QT Indexes in Cirrhotic Patients: Relationship with Clinical Variables and Potential Diagnostic Predictive Value

Tuttolomondo, Antonino; Buttà, Carmelo; Casuccio, Alessandra; Raimondo, Domenico Di; Serio, Antonia; D'Aguanno, Gisella; Pecoraro, Rosaria; Renda, Chiara; Giarrusso, Lucia; Miceli, Giuseppe; Cirrincione, Anna; Pinto, Antonio

doi:10.1016/j.arcmed.2015.03.008

Cited by 5 publications

(6 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[13][14][15] QT indexes are altered in cirrhotic patients and have a potential diagnostic predictive value. 16 In our study, although within normal limits, a statistically significant prolongation of QTc interval was shown in patients with compensated cirrhosis compared to the control group. The lack of overcoming of the pathological limits of QTc was thought to be due to the patients' good functional capacity and cardiomyopathy not being yet developed.…”

Section: Discussioncontrasting

confidence: 46%

Association of Cirrhosis and Cardiomyopathy

Sezgin

Cindoğlu

Uyanıkoğlu

et al. 2019

Euroasian Journal of Hepato-Gastroenterology

View full text Add to dashboard Cite

Introduction:We investigated association of pro-BNP, troponin-I, electrocardiography (ECG) and echocardiography (ECHO) during diagnosis and identification of cirrhotic cardiomyopathy in cirrhotic patients. Materials and methods: Patients were divided into three groups as; compensated cirrhotic patients (group 1, n= 30), decompensated cirrhotic (group 2, n = 30) and control group (group 3, n = 30). ECHO, and ECG were performed, and troponin-I and levels of pro-BNP were analyzed. Results: Average age of group 1 was 46.36 ± 16 years (range 19-86), 60% were female; group 2 was 57.03 ± 13.54 years (range 22-89), 56% female; and group 3 was 49.13 ± 0.95 years (range 18-80), 56% female. A significant increase in QTc was detected in compensated cirrhotic patients compared to the control group (p <0.05). Pro-BNP levels were significantly higher (p <0.05) in the compensated cirrhotic group compared to the control group. The levels of pro-BNP were also significantly higher in the decompensated cirrhotic group compared compensated cirrhosis group and control group (p <0.001). Conclusion:The increase of pro-BNP levels with severity of the disease in cirrhotic patients and the prolongation of QTc interval supports an association between these factors with cardiomyopathy.

show abstract

Section: Discussioncontrasting

confidence: 46%

Association of Cirrhosis and Cardiomyopathy

Sezgin

Cindoğlu

Uyanıkoğlu

et al. 2019

Euroasian Journal of Hepato-Gastroenterology

View full text Add to dashboard Cite

show abstract

“…Herein we found that both dQT and dQTc were more prolonged in patients with cirrhosis. One previous study has shown that QT and dQt is prolonged in patients with cirrhosis[ 29 ], while another study shown that QT, but not dQT, is prolonged in patients with alcoholic cirrhosis in comparison with controls[ 30 ]. In contrast, in another study, no differences were found in dQT between patients with cirrhosis and controls[ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity

Tsiompanidis

Siakavellas

Tentolouris

et al. 2018

WJGP

View full text Add to dashboard Cite

AIMTo examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy (CAN).METHODSA total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram recordings were obtained and QT as well as corrected QT interval (QTc) and their dispersions (dQT, dQTc) were measured and calculated using a computer-based program. The diagnosis of CAN was based upon the battery of the tests proposed by Ewing and Clarke and the consensus statements of the American Diabetes Association. CAN was diagnosed when two out of the four classical Ewing tests were abnormal.RESULTSQT, QTc and their dispersions were significantly longer (P < 0.01) in patients with cirrhosis than in controls. No significant differences in QT interval were found among the subgroups according to the etiology of cirrhosis. Multivariate regression analysis after controlling for age, gender and duration of cirrhosis demonstrated significant association between QT and presence of diabetes mellitus [standardized regression coefficient (beta) = 0.45, P = 0.02] and treatment with diuretics (beta = 0.55, P = 0.03), but not with the Child-Pugh score (P = 0.54). Prevalence of CAN was common (54.9%) among patients with cirrhosis and its severity was associated with the Child-Pugh score (r = 0.33, P = 0.02). Moreover, patients with decompensated cirrhosis had more severe CAN that those with compensated cirrhosis (P = 0.03). No significant association was found between severity of CAN and QT interval duration.CONCLUSIONPatients with cirrhosis have QT prolongation. Treatment with diuretics is associated with longer QT. CAN is common in patients with cirrhosis and its severity is associated with severity of the disease.

show abstract

“…14 While abnormal QTc dispersion, in general, can be seen as an early marker of myocardial damage, patients with decompensated cirrhosis often have increased QTc dispersion possibly related to their cardiovascular impairment. 14,71 Chronotropic incompetence means that cirrhotic patients cannot adequately increase their heart rate in response to different stimuli, such as exercise or drugs, contributing to the limited increase of cardiac output and exercise capacity. 1 When contractility is compromised, heart rate has an important contribution to cardiac output, which cannot adequately adapt to stress or effort.…”

Section: Electrophysiological Abnormalitiesmentioning

confidence: 99%

Cirrhotic Cardiomyopathy—A Veiled Threat

Scărlătescu

Марченко

Tomescu

2020

Cardiology in Review

View full text Add to dashboard Cite

Cirrhotic cardiomyopathy (CCM) is defined as cardiac dysfunction in patients with liver cirrhosis without preexisting cardiac disease. According to the definition established by the World Congress of Gasteroenterology in 2005, the diagnosis of CCM includes criteria reflecting systolic dysfunction, impaired diastolic relaxation, and electrophysiological disturbances. Because of minimal or even absent clinical symptoms and echocardiographic signs at rest according to the 2005 criteria, CCM diagnosis is often missed or delayed in most clinically stable cirrhotic patients. However, cardiac dysfunction progresses in time and contributes to the pathogenesis of hepatorenal syndrome and increased morbidity and mortality after liver transplantation, surgery, or other invasive procedures in cirrhotic patients. Therefore, a comprehensive cardiovascular assessment using newer techniques for echocardiographic evaluation of systolic and diastolic function, allowing the diagnosis of CCM in the early stage of subclinical cardiovascular dysfunction, should be included in the screening process of liver transplant candidates and patients with cirrhosis in general. The present review aims to summarize the most important pathophysiological aspects of CCM, the usefulness of contemporary cardiovascular imaging techniques and parameters in the diagnosis of CCM, the current therapeutic options, and the importance of early diagnosis of cardiovascular impairment in cirrhotic patients.

show abstract

QT Indexes in Cirrhotic Patients: Relationship with Clinical Variables and Potential Diagnostic Predictive Value

Cited by 5 publications

References 37 publications

Association of Cirrhosis and Cardiomyopathy

Association of Cirrhosis and Cardiomyopathy

Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity

Cirrhotic Cardiomyopathy—A Veiled Threat

Contact Info

Product

Resources

About