In order to determine the water quality of Danube River, in the Galati area, the Water Quality Index was calculated. Water Quality Index is a useful number of overall qualities of water. Galati is a Danube port city located in south-eastern of Romania. Samples were taken from 9 places along the Danube starting with the place where the Siret flows into the Danube to the Profiland Steel Plant. Profiland Steel is a company in Galai whose main activities are: sheet and zinc strips; treatment and coating of metals. The monitoring period was one year, from November 2016 to December 2017. Every month, thirty physical - chemical parameters were investigated. In this study the assessment of surface water quality was determined on the basis of various indicators such as: potassium and calcium ions, nitrites, nitrates, total nitrogen, ammonium, chlorides, total phosphorus, sulphates, cadmium, chrome, copper, lead, iron, zinc, density, dissolved oxygen, chemical oxygen demand (CCO-Cr), biochemical oxygen demand (CBO5), electrical conductivity, the density of the conductivity, resistivity, pH, salinity, total dissolved solids. The water quality index (WQI) has been calculated by using Weighted Arithmetic Water Quality Index Method. Two types of correlations were developed: Pearson correlation matrix and Spearman correlation.