QT Prolongation Due to Organophosphate Poisoning

Siu, Ayc; Цой, Л М; Lo, Wcb; Chung, Cch

doi:10.1177/102490790000700407

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Rehiman and colleagues 28 also found a significant correlation of serum cholinesterase levels with the severity and ultimate prognosis in OP poisoning. Siu 29 showed that severity of OP poisoning can be predicted by serum cholinesterase levels. However, Nouira and colleagues 30 found that mean cholinesterase levels did not correlate with respiratory failure.…”

Section: Resultsmentioning

confidence: 99%

Study of Glasgow Coma Scale Score and QTc Interval in Prognosis of Organophosphate Compound Poisoning

Deshpande

Gaikwad

Deshpande³

2012

Indian Journal of Clinical Medicine

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Abstract:We assessed the applicability of the Glasgow Coma Scale (GCS) and the QT interval (QTc) to predicting outcomes in patients with organophosphate (OP) poisoning. In the hospital setting, QTc and GCS were monitored in each patient at admission. Patients with respiratory failure were compared to patients without these complications, and mortality was compared between groups. We found that the group with complications had a significantly longer QTc and a lower GCS score, a higher number of intubations, and worse outcomes (P , 0.05). GCS score and QTc have been shown to be equally good in predicting respiratory failure and hospital mortality in patients with OP poisoning. These results suggest that during initial out-of-hospital care of patients with OP poisoning, it is essential to monitor the QTc and the GCS score. The simplicity and promptness of these methods will allow providers to perform early and effective triage.

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Section: Resultsmentioning

confidence: 99%

Study of Glasgow Coma Scale Score and QTc Interval in Prognosis of Organophosphate Compound Poisoning

Deshpande

Gaikwad

Deshpande³

2012

Indian Journal of Clinical Medicine

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“…From 73 patients who were referred to our center, 32 patients were excluded from the study due to their comorbid heart (10) and liver diseases (8), anemia (3), and poisoning with other toxins in addition to OPs pesticides (11). Of 41 patients, with mean age of 34.76±13 years (14-68 years), 19 were male and 22 were female.…”

Section: Resultsmentioning

confidence: 99%

“…4,5 It seems that careful ECG monitoring for detection of abnormal heart rhythms and subsequent implementation of an appropriate treatment modality to prevent from life-threatening arrhythmias can play a pivotal role in assessment and saving the lives of OPs poisoning patients. [9][10][11] Therefore, the present study was aimed to investigate the role of ECG monitoring combined with the introduction of anti-arrhythmic interventions on OPs poisoning outcomes including morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Association between ECG Alterations and Outcomes of Patients with Acute Organophosphate Poisoning

et al. 2020

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Background: Organophosphate (OP) poisoning leads to atrioventricular node blockade, alterations in ST segment, prolongation of QT interval, alterations in P wave, lethal arrhythmias, and cardiac arrest through the inhibition of acetylcholinesterase and consequent accumulation of free synaptic acetylcholine level. So the present study was aimed to investigate the role of electrocardiographic (ECG) monitoring combined with the introduction of anti-arrhythmic interventions on OPs poisoning outcomes. Methods: 41 patients with OPs poisoning were included. Patients with history of heart or liver diseases, cholinesterase deficiency, anemia, and poisoning with other toxins were excluded. Demographic characteristics, the time elapsed between OP ingestion and hospital admission, need for mechanical ventilation, and serum cholinesterase level were recorded. ECG of patients was analyzed for rate, rhythm, ST-T abnormalities, conduction defects, and measurement of PR and QT intervals. Study outcomes were measures of morbidity and mortality. Results: Of 41 patients, with mean age of 34.76±13 years, 19 were male. For 68.3% of the patients, the time elapsed between ingestion and hospital admission was 3-6 hours. Eight patients were treated with mechanical ventilation. There was a significant correlation between ST segment alterations and poisoning outcomes including uncomplicated discharge, complicated discharge, and death (P=0.02). Thirty one patients were discharged without any complication, 8 with morbidity and 2 expired. ST segment changes were seen in 4 patients. Two percent had PR interval greater than 0.21s and 3% had QT interval longer than 0.45s. The mean serum cholinesterase concentration was 3011.56 U/L. Conclusion: Due to lethal cardiac arrhythmia caused by OP poisoning, continuous monitoring, managing, and preventing irreparable effects of OP poisoning is highly emphasized.

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QT Prolongation Due to Organophosphate Poisoning

Cited by 2 publications

References 6 publications

Study of Glasgow Coma Scale Score and QTc Interval in Prognosis of Organophosphate Compound Poisoning

Study of Glasgow Coma Scale Score and QTc Interval in Prognosis of Organophosphate Compound Poisoning

Association between ECG Alterations and Outcomes of Patients with Acute Organophosphate Poisoning

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