Quality Characteristics and Biological Activities of Vinegars Added with Young Leaves of Akebia quinata

Kwon, Woo-Young; Lee, Eun‐Kyoung; Yoon, Jina; Chung, Kang-Hyun; Lee, Kwon-Jai; Song, Byeong Chun; An, Jeung Hee

doi:10.3746/jkfn.2014.43.7.989

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…This decrease in pH is attributed to acetic acid bacteria utilizing alcohol as an energy source and fermentation substrate to produce acetic acid ( Bang et al, 2020 ). The total acidity serves as a vinegar quality indicator as acetic acid bacteria can break down alcohol to produce acetic acid and CO 2 ( Kwon et al, 2014 ; Park et al, 2021 ). The total acidity contents of vinegars are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Fermentation Characteristics of Unripe Citrus unshiu Vinegar Production Using Acetic Acid Bacteria Isolated from Traditional Fermented Vinegars

Won,

Kim,

Choi

et al. 2024

Prev. Nutr. Food Sci.

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Section: Resultsmentioning

confidence: 99%

Fermentation Characteristics of Unripe Citrus unshiu Vinegar Production Using Acetic Acid Bacteria Isolated from Traditional Fermented Vinegars

Won,

Kim,

Choi

et al. 2024

Prev. Nutr. Food Sci.

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“…Currently, most of the research on A. quinata has focused on the biological and phytochemical characteristics of the stems and fruits rather than the leaves [ 14 , 15 , 16 ]. Interestingly, A. quinata leaves are registered as a food in the Korean food safety database, indicating that the leaves could be used as a raw material for developing functional foods [ 17 , 18 ]. Among the public, A. quinata leaves are blanched and used as a food to treat obesity and cardiovascular disease [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Profile and Fingerprint Analysis of Akebia quinata Leaves Extract with Endothelial Protective Activity

Cho

Kim

et al. 2022

Molecules

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In contrast to the stem and fruit of Akebia quinata, A. quinata leaves as a source rich in phenolic compounds with potentially beneficial pharmacological activities have been largely overlooked. To develop and use A. quinata leaves as a resource, we evaluated its potential as a cardiovascular-protective agent. Herein, we investigated the effects and potential mechanisms of A. quinata leaves extract on lipopolysaccharide (LPS)-induced inflammatory responses in human umbilical vein endothelial cells. We found that A. quinata leaves extract pretreatment of 10 μg/mL significantly attenuated LPS-induced protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1. Furthermore, this extract also suppressed LPS-induced phosphorylation of nuclear factor-κB p65. In order to elucidate the chemical profiles of the samples, the HPLC fingerprint was established, and prominent peaks were identified via HPLC–electrospray ionization–mass spectrometry. Multivariate statistical analyses, including hierarchical cluster analysis, principal component analysis, and partial least-squares discriminant analysis, were performed to evaluate the clustering of the samples. It was found that isochlorogenic acid C was a key marker for the classification of A. quinata leaves from the Gongju and Muju city in Korea. Collectively, this study not only suggested the potential of A. quinata leaves as a novel therapeutic candidate for inflammatory cardiovascular disease but also developed a quality control method for A. quinata leaves, which could help to expand the application of A. quinata.

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“…There is limited research being done so far on the combination of vinegar and herbs toward the anti-acetylcholinesterase and antiinflammatory activities. However, vinegar added with 3% of Akebia quinata young leaves extract was demonstrated to show excellent biological activities [10]. It is due to the presence of phenolic compounds in both combinations of extracts.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on Anti-Acetylcholinesterase and Anti-Inflammatory Activities of Date and Apple Vinegars Fortified with Centella Asiatica

Adenan¹,

Jusril²,

Radzun³

et al. 2019

IJET

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Neuroinflammation and deficiency of cholinergic are major factors of neurodegenerative damage correlated to cognitive impairment in Alzheimer’s disease (AD). We investigated the anti-inflammatory and anti-acetylcholinesterase activities of apple and date vinegars added with Centella asiatica in SH-SY5Y neuroblastoma cells. The neuroprotective effect of apple or date vinegar added with various percentage of C. asiatica (0, 0.5, 2, 5) % w/v was determined in vitro. The methanolic extract of apple vinegar added with 2% C. asiatica (AV-2% CA) and date vinegar added with 2% C. asiatica (DV-2% CA) extracts showed potent neuroprotective effect. Both extracts were subjected to liquid-liquid partitioning yielded aqueous (H2O: AV/DV-2% CA) and ethyl acetate (EA: AV/DV-2% CA) extracts. Anti-inflammatory response against nitric oxide (NO) of all extracts was measured in LPS-induced SH-SY5Y neuroblastoma cells and percentage inhibition of acetylcholinesterase (AChE) was measured using commercially available test kits. It was found that EA: DV-2% CA showed potent ameliorating effect against LPS-induced inflammation (I50: 563.5 ± 0.13μg/mL) and was also responsible in the AChE inhibition activity (IC50: 9.087 ± 0.02). Thus, this extract is suggested to have dual properties of anti-inflammatory and anti-acetylcholinesterase inhibition activity that could be beneficial in the treatment and prevention of neurodegenerative disease.

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Quality Characteristics and Biological Activities of Vinegars Added with Young Leaves of Akebia quinata

Cited by 7 publications

References 31 publications

Fermentation Characteristics of Unripe Citrus unshiu Vinegar Production Using Acetic Acid Bacteria Isolated from Traditional Fermented Vinegars

Fermentation Characteristics of Unripe Citrus unshiu Vinegar Production Using Acetic Acid Bacteria Isolated from Traditional Fermented Vinegars

Phenolic Profile and Fingerprint Analysis of Akebia quinata Leaves Extract with Endothelial Protective Activity

Comparative Study on Anti-Acetylcholinesterase and Anti-Inflammatory Activities of Date and Apple Vinegars Fortified with Centella Asiatica

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