Quantum steering is the essential resource for quantum information processing. In this letter, a scheme is proposed to generate genuine quadripartite Einstein-Podolsky-Rosen (EPR) steering by an optical parametric oscillation cascaded with a sum-frequency process. Idler beam is generated by a difference frequency generation process between pump and injected signal in an optical superlattice. Then, a sum-frequency beam is produced by the cascaded sum-frequency process between pump and idler beams in the same optical superlattice by the quasi-phase-matching technique. The genuine quadripartite EPR steering among pump, signal, idler, and sum-frequency beams is confirmed in this scheme by applying a criteria for genuine multipartite EPR steering. The variation properties of the EPR steering with pump and nonlinear coupling coefficients are also discussed.