Qualitative Assessment of Adult Patients’ Perception of Atopic Dermatitis Using Natural Language Processing Analysis in a Cross-Sectional Study

Falissard, Bruno; Simpson, Eric L.; Guttman‐Yassky, Emma; Papp, Kim; Barbarot, S.; Gadkari, Abhijit; Saba, G.; Gautier, Laurene; Abbé, Adeline; Eckert, Laurent

doi:10.1007/s13555-020-00356-0

Cited by 21 publications

(17 citation statements)

References 22 publications

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“…Furthermore, the current data confirm that the severity of the dermatological disease as perceived by patients can exacerbate depressive symptoms due to the stigma deriving from the dermatological lesions and the consequent anxiety (35). Anxiety, in turn, as confirmed by the current results, is an important factor associated with depressive symptoms, reproducing the vicious circle that links affective symptoms, perceived dermatological severity and poor QoL (36).…”

Section: Discussionsupporting

confidence: 78%

Factors Associated with Affective Symptoms and Quality of Life in Patients with Atopic Dermatitis

Ferrucci¹,

Tavecchio²,

Angileri³

et al. 2021

Acta Derm Venereol

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The aim of this study was to detect demographic and clinical factors associated with affective symptoms and quality of life in patients with severe atopic dermatitis. First, one-way analyses of variance and correlations were performed to compare a large set of qualitative and quantitative clinical variables. Three final multivariable regression models were performed, with depression/anxiety subscales and Dermatology Life Quality Index scores as dependent variables, and the factors that were statistically significant on univariate analyses as independent ones. More severe anxiety symptoms and poorer quality of life (p < 0.01) were significantly associated with more severe depressive symptoms. Female sex and disturbed sleep (p = 0.03) were significantly associated with more severe anxiety. Finally, previous treatment with cyclosporine (p = 0.03) or methotrexate (p = 0.04), more severe depressive symptoms (p < 0.01), itch (p = 0.03), impaired sleep (p < 0.01) and perceived severity of dermatological illness (p < 0.01) were significant predictors of low quality of life. This study shows a complex interplay between the severity of atopic dermatitis, poor quality of life and presence of clinically relevant affective symptoms. These results will help dermatologists to identify patients who need psychiatric consultation within the framework of a multidisciplinary approach.

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Section: Discussionsupporting

confidence: 78%

Factors Associated with Affective Symptoms and Quality of Life in Patients with Atopic Dermatitis

Ferrucci¹,

Tavecchio²,

Angileri³

et al. 2021

Acta Derm Venereol

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“…Itching was the most commonly mentioned clinical impact due to AD. Based on the aggregated data points, the itching or pruritis prevalence in patients with AD ranged from 21% up to 100% [30][31][32][33][34][35].…”

Section: Clinical Burdenmentioning

confidence: 99%

Burden of Atopic Dermatitis in Adults and Adolescents: a Systematic Literature Review

Fasseeh

Elezbawy²,

Korra³

et al. 2022

Dermatol Ther (Heidelb)

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Introduction: Although previously regarded as a children's disease, it is clear that atopic dermatitis (AD) is also highly prevalent in adults. Because AD is not associated with mortality, it is usually neglected compared with other, fatal diseases. However, several studies have highlighted that AD burden is significant due to its substantial humanistic burden and psychosocial effects. This study aims to summarize and quantify the clinical, economic, and humanistic burden of AD in adults and adolescents. Methods: A systematic literature search was performed in PubMed, Scopus, Cochrane, Centre for Reviews and Dissemination (CRD),

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“…Atopic eczema (AE) is a chronic inflammatory disease which may be associated with several atopic and nonatopic comorbidities [1][2][3]. Increased numbers of patients with AE were reported to suffer from depression (9.3-44.3%) and/or anxiety (3.31-26.2%) [2,[4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Depression, Anxiety, and Suicidal Ideation in Patients with Atopic Eczema in a Prospective Study in Leipzig, Germany

Kage¹,

Poblotzki²,

Zeynalova

et al. 2021

Int Arch Allergy Immunol

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Background: Atopic eczema (AE) is known to be associated with depression and anxiety. We aimed at investigating the occurrence of selected psychological comorbidities in patients with AE under treatment in our university dermatological department. Methods: Monocentric prospective examination of adult AE patients using PO-SCORAD (Patient-Oriented Severity Scoring of AD), EASI (Eczema Area and Severity Index), POEM (Patient-Oriented Eczema Measure), DLQI (Dermatologic Life Quality Index), LSNS-6 (Lubben Social Network Scale 6), CES-D (Center for Epidemiologic Studies Depression Scale), HADS-D and -A (Hospital Anxiety and Depression Scale), and GAD-7 (Generalized Anxiety Disorder Scale-7) was carried out. We looked for correlations between AE severity and psychosocial comorbidities. Data were compared with age- and sex-matched controls from nonatopic subjects. Statistics: Mann-Whitney U test and Spearman’s rank correlation were used. Results: Eighty-four patients (44 women, median age 35.0 years, range: 19.4–92.8 years) were included. PO-SCORAD was 40.4 [23.4–55.4] (median [interquartile range]), EASI 9.3 [3.4–18.9], POEM 16 [8–24], and DLQI 10 [4–18]. Compared with 161 from the healthy LIFE-Adult cohort controls, our patients with AE had significantly higher scores for HADS, GAD-7, and CES-D (p < 0.001, respectively), but there was no increase in the LSNS score (18 vs. 19; p = 0.067). Within the group of AE patients, there was a significant correlation of the subjective skin severity and the depression and anxiety values: POEM significantly correlated with GAD-7, CES-D, and HADS-A and -D (p < 0.001). PO-SCORAD significantly correlated with GAD-7 and CES-D (p < 0.05). EASI correlated neither with HADS-A or -D nor with CES-D. Patients with suicidal thoughts, plans, or attempts in the last 12 months had significantly more severe AE than those without (POEM 25 [15.3–26] vs. 15 [7–23]; p = 0.013, and PO-SCORAD 51.6 [40.2–63] vs. 20.5 [20.7–52]; p = 0.014). Conclusion: Patients with AE being currently under treatment in our department had significantly increased scores indicating depression and anxiety. Suicidal tendency was increased in patients with severe AE. Key Message: AE patients may develop depression, anxiety, and suicidal ideation. Patient-oriented scores may help identifying high-risk patients.

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Qualitative Assessment of Adult Patients’ Perception of Atopic Dermatitis Using Natural Language Processing Analysis in a Cross-Sectional Study

Cited by 21 publications

References 22 publications

Factors Associated with Affective Symptoms and Quality of Life in Patients with Atopic Dermatitis

Factors Associated with Affective Symptoms and Quality of Life in Patients with Atopic Dermatitis

Burden of Atopic Dermatitis in Adults and Adolescents: a Systematic Literature Review

Depression, Anxiety, and Suicidal Ideation in Patients with Atopic Eczema in a Prospective Study in Leipzig, Germany

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