Qualitative variation of anti-diabetic compounds in different tarragon (Artemisia dracunculus L.) cytotypes

Eisenman, Sasha W.; Poulev, Alexander; Struwe, Lena; Raskin, Ilya; Ribnicky, David M.

doi:10.1016/j.fitote.2011.07.003

Cited by 39 publications

(35 citation statements)

References 47 publications

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“…Artemisia dracunculus has been widely used in traditional medicine, and a large number of researchers confirm this species' has a beneficial pharmacological activity like hepatoprotective effect, antiinflammatory activity, anti-hyperglycemic action, anti-hyperlipidemia action, antibacterial, antifungal, antioxidant activity, neurotrophic activity, anticancer activity and in the treatment of sickle cell anemia [26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

EXTRACTION AND CHARACTERIZATION OF IRAQI ARTEMISIA DRACUNCULUS DRIED AERIAL PARTS EXTRACT THOUGH HPLC AND GC-MS ANALYSIS WITH EVALUATION OF ITS ANTITUMOR ACTIVITY AGAINST 7, 12-DIMETHYLBENZE (a) ANTHRACENE INDUCED SKIN CANCER IN MICE

Ibrahem

2017

Int J Pharm Pharm Sci

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Objective: This study focused on the extraction of bioactive constituents in Iraqi cultivated Artemisia dracunculus L dried aerial parts and phytochemical screening with qualitative estimation of three important flavonols (kampferol, quercetin and rutin). The study also included evaluating the antitumor effects (skin cancer) of methanolic extract for this plant.Methods: Extraction of bioactive constituents was carried out according to standard protocols using 85% methanol. The phytochemical screening has been done using chemical tests and GC/MS with qualitative estimation of three flavonols (kampferol, quercetin and rutin) utilized preparative high-performance liquid chromatography (PHPLC). Skin cancer in mice was induced by using 7, 12-dimethylbenze (a) anthracene to evaluate the antitumor effect of methanolic extract of Artemisia dracunculus when administered orally via intragastric feeding tube. Body weight, tumor volume, tumor burden, percent of tumor incidence and histopathological examination were measured in all tested animals.Results: Phytochemical screening revealed the presence of glycosides, volatile oils, alkaloids, tannin, terpenoids, phenolic compounds and flavonoids. The preparative high-performance liquid chromatography (PHPLC) analysis indicated that rutin had the highest concentration followed by quercetin while kampferol had the lowest concentration. The methanolic extract of the Artemisia dracunculus significantly reduced the percent of tumor incidence, tumor volume and tumor burden of skin cancer in mice (p<0.05). Conclusion:Dried aerial parts of Iraqi Artemisia dracunculus contain many bioactive constituents including three flavonoid compounds (quercetin, kampferol and rutin) that may be responsible for chemo preventive effect exerting by methanolic extract of Artemisia dracunculus against 7, 12-dimethylbenzeanthracine-induced skin cancer in mice.

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Section: Discussionmentioning

confidence: 99%

EXTRACTION AND CHARACTERIZATION OF IRAQI ARTEMISIA DRACUNCULUS DRIED AERIAL PARTS EXTRACT THOUGH HPLC AND GC-MS ANALYSIS WITH EVALUATION OF ITS ANTITUMOR ACTIVITY AGAINST 7, 12-DIMETHYLBENZE (a) ANTHRACENE INDUCED SKIN CANCER IN MICE

Ibrahem

2017

Int J Pharm Pharm Sci

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“…They are found in a variety of plant species as well as throughout the human diet in foods such as fruits and vegetables, tea, and cocoa and have been described for their various health benefits [44]. Sakuranetin is the major flavonoid found in rice [45] and it has been primarily studied for its anti-inflammatory [46], anti-diabetic [47], and anti-bacterial [48] properties. Rhamnetin is found in most buckthorns (rhamnus genus) [49] and has been primarily studied for its anti-cancer [50], antioxidant [51] and anti-inflammatory properties [41].…”

Section: Discussionmentioning

confidence: 99%

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia

et al. 2014

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The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAChR. Flavonoids are not known for this activity, so we screened a small library of pure flavonoids to confirm our findings. Some flavonoids, e.g. rhamnetin, displaced a selective alpha7 nAChR radioligand from rat brain membranes whereas similar structures e.g. sakuranetin, did not. To evaluate the contribution of this putative nAChR activity to the known anti-inflammatory properties of these flavonoids, we compared their effects on lipopolysaccharide induced release of inflammatory mediators from BV2 microglia. Both rhamnetin and sakuranetin reduced mediator release, but differed in potency (rhamnetin>sakuranetin) and the Hill slope of their concentration response curves. For rhamnetin the Hill coefficient was >3.0 whereas for sakuranetin the coefficient was 1.0, suggesting that effects of rhamnetin are mediated through more than one mechanism, whereas sakuranetin has a single mechanism. nACHR antagonists decreased the Hill coefficient for rhamnetin toward unity, which suggests that a nAChR-mediated mechanism contributes cooperatively to its overall anti-inflammatory effect. In contrast nAChR antagonists had no effect on the potency or Hill coefficient for sakuranetin, but a concentration of nicotine (1μM) that had no effect alone, significantly increased the Hill coefficient of this flavonoid. In conclusion, the anti-inflammatory effects of rhamnetin benefit cooperatively from a nAChR-mediated mechanism. This action, together with potent free radical scavenging activity, suggests that flavonoids with alpha7 nAChR activity have therapeutic potential in neuroinflammatory conditions.

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“…Logendra et al (2006) isolated 4,5-di-O-caffeoylquinic acid, 6-demethoxycapillarisin, and 2' ,4'-dihydroxy-4-methoxydihydrochalcone from the ethanolic extract of Artemisia dracunculus L. The compounds showed inhibitory effects towards the enzyme aldose reductase, a key enzyme involved in diabetic complications, which may explain the antidiabetic effect. The bioactive compounds in Artemisia dracunculus L. also include davidigenin, sakuranetin, and 5-O-caffeoylquinic acid (Eisenman et al, 2011).…”

Section: A Plant Extracts With Antidiabetic Actionmentioning

confidence: 99%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

132

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Diabetes has become the most common metabolic disease worldwide. In particular, type 2 diabetes is the most commonly encountered type of diabetes, which is characterised by the inability of the organism to respond to normal levels of circulating insulin, also called insulin resistance. Current antidiabetic therapy is based on synthetic drugs that very often have side effects. For this reason, there is a continuous need to develop new and better pharmaceuticals as alternatives for the management and treatment of the disease. Natural hypoglycaemic compounds may be attractive alternatives to synthetic drugs or reinforcements to currently used treatments. Their huge advantage is that they can be ingested in everyday diet. Recently, more attention is being paid to the study of natural products as potential antidiabetics. This mini review of the current literature is structured into three main sections focused on: (a) plant extracts, (b) plant biomolecules, and (c) other natural molecules that have been used for their antidiabetic effects. Potential molecular mechanisms of action are also discussed.

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Qualitative variation of anti-diabetic compounds in different tarragon (Artemisia dracunculus L.) cytotypes

Cited by 39 publications

References 47 publications

EXTRACTION AND CHARACTERIZATION OF IRAQI ARTEMISIA DRACUNCULUS DRIED AERIAL PARTS EXTRACT THOUGH HPLC AND GC-MS ANALYSIS WITH EVALUATION OF ITS ANTITUMOR ACTIVITY AGAINST 7, 12-DIMETHYLBENZE (a) ANTHRACENE INDUCED SKIN CANCER IN MICE

EXTRACTION AND CHARACTERIZATION OF IRAQI ARTEMISIA DRACUNCULUS DRIED AERIAL PARTS EXTRACT THOUGH HPLC AND GC-MS ANALYSIS WITH EVALUATION OF ITS ANTITUMOR ACTIVITY AGAINST 7, 12-DIMETHYLBENZE (a) ANTHRACENE INDUCED SKIN CANCER IN MICE

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia

Plants and Natural Compounds with Antidiabetic Action

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