Quality assurance in breast cancer brachytherapy: Geographic miss in the interstitial boost treatment of the tumor bed

5-Year Results of Pulsed Dose Rate Brachytherapy Applied as a Boost after Breast-Conserving Therapy in Patients at High Risk for Local Recurrence from Breast Cancer

“…Several studies have previously shown that traditional clinical parameters used for definition of the boost volume can lead to a geographical miss in up to 78.5% [19,46]. As a consequence, a precise determination of the planning target volume (PTV) preferentially using clips has been suggested by the GEC-ESTRO consensus meeting on breast cancer [20].…”

Comparison of Photon with Electron Boost in Treatment of Early Stage Breast Cancer

“…Studies have shown that planning target definition for boost irradiation without the use of surgical clips and/or CT were inadequate in 70-80% [7][8][9][10][11][12].…”

Local Recurrence Rates in Breast Cancer Patients Treated with Intraoperative Electron-Boost Radiotherapy Versus Postoperative External-Beam Electron-Boost Irradiation

“…Several methods are used to exactly localize the tumor bed: tumor bed clipping by the surgeon with titanium clips, perioperative brachytherapy, or intraoperative radiotherapy (IORT). A partial topographic miss of the target could be a reason for local recurrence after boost therapy [29]. Linacbased IORT with high-energy electrons for breast cancer was initially introduced by Dubois et al, Merrick et al and Dobelbower et al [10,11,20], though this technique originated at the University of Kyoto in Japan by Abe et al [1][2][3][4].…”