Quality assessment and antiplasmodial activity of West African Cochlospermum species

Lamien-Meda, Aline; Kiendrebéogo, Martin; Compaoré, Moussa; Meda, Roland Nâg-Tiéro; Bacher, Markus; Koenig, K.; Pacher, Thomas; Fuehrer, Hans‐Peter; Noedl, Harald; Willcox, Merlin; Novak, Johannes

doi:10.1016/j.phytochem.2015.09.006

Cited by 16 publications

(12 citation statements)

References 39 publications

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“…Other Cochlospermum species, mostly C. tinctorium , have also been investigated. For example, extracts of the root and rhizome of C. tinctorium have been evaluated for cytotoxic, antimicrobial, antiplasmodial, anti-ulcer, antioxidant, hepatoprotective, and immunomodulating effects [8,9,10,11,12]. Preliminary antibacterial and antifungal evaluation was also performed on the ethanolic leaf extract of Brazilian C. regium [13].…”

Section: Introductionmentioning

confidence: 99%

Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv

Abourashed

2017

Antioxidants

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Borututu (Cochlospermum angolensis) is an African tree whose bark has recently emerged as a herbal dietary supplement with claims for antioxidant activity. In order to substantiate the claimed activity of borututu supplements, we performed an activity-guided fractionation of the total extract utilizing a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Subsequent flash and centrifugal chromatography resulted in the isolation of gallic acid (1) and protocatechuic acid (2) as the main antioxidant constituents. Two apocarotenoids and one flavonoid were also isolated from the chloroform fraction and were identified as cochloxanthin (3), dihydrocochloxanthin (4), and 7,4′-dimethyltaxifolin (5), respectively. A High-performance liquid chromatography (HPLC) method was also developed for fingerprinting borututu samples, with Compounds 1–4 suggested as chemical markers for quality control purposes.

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Section: Introductionmentioning

confidence: 99%

Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv

Abourashed

2017

Antioxidants

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“…They include β-carotene, albumin, uric acid, oestrogens, polyamines, flavonoids, ascorbic acid, vitamin E, phenolic compounds, the flavonoïds, zinc and selenium [6]. In this study we studied the correlation between the flavonoïds, total polyphenols and zinc content and the antiradical capacity of three extracts of plant used in traditional medicine to treat malaria [35,36]. Therefore, it was observed a strong correlation between the antiradical activity and the simultaneous presence of the three compounds which are the polyphenols, total flavonoïds and zinc.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant Activities and Estimation of Zinc Content of Aqueous and Methanolic Extracts of Three Medicinal Plants: Cochlospermum Planchonii, Pericopsis Laxiflora and Harungana Madagascariensis

Jeanne¹,

Brice²,

Dieudonné³

et al. 2016

ijbb

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Malaria disease is a pathology which occurs as a result of the oxidative stress. Three plants of the Ivorian pharmacopoeia are particularly used in the traditional medicine for the treatment of malaria in Côte d'Ivoire. They are Cochlospermum planchonii (Placo), Pericopsis laxiflora (Laper) and Harungana madagascariensis (Madhar).The objective of this study was to evaluate the in vitro antioxidant activity of the aqueous and methanolic extracts of three medicinal plants of Côte d'Ivoire. The quantitative measurement of total flavonoids gave the following results: Laper (560.80 mg QE/g ± 7.40), Madhar (352.50 mg QE/g ± 9.46) and Placo (314.20 mg QE/g ± 4.41). The total polyphenols were more concentrated in Laper (262.50 mg GAE/g ± 9.47) and Placo (203.20 mg GAE/g ± 2.21). Noticeable zinc content was found in Laper (13.56 ppm) and Placo (11.40 ppm) against 3.43 ppm in Madhar. The radical scavenging activity by 2,2-diphenyl-1-picryl hydrazyl (DPPH) and antiradical power measurement by ABTS (2,2' azino bis-3-ethylbenzothiazoline-6-sulphonic acid) assay have showed good activity for Laper (IC 50 = 7.50 µg/mL) and placo (IC 50 = 8.01 µg/mL). The standard antioxidant compound (quercetin) gave an IC 50 = 4.00 µg/mL. This study suggested that the high content of total flavonoids, total phenols and minerals in these plants could partly justify the therapeutic use of at least two of the three plants.

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“…Indeed, not only the Cinchona tree but other plants species have also been found to have pharmacological properties against the malaria parasite ( Table 1 ). This is the case of an herbal remedy based on three plants: Cochlospermum planchonii , Phyllanthus amarus , and Cassia alata ( Kaushik et al, 2015 ; Lamien-Meda et al, 2015 ). C. planchonii roots alleviate malarial symptoms, while P. amarus and C. alata leaves and aerial tissues have anti-malarial activity.…”

Section: Malaria Prevention and Treatment Using Plant-based Medicinesmentioning

confidence: 99%

“…C. planchonii roots alleviate malarial symptoms, while P. amarus and C. alata leaves and aerial tissues have anti-malarial activity. Moreover, the active compounds of these three plant species are able to act synergistically as a proper anti-malarial phyto-medicine ( Kaushik et al, 2015 ; Lamien-Meda et al, 2015 ). Similar results have been found within the diverse range of indigenous Amazonian plants so far studied: Aspidosperma rigidum , Ampelozizyphus amazonicus, Bertholletia excels , and Simaba cedron have all been found to contain the most active anti-malarial extracts among the amazon plants tested to date ( Frausin et al, 2015 ; Oliveira et al, 2015 ) ( Table 1 ).…”

Section: Malaria Prevention and Treatment Using Plant-based Medicinesmentioning

confidence: 99%

Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production

Pulice¹,

Pelaz

Matías‐Hernández

2016

Front. Plant Sci.

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Malaria is a parasite infection affecting millions of people worldwide. Even though progress has been made in prevention and treatment of the disease; an estimated 214 million cases of malaria occurred in 2015, resulting in 438,000 estimated deaths; most of them occurring in Africa among children under the age of five. This article aims to review the epidemiology, future risk factors and current treatments of malaria, with particular focus on the promising potential of molecular farming that uses metabolic engineering in plants as an effective anti-malarial solution. Malaria represents an example of how a health problem may, on one hand, influence the proper development of a country, due to its burden of the disease. On the other hand, it constitutes an opportunity for lucrative business of diverse stakeholders. In contrast, plant biofarming is proposed here as a sustainable, promising, alternative for the production, not only of natural herbal repellents for malaria prevention but also for the production of sustainable anti-malarial drugs, like artemisinin (AN), used for primary parasite infection treatments. AN, a sesquiterpene lactone, is a natural anti-malarial compound that can be found in Artemisia annua. However, the low concentration of AN in the plant makes this molecule relatively expensive and difficult to produce in order to meet the current worldwide demand of Artemisinin Combination Therapies (ACTs), especially for economically disadvantaged people in developing countries. The biosynthetic pathway of AN, a process that takes place only in glandular secretory trichomes of A. annua, is relatively well elucidated. Significant efforts have been made using plant genetic engineering to increase production of this compound. These include diverse genetic manipulation approaches, such as studies on diverse transcription factors which have been shown to regulate the AN genetic pathway and other biological processes. Results look promising; however, further efforts should be addressed toward optimization of the most cost-effective biofarming approaches for synthesis and production of medicines against the malaria parasite.

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Quality assessment and antiplasmodial activity of West African Cochlospermum species

Cited by 16 publications

References 39 publications

Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv

Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv

Evaluation of Antioxidant Activities and Estimation of Zinc Content of Aqueous and Methanolic Extracts of Three Medicinal Plants: Cochlospermum Planchonii, Pericopsis Laxiflora and Harungana Madagascariensis

Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production

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