1997
DOI: 10.1017/s0033291796004576
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Qualitative magnetic resonance imaging findings in geriatric depression. Possible link between later-onset depression and Alzheimer's disease?

Abstract: Results indicate non-specificity and lack of homogeneity of qualitatively measured structural brain changes in geriatric depression, but suggest that pathology of specific, lateralized brain regions may be implicated in some later-onset patients. The relationship between medial temporal atrophy and late-onset depression raises the possibility that such patients may suffer from as-yet undeclared Alzheimer's disease. Lack of association between cerebrovascular disease risk factors and brain changes suggests othe… Show more

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Cited by 88 publications
(70 citation statements)
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“…According to the prodromal dementia hypothesis of LLD, a subgroup of subjects develops LLD as a very early clinical presentation of dementia (Alexopoulos et al, 1993;O'Brien et al, 2004;Steffens et al, 2000). In this case, lower volumes would be interpreted as a marker of neuronal loss related to an as yet undeclared neurodegenerative or vascular process (Alexopoulos et al, 1993; Greenwald et al, 1997). Most findings supporting this theory have been described in left medial temporal lobe (Greenwald et al, 1997), left caudate (Greenwald et al, 1997; Krishnan et al, 1992), anterior cingulate (Drevets et al, 1997), and putamen (Husain et al, 1991).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…According to the prodromal dementia hypothesis of LLD, a subgroup of subjects develops LLD as a very early clinical presentation of dementia (Alexopoulos et al, 1993;O'Brien et al, 2004;Steffens et al, 2000). In this case, lower volumes would be interpreted as a marker of neuronal loss related to an as yet undeclared neurodegenerative or vascular process (Alexopoulos et al, 1993; Greenwald et al, 1997). Most findings supporting this theory have been described in left medial temporal lobe (Greenwald et al, 1997), left caudate (Greenwald et al, 1997; Krishnan et al, 1992), anterior cingulate (Drevets et al, 1997), and putamen (Husain et al, 1991).…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have reported smaller left medial temporal and left caudate volumes (Greenwald et al, 1997), and right hemisphere frontal atrophy more prominent in late-onset depression, when compared with early-onset depression (Almeida et al, 2003). White matter lesions in the medial orbital region also correlate with depression severity (MacFall et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…Several distinctions between these groups have been identified, and subjects with early-onset depression are more likely to have a family history of psychiatric illness (Brodaty et al, 2001), while subjects with late-onset depression have greater subcortical ischemic disease (Krishnan et al, 1988;Salloway et al, 1996;Taylor et al, 2004). In addition, late-onset depression has been associated with more pronounced temporal lobe atrophy (Greenwald et al, 1997;Kumar et al, 1998) and hippocampal volume reductions (Steffens et al, 2000;Hickie et al, 2005), with specific genotypes possibly mediating this effect (Taylor et al, 2005). If these previous investigations are interpreted to be signs of different causes or risk factors for depression based on age at onset, greater splenium thinning in late-than early-onset depression might indeed point to more prominent atrophic or neurodegenerative processes in temporal connections, possibly reflecting higher risk for cognitive impairment and dementia conversion in the future (Geda et al, 2006;Salloway et al, 1996;Schweitzer et al, 2002;van Ojen et al, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…[35] The cortico-limbic circuit is currently gaining attention due to its ability of mediating stress response and playing an important role in the regulation of emotions. In early neuroimaging studies, which investigated the role of the limbic area in depression, the structural abnormalities of the limbic area, such as the atrophy or bilateral loss of the amygdala [36,37] and the volume reduction of the hippocampus [38,39] and caudate nucleus [40], were consistently reported in depressive patients. In addition, functional neuroimaging studies reported that the increased activation of the amygdala [41] and the reduced connectivity of the amygdalacingulate [42] were observed when the subjects were exposed to negative stimulation such as a scary facial expression.…”
Section: Neuroimaging Study On Depressive Disordermentioning
confidence: 99%