qNMR quantification of phenolic compounds in dry extract of Myrcia multiflora leaves and its antioxidant, anti-AGE, and enzymatic inhibition activities

Oliveira, Edinilze S.C.; Pontes, Flávia Lada Degaut; Acho, Leonard Domingo Rosales; Rosário, Alessandro Silva do; Silva, Bárbara Janaína P. da; Bezerra, Jaqueline de Araújo; Campos, Francinete Ramos; Lima, Émerson Silva; Machado, Marcos B.

doi:10.1016/j.jpba.2021.114109

Cited by 17 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antidiabetic effects were demonstrated for guaijaverin from the extract of Myrcia multiflora in which aldose reductase and α‐glucosidase inhibition were observed 61 . Anti‐advanced glycation end‐products and antioxidant activities corroborated the antidiabetic potential of this compound 46 …”

Section: Resultsmentioning

confidence: 77%

“…In another study, the authors using the same mobile phase showed similar behavior in the analysis of compounds present in Myrcia multiflora (Lam.) DC leaves with the flavonoids guaijaverin (7), quercitrin (11), myricitrin (14), and hyperin (15) 46 …”

Section: Resultsmentioning

confidence: 99%

“…DC leaves with the flavonoids guaijaverin (7), quercitrin (11), myricitrin (14), and hyperin (15). 46 In this work, in addition to the annotation made from the GNPS platform and the confirmation of the identity of the metabolite conducted by spectral prediction (CFM-ID), the standards kaempferol, quercetin, dihydroquercetin, and rutin were used. For kaempferol, the…”

Section: No Referencementioning

confidence: 99%

“…61 Anti-advanced glycation end-products and antioxidant activities corroborated the antidiabetic potential of this compound. 46…”

Section: Quercetin-3-o-pentosidementioning

confidence: 99%

See 3 more Smart Citations

Four almost unexplored species of Brazilian Connarus (Connaraceae): Chemical composition by ESI‐QTof‐MS/MS–GNPS and a pharmacologic potential

Paim

Santos

Toledo

et al. 2021

Phytochemical Analysis

View full text Add to dashboard Cite

Introduction Species of Connaraceae are globally used in traditional medicines. However, several of these have not been studied regarding their chemical composition, and some are even at risk of extinction without proper studies. Therefore, the chemical composition and pharmacological potential of Connarus blanchetii Planch., Connarus nodosus Baker, Connarus regnellii G. Schellenb., and Connarus suberosus Planch., which were previously unknown, were analyzed. Objective This work aims to investigate the pharmacological potential of these four Connarus species. The chemical composition of different extracts was determined by high‐resolution mass spectrometry (HRMS), with subsequent analysis by the GNPS platform and competitive fragmentation modeling (CFM). Materials and methods Leaf extracts (C. blanchetii, C. nodosus, C. regnellii, and C. suberosus) and bark extracts (C. regnellii and C. suberosus) were obtained by decoction, infusion, and maceration. LC/HRMS data were submitted to the GNPS platform and evaluated using CFM in order to confirm the structures. Results The HRMS–GNPS/CFM analysis indicated the presence of 23 compounds that were mainly identified as phenolic derivatives from quercetin and myricetin, of which 21 are unedited in the Connarus genus. Thus, from the analyses performed, we can identify different compounds with pharmacological potential, as well as the most suitable forms of extraction. Conclusion Using HRMS–GNPS/CFM, 21 unpublished compounds were identified in the studied species. Therefore, our combination of data analysis techniques can be used to determine their chemical composition.

show abstract

Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Section: No Referencementioning

confidence: 99%

“…61 Anti-advanced glycation end-products and antioxidant activities corroborated the antidiabetic potential of this compound. 46…”

Section: Quercetin-3-o-pentosidementioning

confidence: 99%

See 2 more Smart Citations

Four almost unexplored species of Brazilian Connarus (Connaraceae): Chemical composition by ESI‐QTof‐MS/MS–GNPS and a pharmacologic potential

Paim

Santos

Toledo

et al. 2021

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

“…Since the 1970s, the commercialization of pulsed Fourier transform NMR spectroscopy, advances in high-field magnets, pulse trains, and cryo probe techniques have led to significant improvements in the sensitivity and resolution of NMR quantitative analysis methods [ 3 ]. At present, NMR technology is increasingly widely used in the fields of food science [ 4 , 5 , 6 ], medicine and health [ 7 , 8 , 9 , 10 , 11 ], organic chemistry [ 12 ], metabolomics [ 13 , 14 , 15 ], animal and plant microbes [ 16 , 17 ], and natural products [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Research Progress of NMR in Natural Product Quantification

Wang

You

et al. 2021

Molecules

View full text Add to dashboard Cite

In the fields of medicine and health, traditional high-performance liquid chromatography or UV-visible spectrophotometry is generally used for substance quantification. However, over time, nuclear magnetic resonance spectroscopy (NMR) has gradually become more mature. Nuclear magnetic resonance spectroscopy has certain advantages in the quantitative analysis of substances, such as being nondestructive, having a high flux and short analysis time. Nuclear magnetic resonance spectroscopy has been included in the pharmacopoeiae of various countries. In this paper, the principle of nuclear magnetic resonance spectroscopy and the recent progress in the quantitative study of natural products by NMR are reviewed, and its application in the quantitative study of natural products is proposed. At the same time, the problems of using NMR alone to quantify natural products are summarized and corresponding suggestions are put forward.

show abstract

Quantification of Two Sulfide Compounds in Oleo–Gum‐Resin Supplement of Ferula foetida Using qH NMR and GC–MS Methods

Eghbali,

Iranshahi,

Rezaee

et al. 2024

Flavour & Fragrance J

View full text Add to dashboard Cite

Asafoetida is an oleo–gum‐resin mainly obtained from Ferula foetida in eastern Iran, which is employed for the treatment of stomachaches, acid reflux, nervous system disorders and respiratory diseases. Asafoetida has attracted the attention of researchers due to its sulfide compounds and their proven effects on respiratory illnesses. In this study, the shelf stability of supplement of F. foetida's oleo–gum‐resin by quantifying two key sulfide compounds including E/Z‐sec‐butyl propenyl disulfane and E/Z‐(methylthio)propyl 1‐propenyl disulfane was evaluated by 1H NMR (qH NMR) and gas chromatography–mass spectrometry (GC–MS). The similar results were obtained in both qH NMR and GC–MS methods. The qH NMR method showed good linearity in the ranges of 2–12 mg/mL for E/Z‐sec‐butyl propenyl disulfane and 2.2–17 mg/mL for E/Z‐(methylthio) propyl 1‐propenyl disulfane with a correlation coefficient of 0.99 and acceptable stability (RSD% ≤ 2.72%) for the quantification of the compounds. Therefore, despite the volatility of disulfide compounds and according to the results, the qH NMR method could be considered adequate method for quantifying these compounds in supplements containing the volatile components that requires extra extraction steps before analyses by other method.

show abstract

qNMR quantification of phenolic compounds in dry extract of Myrcia multiflora leaves and its antioxidant, anti-AGE, and enzymatic inhibition activities

Cited by 17 publications

References 25 publications

Four almost unexplored species of Brazilian Connarus (Connaraceae): Chemical composition by ESI‐QTof‐MS/MS–GNPS and a pharmacologic potential

Four almost unexplored species of Brazilian Connarus (Connaraceae): Chemical composition by ESI‐QTof‐MS/MS–GNPS and a pharmacologic potential

Research Progress of NMR in Natural Product Quantification

Quantification of Two Sulfide Compounds in Oleo–Gum‐Resin Supplement of Ferula foetida Using qH NMR and GC–MS Methods

Contact Info

Product

Resources

About