Qingjin Yiqi granules for post‐COVID‐19 condition: A randomized clinical trial

Pang, Wentai; Yang, Fengwen; Zhao, Yubin; Dai, Erfu; Feng, Jiashi; Huang, Yu-Hong; Guo, Yongming; Zhou, Shengyuan; Huang, Ming; Wang, Zheng; Ma, Jiang; Li, Hong; Li, Qing; Hou, Lijuan; Zhang, Shuo; Wang, Hui; Liu, Qingquan; Zhang, Boli; Zhang, Junhua

doi:10.1111/jebm.12465

Cited by 25 publications

(24 citation statements)

References 30 publications

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“…In the study of Pang et al ( 22 ) the patients used the Borg scale ( 39 ) to grade the level of their fatigue. This is a scale ranging from 0 = nothing at all to 20 = very, very severe (maximal).…”

Section: Resultsmentioning

confidence: 99%

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Post-COVID-19 fatigue: A systematic review

Joli¹,

Buck²,

Zipfel³

et al. 2022

Front. Psychiatry

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Fatigue is recognized as one of the most commonly presented long-term complaints in individuals previously infected with SARS-CoV-2. This systematic review was performed to describe symptoms, etiology, possible risk factors related to post-COVID-19 fatigue and the therapeutic approaches used for the treatment of post-COVID-19 fatigue. For the systematic literature search the databases PubMed, Web of Science, Cochrane Library, and PsycInfo were used. All articles that met the inclusion criteria were analyzed for demographics, clinical data and treatment. Included were studies which focused on an adult population (18–65 years old); elderly patients and patients with chronic somatic diseases which can also cause fatigue were excluded. We identified 2,851, screened 2,193 and finally included 20 studies with moderate to high methodological quality, encompassing 5,629 participants. Potential risk factors for post-COVID-19 fatigue were old age, female sex, severe clinical status in the acute phase of infection, a high number of comorbidities, and a prediagnosis of depression/anxiety. Lastly, a possible autoimmune etiology was suspected. Several treatment approaches have been tested mostly in small and uncontrolled studies so far: a Chinese herbal formulation improved breathlessness and fatigue. Moreover, molecular hydrogen (H2) inhalation had beneficial health effects in terms of improved physical (6-min walking test) and respiratory function in patients with post-COVID-19. Patients also noticed improvement in fatigue after undergoing hyperbaric oxygen therapy (HBOT) and enhanced external counterpulsation (EECP). Lastly. muscle strength and physical function were improved after undergoing an 8-weeks biweekly physical therapy course including aerobic training, strengthening exercises, diaphragmatic breathing techniques, and mindfulness training. However, larger and controlled studies e.g., investigating the effect of physical and / or psychotherapy for patients with post-COVID-19 fatigue are urgently warranted.Systematic Review RegistrationUnique Identifier: CRD42022320676, https://www.crd.york.ac.uk/PROSPERO/.

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Section: Resultsmentioning

confidence: 99%

“…Pang et al ( 22 ) used a drug called Qingjin Yiqi granules (QJYQ) for 388 patients with post-COVID-19 fatigue for 14 days. QJYQ contains 16 herbs.…”

Section: Resultsmentioning

confidence: 99%

Post-COVID-19 fatigue: A systematic review

Joli¹,

Buck²,

Zipfel³

et al. 2022

Front. Psychiatry

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“…TCM can effectively relieve STC in patients. A randomized controlled trial (RCT) that recruited 388 discharged patients with COVID-19 showed that Qingjin Yiqi granules can improve the STC, in the improved scores of the modified Medical Research Council scale (mMRC) and the Borg scale [ 45 ] . An RCT including 131 convalescent patients showed the evidence that Bufei Huoxue capsule improved the attenuation of pneumonia lesions on chest computed tomography (CT), 6-minute walk distance, and fatigue assessment inventory (FAI) scale [ 46 ] .…”

Section: Interventions For Post Covid-19 Stcmentioning

confidence: 99%

Post COVID-19 burden: focus on the short-term condition

Yang

Pang

Jin

et al. 2022

Acupuncture and Herbal Medicine

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The catastrophic pandemic of the coronavirus disease 2019 has caused serious harm to human life and global social economy. As of June 13, 2022, there were more than 530 million confirmed cases of COVID-19 and over 6.3 million deaths [1] . During the past 2 years, global studies on prevention and therapies for COVID-19 have achieved a series of promising findings, including antiviral drugs (Remdesivir, Molnupiravir, Paxlovid) and monoclonal antibodies (Bamlanivimab and Etesevimab, Sotrovimab, Casirivimab and Imdevimab) [2] . World Health Organization (WHO) has validated 11 vaccines for the emergency use listing (EUL) [3] . As of June 13, 2022, more than 11.9 billion vaccine doses have been administered worldwide [1] . In China, integrated using of traditional Chinese medicine (TCM) and Western medicine is one of the highlights in fighting COVID-19. "Three formulations and three drugs" (Jinhua Qinggan granules, Lianhua Qingwen capsule, Xuebijing injection, and Qingfei Paidu decoction, Huashi Baidu decoction, Xuanfei Baidu decoction) have been approved by National Medical Products Administration (NMPA) as new drugs or adding indications for COVID-19 [4] . The new drugs and vaccines had become effective weapons in the fight against the pandemic.

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“…A correct system-based history taking and a detailed physical examination will be the starting point of our study. The use of simple scales, such as the Borg or mMRC, will take minimal time and help to quantify the situation 43 , 44 . As a rule, the routine complementary tests performed in these patients are usually normal and show no evidence of organ involvement: lung X-rays and CT scans, echocardiography, and even NT-ProBNP levels do not usually provide pathological findings in persistent patients.…”

Section: Long-term Cardiac Manifestations: Long Covidmentioning

confidence: 99%