Quality of Life After Oral Cancer Resection and Free Flap Reconstruction

Wang, Shuai; Yin, Shou-Cheng; Zhang, Ze-liang; Su, Xingzhou; Xu, Zhongfei

doi:10.1016/j.joms.2019.02.029

Cited by 20 publications

(10 citation statements)

References 30 publications

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“…Although most of the articles include the classic ALT and RFFF flaps, 11,12 comparison of S-ALT, MSAP, or SCIP seem to be very few. These flaps are usually compared individually with the workhorse RFFF.…”

Section: Discussionmentioning

confidence: 99%

“…This questionnaire is validated and frequently used to assess quality of life in patients with head and neck cancer. [10][11][12] Moreover, the Turkish version of UW-QOL has been shown to be valid and can be used in clinical trials in Turkish patients with head and neck cancer. 13 The scale consists of 12 diseasespecific (pain, appearance, activity, recreation, swallowing, chewing, speech, shoulder, taste, saliva, mood, and anxiety) questions.…”

Section: Methodsmentioning

confidence: 99%

“…This questionnaire is validated and frequently used to assess quality of life in patients with head and neck cancer 10–12. Moreover, the Turkish version of UW-QOL has been shown to be valid and can be used in clinical trials in Turkish patients with head and neck cancer 13.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of Current Free Flap Options for Intraoral Lining and Tongue Reconstruction

Gur

Tiftikçioğlu

Öztürk

et al. 2022

Journal of Craniofacial Surgery

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Free flaps have become the main alternative for intraoral reconstruction in current practice. However, controversy exists on pros and cons of different free flap options for this challenging area. Although there are various studies focusing on different free flap options, comparative studies are very few and there is not a single study comparing all 4 thin free flap options for intraoral reconstruction. Between 2018 and 2021, 30 patients underwent intraoral reconstruction. Four pliable and thin flaps, medial sural artery perforator flap, superficial circumflex iliac artery perforator flap, radial forearm free flap, and superthin anterolateral thigh flap were used for reconstructions and compared per functionality and patients’ quality of life. One medial sural artery perforator flap and 1 superficial circumflex iliac artery perforator flap failed because of perfusion problems, and the remaining flaps survived. Harvest time and donor site closure were with significant difference (P<0.05) between groups. Quality of life results were similar except one of the disease-specific questions. In authors’ opinion, anterolateral thigh flap is the best option in normal-weight individuals because of its reliability, pliability, and constant reliable vascular structure. Although other options may be considered in overweighted patients, thinly elevated anterolateral thigh flap still seems to be the most reliable option.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Comparison of Current Free Flap Options for Intraoral Lining and Tongue Reconstruction

Gur

Tiftikçioğlu

Öztürk

et al. 2022

Journal of Craniofacial Surgery

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“…OSCC, one of the most common epithelial malignancies in head and neck squamous cell carcinoma (HNSCC) [29], exerts an adverse influence on the appearance and life quality of patients [30,31]. It often involves the tongue, lips and the floor of mouth and easily spreads to regional lymph nodes and/or distant organs [9,32,33].…”

Section: Discussionmentioning

confidence: 99%

Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma

Yang

Liang

et al. 2019

EBioMedicine

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BackgroundOral squamous cell carcinoma (OSCC) is one of the most common malignant tumors worldwide. Patients with poorly differentiated OSCC often exhibit a poor prognosis. AUNIP (Aurora Kinase A and Ninein Interacting Protein), also known as AIBp, plays a key role in cell cycle and DNA damage repair. However, the function of AUNIP in OSCC remains elusive.MethodsThe differentially expressed genes (DEGs) were obtained using R language. Receiver operating characteristic curve analysis was performed to identify diagnostic markers for OSCC. The effectiveness of AUNIP in diagnosing OSCC was evaluated by machine learning. AUNIP expression was analyzed in publicly available databases and clinical specimens. Bioinformatics analysis and in vitro experiments were conducted to explore biological functions and prognostic value of AUNIP in OSCC.FindingsThe gene integration analysis revealed 90 upregulated DEGs. One candidate biomarker, AUNIP, for the diagnosis of OSCC was detected, and its expression gradually increased along with malignant differentiation of OSCC. Bioinformatics analysis demonstrated that AUNIP could be associated with tumor microenvironment, human papillomavirus infection, and cell cycle in OSCC. The suppression of AUNIP inhibited OSCC cell proliferation and resulted in G0/G1 phase arrest in OSCC cells. The survival analysis showed that AUNIP overexpression predicted poor prognosis of OSCC patients.Interpretation: AUNIP could serve as a candidate diagnostic and prognostic biomarker for OSCC and suppression of AUNIP may be a potential approach to preventing and treating OSCC.FundTaishan Scholars Project in Shandong Province (ts201511106) and the National Natural Science Foundation of China (Nos. 61603218).

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“…Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in the head and neck region, which impairs the quality of life 1 , 2 . Over the past 30 years, the age-standardized incidence rate was 6.2 and 3.6 per 100,000 for males and females, respectively, and the age-standardized death rate was 3.3 and 1.6 per 100,000 for males and females, respectively 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

Prognostic and therapeutic prediction by screening signature combinations from transcriptome–methylome interactions in oral squamous cell carcinoma

Shi

Liu

Tian

et al. 2022

Sci Rep

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DNA methylation pattern in oral squamous cell carcinoma (OSCC) remains poorly described. This study aimed to perform a genome-wide integrated analysis of the transcriptome and methylome and assess the efficacy of their prognostic signature model in patients with OSCC. We analyzed transcriptome and methylome data from 391 OSCC samples and 41 adjacent normal samples. A total of 8074 differentially expressed genes (DEGs) and 10,084 differentially expressed CpGs (DMCpGs) were identified. Then 241 DEGs with DMCpGs were identified. According to the prognostic analysis, the prognostic signature of methylation-related differentially expressed genes (mrDEGPS) was established. mrDEGPS consisted of seven prognostic methylation-related genes, including ESRRG, CCNA1, SLC20A1, COL6A6, FCGBP, CDKN2A, and ZNF43. mrDEGPS was a significant stratification factor of survival (P < 0.00001) irrespective of the clinical stage. The immune effector components, including B cells, CD4+ T cells, and CD8+ T cells, were decreased in the tumor environment of patients with high mrDEGPS. Immune checkpoint expressions, including CTLA-4, PD-1, LAG3, LGALS9, HAVCR2, and TIGHT, were comprehensively elevated (P < 0.001). The estimated half-maximal inhibitory concentration difference between low- and high-risk patients was inconsistent among chemotherapeutic drugs. In conclusion, the transcriptome–methylome interaction pattern in OSCC is complex. mrDEGPS can predict patient survival and responses to immunotherapy and chemotherapy and facilitate clinical decision-making in patients with OSCC.

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Quality of Life After Oral Cancer Resection and Free Flap Reconstruction

Cited by 20 publications

References 30 publications

Comparison of Current Free Flap Options for Intraoral Lining and Tongue Reconstruction

Comparison of Current Free Flap Options for Intraoral Lining and Tongue Reconstruction

Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma

Prognostic and therapeutic prediction by screening signature combinations from transcriptome–methylome interactions in oral squamous cell carcinoma

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