Qualitative and semi-quantitative screening of selected psychoactive drugs in blood: Usefulness of liquid chromatography – triple quadrupole and quadrupole time-of-flight mass spectrometry in routine toxicological analyses

Degreef, Maarten; Berry, Eleanor M.; Maudens, Kristof E.; Nuijs, Alexander L.N. van

doi:10.1016/j.jchromb.2022.123279

Cited by 2 publications

(1 citation statement)

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“…Many analytical techniques have been reported in the literature for the assay of BRZ either alone or in conjunction with other drugs in dosage form and/or body fluids. These techniques include ultraviolet (UV)–visible spectroscopy [ 8 , 9 , 10 , 11 , 12 ], fluorimetry [ 8 , 13 ], liquid chromatography (LC) [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], gas chromatography connected to mass spectrometry (GS/MS) [ 27 , 28 , 29 ], and capillary electrophoresis (CE) [ 30 , 31 ]. Potentiometric membrane sensors, either inner liquid [ 32 , 33 , 34 ] or solid-contact electrodes [ 35 ], were used for the determination of BRZ in its tablet form, biological fluids, and wastewater effluents.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study between Screen-Printed and Solid-Contact Electrodes for the Stability-Indicating Determination of Bromazepam

Abdel-Gawad

Altharawi

2022

Molecules

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Stability-indicating methods are awesome tools to ensure the safety and efficacy of active pharmaceutical ingredients (APIs). An accurate comparative study involving the use of potentiometric sensors for the determination of bromazepam (BRZ) in the presence of its main product of degradation and impurity was performed by the fabrication of two membrane electrodes. A screen-printed electrode (SPE) and a solid-contact glassy carbon electrode (SCE) were fabricated and their performance optimized. The fabricated sensors showed a linear electrochemical response in the concentration range 1.0 × 10−6 M to 1.0 × 10−2 M. The electrodes exhibited Nernstian slopes of 59.70 mV/decade and 58.10 mV/decade for the BRZ-SPE and BRZ-SCE membrane electrodes, respectively. The electrochemical performance was greatly affected by the medium pH. They showed an almost ideal electrochemical performance between pH 3.0 and pH 6.0. The fabricated membranes were applied successfully for the quantification of BRZ in the presence of up to 90% of its degradation product. Moreover, a successful application of the fabricated electrodes was performed for the sensitive and selective quantification of BRZ in its tablet form without any pretreatment procedure.

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