Quality of life after long-term biochemical control of acromegaly

Kimball, Allison; Dichtel, Laura E.; Yuen, Kevin C.J.; Woodmansee, Whitney W.; Haines, Melanie S; Nachtigall, Lisa B.; Swearingen, Brooke; Jones, Pamela S.; Tritos, Nicholas A.; Sharpless, Julie L.; Kaiser, Ursula B.; Gerweck, Anu V.; Miller, Karen K.

doi:10.1007/s11102-022-01224-0

Cited by 6 publications

(2 citation statements)

References 30 publications

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Section: Discussionmentioning

confidence: 99%

“…Noteworthy, controversial results have been reported, since the poor quality of life seen at diagnosis of acromegaly has been demonstrated either to persist despite long-term remission regardless of the treatment used to achieve biochemical control (109)(110)(111)(112)(113), or to improve after GH and IGF-I normalization (114)(115)(116). Lower AcroQol scores have been reported in patients with long disease duration (109,112), multiple comorbidities (117) and in women (118). Partly in agreement with these findings, the results of the current study have demonstrated that in patients with partial disease control AcroQol scores, specifically those related to body image quality, were significantly lower as compared to patients with full or absent disease control, thus suggesting a limited role for the achievement of disease control on the full recovery of quality of life in all specific domains.…”

Section: Discussionmentioning

confidence: 99%

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Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study

Pivonello

Auriemma

Veneri

et al. 2022

European Journal of Endocrinology

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Objective: Acromegaly is associated with somatic disfigurements which impair self-perception of well-being and quality of life. Nowadays limited data are available on the interplay between hormonal excess and psychological discomfort. The study aimed at investigating the psychological profile, sleep quality, sexual function, cognitive functions, and quality of life in acromegaly. Methods: in 223 acromegaly patients from five referral centres global psychological profile, sleep quality, sexual function, cognitive function, and quality of life were investigated. Results: depression was found in 30% of patients, and anxiety in two-thirds, together with severe discomfort in body image mainly in women. Obstructive sleep apnea syndrome (OSAS)risk and sleep disorders were found in >50% of patients, and daily sleepiness in 20%. Sexual dysfunction was reported in most patients, with the most severe impairment in women. Cognitive functions were compromised in 10% of cases. Disease duration, patient age and gender were the main determinants of such psychological effects. Depression (p=0.047), somatic affective mood lowering (p=0.021), state (p<0.001) and trait (p=0.013) anxiety, and body image distortion at Body Uneasiness Test (BUT) A (p<0.001) and B (p=0.006) were significantly worsened in patients <45 years, and slightly worsen in those diagnosed <2 years before. International Index for Erectile Function (IIEF)-15 (p<0.001) and Female Sexual Function Index (FSFI) (p<0.001) scores were significantly worsened in patients >64 years and slightly worsened in those diagnosed >10 years before, particularly in presence of cardiometabolic and respiratory complications. Cognitive symptoms were slightly worsened in older patients and in those with long disease. Conclusions: Acromegaly is associated with a relevant impairment of psychological profile persisting despite remission and long-term medical treatment.

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