In this article, we are interested in studying the asymptotic behavior of fourth-order neutral differential equations. Despite the growing interest in studying the oscillatory behavior of delay differential equations of second-order, fourth-order equations have received less attention. We get more than one criterion to check the oscillation by the generalized Riccati method and the integral average technique. Our results are an extension and complement to some results published in the literature. Examples are given to prove the significance of new theorems.