A time-dependent self-adjoint even Hamiltonian is defined by a linear combination of generators of the semidirect sum [Formula: see text], of the orthosymplectic plus the even Heisenberg algebra by computing the supercommutator of odd binary forms Π, given as linear combinations of odd bilinear generators of the odd Heisenberg algebra [Formula: see text] elements times [Formula: see text] elements, establishing a relationship between entangled boson systems and entangled fermion systems. This approach leads to the concept of intertwining, defined through the resulting quadratic Hamiltonians of bosons and, separately, of fermions with coefficients given in terms of the same coefficients of Π. Intertwining is invariant under transformations of Π, which leave certain binary forms of the coefficients of Π in the Hamiltonian unchanged. Alternatively, the coefficients can be interpreted as simultaneous time-dependent (super-) control parameters for both spin-statistics. Time-dependent inhomogeneous linear supercanonical transformations of wave vectors leave invariant the Heisenberg superalgebra [Formula: see text] and belong to the semidirect product Osp( m′/ n′) ⋉ N e( n′ + 1) of the orthosymplectic supergroup with the even Heisenberg group. The unitary time evolution operator is constructed using the adjoint map in canonical coordinates determined by the supercanonical transformation. The method is a generalization of an Inönu–Wigner contraction procedure and a Wei–Norman method for superalgebras with a selection of subalgebras associated with the root space decomposition of the Lie superalgebra. Analogously, this is a separation of variables method for quantum mechanical problems in systems with bosons and fermions. The standard Floquet theory leads to new results concerning stability for locally periodic coefficients. The lowest dimensional cases are explicitly computed. The intertwining of boson and fermions systems and the Hamiltonians considered here are of interest in quantum control theory for systems including fermions and bosons, in quantum optics, and quantum computation.