Qingre Lishi Decoction ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice by regulating the Treg-DC-Th17 axis and inhibiting MAPK-mediated DC maturation

Zhu, Xia; Xu, Qingqing; Cao, Zhiqiang; Li, Mingming; Wei, Jingjing; Du, Lin; Han, Changyu; Zhang, Chunhong

doi:10.1016/j.jep.2023.116931

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…For example, previous studies in which metformin was applied to the MAPK and mTOR pathways showed the significant inhibition of cell proliferation and inflammatory responses in human immortalized keratinocytes [239,240]. In view of this, it is not difficult to predict that various natural products that act on the MAPK pathway will show significant psoriasis treatment effects, and consistent progress and multiple previous studies have reported this [241,242]. Several recent studies on the mTOR signaling pathway have identified it as an important regulatory target for the treatment of the epidermal and functional structure in dermatologic diseases, including psoriasis, and relatedly, there are reports that natural products that can modulate this signaling pathway have shown good efficacy in ameliorating animal models of psoriasis with dyslipidemia [243,244].…”

Section: The Key Therapeutic Targets and Pathways Associated With The...mentioning

confidence: 67%

Efficacy and Key Materials of East Asian Herbal Medicine Combined with Conventional Medicine on Inflammatory Skin Lesion in Patients with Psoriasis Vulgaris: A Meta-Analysis, Integrated Data Mining, and Network Pharmacology

Kim

Baek³

et al. 2023

Pharmaceuticals

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Psoriasis is a chronic inflammatory disease that places a great burden on both individuals and society. The use of East Asian herbal medicine (EAHM) in combination with conventional medications is emerging as an effective strategy to control the complex immune-mediated inflammation of this disease from an integrative medicine (IM) perspective. The safety and efficacy of IM compared to conventional medicine (CM) were evaluated by collecting randomized controlled trial literature from ten multinational research databases. We then searched for important key materials based on integrated drug data mining. Network pharmacology analysis was performed to predict the mechanism of the anti-inflammatory effect. Data from 126 randomized clinical trials involving 11,139 patients were used. Compared with CM, IM using EAHM showed significant improvement in the Psoriasis Area Severity Index (PASI) 60 (RR: 1.4280; 95% CI: 1.3783–1.4794; p < 0.0001), PASI score (MD: −3.3544; 95% CI: −3.7608 to −2.9481; p < 0.0001), inflammatory skin lesion outcome, quality of life, serum inflammatory indicators, and safety index of psoriasis. Through integrated data mining of intervention data, we identified four herbs that were considered to be representative of the overall clinical effects of IM: Rehmannia glutinosa (Gaertn.) DC., Isatis tinctoria subsp. athoa (Boiss.) Papan., Paeonia × suffruticosa Andrews, and Scrophularia ningpoensis Hemsl. They were found to have mechanisms to inhibit pathological keratinocyte proliferation and immune-mediated inflammation, which are major pathologies of psoriasis, through multiple pharmacological actions on 19 gene targets and 8 pathways in network pharmacology analysis. However, the quality of the clinical trial design and pharmaceutical quality control data included in this study is still not optimal; therefore, more high-quality clinical and non-clinical studies are needed to firmly validate the information explored in this study. This study is informative in that it presents a focused hypothesis and methodology for the value and direction of such follow-up studies.

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Section: The Key Therapeutic Targets and Pathways Associated With The...mentioning

confidence: 67%

Efficacy and Key Materials of East Asian Herbal Medicine Combined with Conventional Medicine on Inflammatory Skin Lesion in Patients with Psoriasis Vulgaris: A Meta-Analysis, Integrated Data Mining, and Network Pharmacology

Kim

Baek³

et al. 2023

Pharmaceuticals

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“…It is crucial to consider that psoriasis keratinocytes display resistance to signals transmitted by TNF-α, resulting in an elevated concentration of TNF-α in skin alterations and serum among psoriasis patients [ 13 , 14 ]. This resistance prompted the use of TNF-α inhibitors in the therapy of moderate and acute psoriasis, with adalimumab being one such inhibitor known for its ability to bind and deactivate both the membrane and soluble forms of TNF-α [ 15 ]. As per the 2020 guidelines from the Polish Dermatological Society, adalimumab is endorsed for addressing moderate and severe instances of plaque psoriasis and psoriatic arthritis.…”

Section: Introductionmentioning

confidence: 99%

“…In psoriasis, p38 MAPK is activated in keratinocytes and immune cells, leading to the production of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) [ 14 ]. Moreover, Zhu et al suggest that the introduction of a new class of drugs affecting the p38 MAPK pathway may overcome the current failures in the treatment of psoriasis [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Expression profile of mRNAs and miRNAs related to mitogen-activated kinases in HaCaT cell culture treated with lipopolysaccharide a and adalimumab

Wójcik,

Plata-Babula,

Głowaczewska

et al. 2024

Cell Cycle

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Studies indicate that mitogen-activated protein kinases (MAPKs) exhibit activation and overexpression within psoriatic lesions. This study aimed to investigate alterations in the expression patterns of genes encoding MAPKs and microRNA (miRNA) molecules that potentially regulate their expression in human adult low-calcium high-temperature (HaCaT) keratinocytes when exposed to bacterial lipopolysaccharide A (LPS) and adalimumab. HaCaT cells underwent treatment with 1 µg/mL LPS for 8 hours, followed by treatment with 8 µg/mL adalimumab for 2, 8, or 24 hours. Untreated cells served as controls. The molecular analysis involved microarray, quantitative real-time polymerase chain reaction (RTqPCR), and enzyme-linked immunosorbent assay (ELISA) analyses. Changes in the expression profile of seven mRNAs: dual specificity phosphatase 1 ( DUSP1) , dual specificity phosphatase 3 ( DUSP3) , dual specificity phosphatase 4 ( DUSP4) , mitogen-activated protein kinase 9 ( MAPK9) , mitogen-activated protein kinase kinase kinase 2 ( MAP3K2) , mitogen-activated protein kinase kinase 2 ( MAP2K2), and MAP kinase-activated protein kinase 2 (MAPKAPK2 , also known as MK2) in cell culture exposed to LPS or LPS and the drug compared to the control. It was noted that miR-34a may potentially regulate the activity of DUSP1 , DUSP3 , and DUSP4 , while miR-1275 is implicated in regulating MAPK9 expression. Additionally, miR-382 and miR-3188 are potential regulators of DUSP4 levels, and miR-200-5p is involved in regulating MAPKAPK2 and MAP3K2 levels. Thus, the analysis showed that these mRNA molecules and the proteins and miRNAs they encode appear to be useful molecular markers for monitoring the efficacy of adalimumab therapy.

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Based on UPLC-Q-TOF/MS and Network Pharmacology to Explore the Mechanism of Qingre Lishi Decoction in the Treatment of Psoriasis

Wei,

Liu,

et al. 2024

DDDT

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Qingre Lishi Decoction ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice by regulating the Treg-DC-Th17 axis and inhibiting MAPK-mediated DC maturation

Cited by 3 publications

References 40 publications

Efficacy and Key Materials of East Asian Herbal Medicine Combined with Conventional Medicine on Inflammatory Skin Lesion in Patients with Psoriasis Vulgaris: A Meta-Analysis, Integrated Data Mining, and Network Pharmacology

Efficacy and Key Materials of East Asian Herbal Medicine Combined with Conventional Medicine on Inflammatory Skin Lesion in Patients with Psoriasis Vulgaris: A Meta-Analysis, Integrated Data Mining, and Network Pharmacology

Expression profile of mRNAs and miRNAs related to mitogen-activated kinases in HaCaT cell culture treated with lipopolysaccharide a and adalimumab

Based on UPLC-Q-TOF/MS and Network Pharmacology to Explore the Mechanism of Qingre Lishi Decoction in the Treatment of Psoriasis

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