Qualitative and quantitative measurements of oligonucleotides in gene therapy: Part II in vivo models

Tewary, Hemant K.; Iversen, Patrick L.

doi:10.1016/s0731-7085(97)01942-0

Cited by 7 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although they have been "shunned" by the pharmaceutical community in the past due to lack of knowledge, they have recently found many applications and are considered to be the most important tools to many areas of research (120). They have been used for gene therapy (121), as antisense agents to treat diseases like leukemia (122), as molecular probes (123), etc. Adding different functional groups further increases their versatility, especially when one considers that functionalization can be introduced at either the 3′-end, 5′-end, or an internal position.…”

Section: Labeling Dnamentioning

confidence: 99%

Click Chemistry, A Powerful Tool for Pharmaceutical Sciences

2008

View full text Add to dashboard Cite

Abstract. Click chemistry refers to a group of reactions that are fast, simple to use, easy to purify, versatile, regiospecific, and give high product yields. While there are a number of reactions that fulfill the criteria, the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes has emerged as the frontrunner. It has found applications in a wide variety of research areas, including materials sciences, polymer chemistry, and pharmaceutical sciences. In this manuscript, important aspects of the Huisgen cycloaddition will be reviewed, along with some of its many pharmaceutical applications. Bioconjugation, nanoparticle surface modification, and pharmaceutical-related polymer chemistry will all be covered. Limitations of the reaction will also be discussed.

show abstract

Section: Labeling Dnamentioning

confidence: 99%

Click Chemistry, A Powerful Tool for Pharmaceutical Sciences

2008

View full text Add to dashboard Cite

show abstract

“…Quantitative and qualitative measurements of PS-ODN were done using previously published methods. 8 Atomic Absorption Spectroscopy. Urine samples from patients were diluted in 1.0 % nitric acid at both 1 : lyzed using flame atomic absorption.…”

Section: Methodsmentioning

confidence: 99%

Evidence of Enhanced Iron Excretion During Systemic Phosphorothioate Oligodeoxynucleotide Treatment

Mata

Bishop

Tarantolo

et al. 2000

Journal of Toxicology: Clinical Toxicology

View full text Add to dashboard Cite

show abstract

“…One of the simplest forms of DNA is oligonucleotide. Synthetic oligonucleotides are widely used as an essential component of PCR (Dieffenbach et al, 1993;Halford, 1999), probes for various detection schemes (Mitsuhashi et al, 1994), even therapeutic agents as anti-sense drug (Pirollo et al, 2003;Tewary and Iversen, 1997) and agents for RNA interference (Doran, 2004). Some of these applications demand accurate quantitation of oligonucleotides.…”

Section: Backgroundsmentioning

confidence: 99%