Q Fever Associated with Persistent Fever: An Immunologic Disorder?

Garcia-Alfranca, F; Clemente-Rodriguez, C.; Pigrau-Serrallach, Carlos; Fonollosa-Plà, Vicent; Vilardell‐Tarrés, Miquel

doi:10.1093/clinids/18.1.122

Cited by 10 publications

(2 citation statements)

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“…He demonstrated delayed defervescence, remaining febrile 10 days after restarting the drug, which is not uncommon in Q fever hepatitis. 11 Steroid therapy is an option for patients with prolonged pyrexia, as the elevated temperatures may be immunologic. 11,12 Although the pathophysiology of delayed defervescence in Q fever hepatitis is unclear, patients with liver involvement have higher levels of tumor necrosis factor and interleukin-10 in comparison to those with fever alone.…”

Section: Managementmentioning

confidence: 99%

“…11 Steroid therapy is an option for patients with prolonged pyrexia, as the elevated temperatures may be immunologic. 11,12 Although the pathophysiology of delayed defervescence in Q fever hepatitis is unclear, patients with liver involvement have higher levels of tumor necrosis factor and interleukin-10 in comparison to those with fever alone. 13 Ultimately, this patient's fevers and elevated transaminases improved, and he was discharged home on doxycycline.…”

Section: Managementmentioning

confidence: 99%

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Prolonged Pyrexia and Hepatitis: Q fever

Dugdale

Chow

Yakirevich

et al. 2014

The American Journal of Medicine

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Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Prolonged Pyrexia and Hepatitis: Q fever

Dugdale

Chow

Yakirevich

et al. 2014

The American Journal of Medicine

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Steroids treatment of granulomatous hepatitis complicatingCoxiella burnetii acute infection

et al. 1999

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Granulomatous hepatitis associated with Coxiella burnetii acute infection has an adverse clinical course in some patients. Surprisingly, it does not respond to antibiotic but to steroids treatment. A hypersensitivity mechanism has been implicated. A case of granulomatous hepatitis complicating C. burnetii acute infection is reported, which was refractory to antibiotics but, as in four other cases previously reported, showed a complete response to steroids. This case was found to support findings that moderate doses of steroids can be useful in patients with granulomatous hepatitis complicating C. burnetii infection and showing no response to antibiotic treatment.

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Q Fever Endocarditis: Does Serology Predict Outcome?

Alarcón

2012

Curr Infect Dis Rep

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Q fever is an ubiquitous zoonosis caused by Coxiella burneti, an intracellular bacterium that can produce acute or chronic infections in humans. These forms are characterized by different evolution, serological profile and treatment that must be very long to achieve a cure in chronic forms. However, the serological profile for diagnosis and the real value of serology for predicting outcome are controversial, and management dilemmas for many patients with Q fever infection are continuously emerging. In this article, we describe in a comprehensive manner the different clinical presentations of the disease, making a critical overview of the evidence for serological predictions. We also take a broad view of new available diagnostic techniques and finally, we give recommendations for treatment.

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Q Fever Associated with Persistent Fever: An Immunologic Disorder?

Cited by 10 publications

References 0 publications

Prolonged Pyrexia and Hepatitis: Q fever

Prolonged Pyrexia and Hepatitis: Q fever

Steroids treatment of granulomatous hepatitis complicatingCoxiella burnetii acute infection

Q Fever Endocarditis: Does Serology Predict Outcome?

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