are discussed. Experimental evidence, in vivo, strongly suggested that Pyr would be particularly efficient in the correction of severe acidemia: type A lactic acidosis, hypercapnia with cardiac arrest, and diabetic and alcoholic ketoacidosis in animal experiments and clinic settings. Because of its multi-cytoprotection, Pyrs not only correct acidosis, but also benefit theunderlying dysfunction of vital organs. In addition, Pyr is also a potential buffer component of dialysis solutions. However, the instability of Pyr in aqueous solutions restricts its clinical applications as a therapeutic agent. Attempts to create a stable Pyr preparation are needed.

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Pyruvate-enhanced cardioprotection during surgery with cardiopulmonary bypass

Cited by 39 publications

References 31 publications

Protection by Pyruvate Infusion in a Rat Model of Severe Intestinal Ischemia-Reperfusion Injury

Protection by Pyruvate Infusion in a Rat Model of Severe Intestinal Ischemia-Reperfusion Injury

Excretory/secretory proteome of the adult stage of Echinostoma caproni

Pyruvate in the Correction of Intracellular Acidosis: A Metabolic Basis as a Novel Superior Buffer

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