Study of Glasgow Coma Scale Score and QTc Interval in Prognosis of Organophosphate Compound Poisoning

Deshpande, Archana; Gaikwad, Nitin; Deshpande, Sanjay

doi:10.4137/ijcm.s9807

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Identification of high death risk in OPP patients soon after presentation allows for more intensive monitoring and treatment. 17 Male participants were predominant in our study, as it can be assumed with the kind of poisoning we have as a subject and this is similar to what Lin TJ et al reported. 18 On the other hand, we found that the majority of the cases of poisoning were through oral intake, this mirrors the work of other authors.…”

Section: Discussionsupporting

confidence: 90%

Mortality among organophosphate poisoning patients presenting with low Glasgow coma scale score at A Tertiary Care Hospital.

Ali

Kumar

Ahmed

et al. 2020

TPMJ

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This study is designed to assess the mortality in OPP patients with low GCS scores. Study Design: Cross Sectional study. Setting: Jinnah Postgraduate Medical Center. Period: From 1st February 2018 to 31st August 2018. Material & Methods: Included patients with low GCS, both genders and age of 18-60 years diagnosed with OPP. Their GCS was calculated and the outcome was determined in terms of mortality. Results: Out of 70 patients, the mean age was 35.2+16.5 years with the majority (62.9%) <30 years. 62.9% of these were males. Most (57.1%) of them presented after ingestion of <15mL of OP, 60% had the poisoning for >60 minutes, and the majority (74.3%) had taken it orally. When the GCS was computed, 81.40% had that of >5, while the mean came out to be 6.64 ±1.43. The mortality rate here was 17.10%. Conclusion: GCS toll can be a helpful and practical tool in assessing the mortality among the patients of OPP. However, because of the limited literature on the subject further studies are recommended to improve its validity.

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Section: Discussionsupporting

confidence: 90%

Mortality among organophosphate poisoning patients presenting with low Glasgow coma scale score at A Tertiary Care Hospital.

Ali

Kumar

Ahmed

et al. 2020

TPMJ

View full text Add to dashboard Cite

show abstract

“…The Glasgow coma scale (GCS) remains the most widely used scale to describe the level of consciousness of the victim and is reliable for assessment and prognosis of patients with nontraumatic coma (Deshpande et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Triage Vital Signs and Conscious Level for Outcome Evaluation in Acutely Organophosphate Poisoned Patients

Moussa

Mohamed

Hilal

et al. 2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Triage in Emergency departments requires emergency doctors to make rapid decisions based on their knowledge and experiences. Triage of patients is critical to patient safety, yet no clear information exists by the utility of initial vital signs and conscious level in identifying critically ill acutely organophosphate (OP) poisoned patients. The objective of this study is to determine the relationship between triage vital signs and conscious level in predicting outcome of acutely organophosphate poisoned patients. A retrospective and prospective study was carried out on 200 patients of acute OP poisoning admitted to the Poison Control Center (PCC), Ain Shams University Hospitals. Information including vital signs and Glasgow coma scale (GCS) on admission after obtaining the permission of the director of PCC and the regional ethics committee was collected from the sheets and computerized data base of the patients, an informed written consent has been obtained from each patient or from his/her caregiver for inclusion in the prospective part of the study. The results were revised, coded and organized for statistical analysis. The study results revealed 180 (90%) patients discharged and 20 (10%) patients died. The study also showed that 8% of patients had fever, 9.5% had tachycardia, 1.5% had bradycardia, 5% had hypotension, 2% had hypertension, 2.5% had tachypnea and 3.5% showed bradypnea. Also 89% of patients had GCS > 8, while 11% of patients had GCS ≤ 8. The study showed statistically significant difference between discharged and died patients as regards heart rate, blood pressure, respiratory rate, body temperature and GCS. It could be concluded that heart rate, respiratory rate and coma scale can serve as easily measurable tools for outcome prediction in acutely OP poisoned patients. From the previous results, our study recommends to use these parameters to help emergency physicians to quickly detect poisoned patients with poor outcomes.

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The Accuracy Comparison of Scoring Systems in the Outcome Prediction of Acute Organophosphate Poisoning

Mohamed

Elnabi

Moussa

et al. 2019

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background: Organophosphates (OP) with high morbidity and mortality are one of the most common causes of poisoning especially in developing countries. Early diagnosis and appropriate treatment is often life saving as mortality rate of OP poisoning is still high. The objective of this study is to compare the accuracy of scoring systems (the sequential organ failure assessment (SOFA) score, acute physiology and chronic health evaluation II (APACHE II) score and glasgow coma scale (GCS)) in the prediction of mortality of acute organophosphate poisoning. Methodology: A retrospective and prospective study was done on 200 patients with acute OP poisoning admitted to the Poison Control Center (PCC), hospitals of Ain Shams University in the period between 1/1/2016 and 31/12/2016. Information was collected from the sheets and computerized data base of the patients. SOFA score, APACHE II score and GCS were calculated to each patient admitted. The results were revised, coded and organized for statistical analysis. Results: The study results revealed 180 (90%) patients recovered and 20 (10%) patients died. The area under the curve of receiver operator characteristic (ROC) of SOFA score was 0.995, for APACHE II score was 0.986 and compared to GCS was 0.977 with significantly higher SOFA and APACHE II scores in the died patients than in the recovered patients (P <0.001). As regards GCS there was statistically significant difference between recovered and died patients (P <0.001). Conclusion: It could be concluded that SOFA score, APACHE II score and GCS systems can be used to predict mortality of acute organophosphate poisoning with preference to SOFA score which had the highest accuracy and predictive ability. From the previous results, our study recommends that application of SOFA score, APACHEII score and GCS are good predictors of high mortality in OP intoxicated patients which helps in proper allocation of resources particularly for intensive care unit patients.

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Study of Glasgow Coma Scale Score and QTc Interval in Prognosis of Organophosphate Compound Poisoning

Cited by 4 publications

References 29 publications

Mortality among organophosphate poisoning patients presenting with low Glasgow coma scale score at A Tertiary Care Hospital.

Mortality among organophosphate poisoning patients presenting with low Glasgow coma scale score at A Tertiary Care Hospital.

Predictive Value of Triage Vital Signs and Conscious Level for Outcome Evaluation in Acutely Organophosphate Poisoned Patients

The Accuracy Comparison of Scoring Systems in the Outcome Prediction of Acute Organophosphate Poisoning

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