Background: Qigong, traditional Chinese mind-body practices, is currently receiving increasing attention with exploration of what it is and what it does. Common elements include postures and movement, attention to breathing, and mental instructions. There is a growing literature on the health benefits of qigong in chronic pain and other conditions, and an intervention that provides benefit in multiple domains is particularly important for clinical practice. In this report, we present a case series of six individuals who engaged in extended qigong practice over the course of at least 4 and up to 11 years, with data derived from an observational trial which evaluated effects of qigong practice on pain, mood, sleep, fatigue, quality of life and overall health in patients attending an outpatient pain management clinic. Methods: Participants attended weekly qigong classes as a voluntary, complementary practice for chronic pain management, and were encouraged to practice regularly at home. Qualitative data were collected prospectively over a series of sessions. Participant narratives were reviewed and those with extended practice histories were included in our case series. Results: Qualitative commentary reflected the richness and heterogeneity of benefits achieved in all studied health domains. Three primary themes were identified: 1) Direct benefits of qigong practice include improvements in pain, pain control, sleep, and other health areas; 2) Regular qigong practice improves quality of life, increases energy and activity, improves mood, and decreases use of medications; 3) Qigong practice cultivates an improved outlook on life and the future as an overall effect. Conclusions: This case series reveals multiple health benefits of extended qigong practice. Given that these occurred in those who practiced the most, one of the barriers to potential health benefits achieved by qigong is commitment to the practice. In appropriate circumstances, health care professionals can recommend qigong as a complementary practice for successful chronic pain management.