Quality of Life After Whole Pelvic Versus Prostate-Only External Beam Radiotherapy for Prostate Cancer: A Matched-Pair Comparison

Pinkawa, Michael; Piroth, Marc D.; Holý, Richard; Fischedick, Karin; Klotz, Jens; Székely-Orbán, Dalma; Eble, Michael J.

doi:10.1016/j.ijrobp.2010.05.054

Cited by 29 publications

(17 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the N00CA bowel function assessment are similar to those reported elsewhere from randomized studies [24–29] and nonrandomized studies [7, 16, 30]. All have shown significantly worse outcomes for bowel function after pelvic radiotherapy.…”

Section: Discussionsupporting

confidence: 81%

“…An awareness of symptoms that are most important to patients can also facilitate counseling after radiotherapy. For example, bleeding is often encountered during and after a course of PR [1, 3, 4, 16, 28, 29], and the present study shows that most patients consider this an important symptom that may also be associated with diminished QOL. If serious other causes of rectal bleeding have been excluded, clinicians will be in a better position to provide reassurance to patients with regard to the clinical significance of this symptom.…”

Section: Discussionmentioning

confidence: 53%

See 1 more Smart Citation

Assessment of patient-reported measures of bowel function before and after pelvic radiotherapy: an ancillary study of the North Central Cancer Treatment Group study N00CA

Atherton

Halyard

Sloan

et al. 2012

Support Care Cancer

View full text Add to dashboard Cite

Purpose The Bowel Function Questionnaire (BFQ) has been used in clinical trials to assess symptoms during and after pelvic radiotherapy (RT). This study evaluated the importance of symptoms in the BFQ from a patient perspective. Methods Patients reported presence or absence of symptoms and rated importance of symptoms at baseline, 4 weeks after completion of pelvic RT, and 12 and 24 months after RT. The BFQ measured overall quality of life (QOL) and symptoms of nocturnal bowel movements, incontinence, clustering, need for protective clothing, inability to differentiate stool from gas, liquid bowel movements, urgency, cramping, and bleeding. Bowel movement frequency also was recorded. A content validity questionnaire was used to rate symptoms as “not very important,” “moderately unimportant,” “neutral,” “moderately important,” or “very important.” Results Most of the 125 participating patients rated all symptoms as moderately or very important. Generally, patients gave similar ratings for symptom importance at all study points, and ratings were independent of whether the patient experienced the symptom. Measures of greatest importance (moderately or very important) at baseline were ability to control bowel movements (94%), not having to wear protective clothing (90%), and not having rectal bleeding (94%). With the exception of need for protective clothing, the presence of a symptom at 4 weeks was associated with significantly worse QOL (P<.01 for all). Conclusions The BFQ has excellent content validity. Patients rated most symptoms as moderately or very important, indicating the BFQ is an appropriate tool for symptom assessment during and after pelvic RT.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 53%

Assessment of patient-reported measures of bowel function before and after pelvic radiotherapy: an ancillary study of the North Central Cancer Treatment Group study N00CA

Atherton

Halyard

Sloan

et al. 2012

Support Care Cancer

View full text Add to dashboard Cite

show abstract

“…18,24 Changes in mean QoL scores of less than 10 points were defined as not clinically relevant, 10-20 points as a 'moderate' change and >20 points as a 'substantial' change. We interpreted our results according to the method described by Osoba et al, which has been used widely in HRQoL research.…”

Section: Methodsmentioning

confidence: 99%

Health‐related quality of life using intensity‐modulated radiation therapy for post‐prostatectomy radiotherapy

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Only patients with questionnaire results from both time A and time D were included in the analysis, resulting in an initial group of 362 patients after 3DCRT (whole pelvic treatment in 61 cases) [20,21] and 78 patients after IMRT (whole pelvic treatment with IMRT as a boost in 16 cases, IMRT as a boost following 3DCRT up to a dose of 60 Gy in 44 cases, IMRT for the complete treatment in 18 cases). For each patient in the IMRT subgroup, a 3DCRT patient was matched according to the following criteria: age ± 5 years, use of antiandrogens, treatment volume (± whole pelvis), prognostic risk group, and urinary/bowel/sexual QoL (function score preferably ± 10 points) before treatment.…”

Section: Methodsmentioning

confidence: 99%

Combination of Dose Escalation with Technological Advances (Intensity-Modulated and Image-Guided Radiotherapy) Is Not Associated with Increased Morbidity for Patients with Prostate Cancer

et al. 2011

Self Cite

View full text Add to dashboard Cite

Purpose:The aim was to evaluate treatment-related morbidity after intensity-modulated (IMRT) and image-guided (IGRT) radiotherapy with a total dose of 76 Gy in comparison to conventional conformal radiotherapy (3DCRT) up to 70.2-72 Gy for patients with prostate cancer. Patients and Methods: All patients were prospectively surveyed prior to, on the last day, as well as after a median time of 2 and 16 months after RT using a validated questionnaire (Expanded Prostate Cancer Index Composite). Criteria for the 78 matched pairs after IMRT vs. 3DCRT were patient age, use of antiandrogens, treatment volume (± whole pelvis), prognostic risk group, and urinary/bowel/sexual quality of life (QoL) before treatment. Results: QoL changes after dose-escalated IMRT were found to be similar to QoL changes after 3DCRT in all domains. Only sexual function scores more than 1 year after RT decreased slightly more after 3DCRT in comparison to IMRT (mean 9 vs. 6 points; p = 0.04), with erections firm enough for intercourse in 14% vs. 30% (p = 0.03). Painful bowel movements were reported more frequently after 3DCRT vs. IMRT 2 months after treatment (≥ once a day in 10% vs. 1%; p = 0.03), but a tendency for higher rectal bleeding rates was found after IMRT vs. 3DCRT more than 1 year after RT (≥ rarely in 20% vs. 9%; p = 0.06). Conclusion: Combination of dose escalation with technological advances (IMRT and IGRT) is not associated with increased morbidity for patients with prostate cancer. Verknüpfung einer Dosiseskalation mit technologischen Fortschritten (intensitätsmodulierte und bildgeführte Radiotherapie) ist bei Patienten mit Prostatakarzinom nicht mit erhöhter Morbidität assoziiertZiel: Ziel war die Analyse therapiebedingter Morbidität nach intensitätsmodulierter (IMRT) und bildgeführter (IGRT) Radiotherapie mit einer Gesamtdosis von 76 Gy im Vergleich zur konventionellen konformalen Radiotherapie (3DCRT) bis 70,2-72 Gy bei Patienten mit einem Prostatakarzinom. Patienten und Methoden: Alle Patienten wurden prospektiv vor Beginn, am letzten Tag, median 2 Monate und 16 Monate nach RT mittels eines validierten Fragebogens befragt (Expanded Prostate Cancer Index Composite). Kriterien für 78 gematchte Paare nach IMRT vs. 3DCRT waren das Patientenalter, der Einsatz eines Antiandrogens, Zielvolumen (± Becken), prognostische Risikogruppe und Lebensqualität (LQ) beim Wasserlassen/Stuhlgang/Sexualität vor der Behandlung. Ergebnisse: LQ-Veränderungen nach dosiseskalierter IMRT waren den LQ-Veränderungen nach 3DCRT in allen Domänen sehr ähnlich. Nur der Punktwert für die sexuelle Funktion fiel über ein Jahr nach der Behandlung nach 3DCRT etwas mehr als nach IMRT (durchschnittlich 9 vs. 6 Punkte; p = 0,04), mit ausreichender Erektion für Geschlechtsverkehr in 14% vs. 30% (p = 0,03). Schmerzhafter Stuhlgang wurde zwei Monate nach Therapie häufiger nach 3DCRT als nach IMRT berichtet (≥1-mal täglich in 10% vs. 1%; p = 0,03); jedoch fand sich über ein Jahr nach RT die Tendenz zu einer häufigeren Rate rektaler Blutungen nach IMRT als nach 3DCRT (≥ s...

show abstract

Quality of Life After Whole Pelvic Versus Prostate-Only External Beam Radiotherapy for Prostate Cancer: A Matched-Pair Comparison

Cited by 29 publications

References 25 publications

Assessment of patient-reported measures of bowel function before and after pelvic radiotherapy: an ancillary study of the North Central Cancer Treatment Group study N00CA

Assessment of patient-reported measures of bowel function before and after pelvic radiotherapy: an ancillary study of the North Central Cancer Treatment Group study N00CA

Health‐related quality of life using intensity‐modulated radiation therapy for post‐prostatectomy radiotherapy

Combination of Dose Escalation with Technological Advances (Intensity-Modulated and Image-Guided Radiotherapy) Is Not Associated with Increased Morbidity for Patients with Prostate Cancer

Contact Info

Product

Resources

About