Quality of life among women with epilepsy during their reproductive years

Santos, Ana Maria Cruz; Castro-Lima, Humberto; Matos, Marcos Almeida; Brito, Milena Bastos

doi:10.1016/j.yebeh.2018.04.028

Cited by 8 publications

(10 citation statements)

References 22 publications

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“…These results are in line with previous studies which found that good seizure control was significantly related with higher health-related quality of life. [4][5][6] A possible reason is that the patients with more seizure frequencies were more likely to be unsatisfied and inconvenient about taking antiepileptic drugs than those free from seizure. Based on univariate and multivariate analyses, education and employment status were not significantly associated with all 8 PROMPT-QoL domain scores.…”

Section: Associations Between Medication-related Quality Of Life and mentioning

confidence: 99%

“…3 Epilepsy can have an extremely negative impact on patients' quality of life due to seizure frequency and adverse effects of antiepileptic drugs. [4][5][6] Nevertheless, up to 70% of people living with epilepsy could live seizure-free with appropriate use of antiepileptic drugs. 1 Therefore, antiepileptic drugs can have both pos-itive and negative effects on patients' lives, so assessment medication-related quality of life in patients with epilepsy is essential.…”

Section: Introductionmentioning

confidence: 99%

“…6 Hence, previous studies in this area have not extensively assessed medication-related quality of life in patients with epilepsy. [4][5][6] A novel generic questionnaire called Patient-Reported Outcomes Measure of Pharmaceutical Therapy for Quality of Life (PROMPT-QoL) was developed. 8 It was originally in Thai and was mainly created by applying the concept of patient-centered pharmaceutical care.…”

Section: Introductionmentioning

confidence: 99%

“…Little was also known about associations between medication-related quality of life and patient characteristics in epilepsy patients since most previous studies assessed the relationships with health-related quality of life, non-specific medication measures. [4][5][6][12][13][14][15] Hence, the second objective was to evaluate such associations. This information will be helpful for healthcare providers to manage medication therapy for epilepsy patients.…”

Section: Introductionmentioning

confidence: 99%

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Medication-Related Quality of Life in Thai Epilepsy Patients

Sakthong¹,

Suriyapakorn²

2020

J Epilepsy Res

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Background and Purpose: This study aimed to assess medication-related quality of life in Thai patients with epilepsy. The second objective was to evaluate the associations between the medication therapy-related quality of life and patient characteristics. Methods: This was a cross-sectional study. A convenience sample of 173 outpatients with epilepsy was recruited from a university hospital in Bangkok, Thailand. Inclusion criteria were aged 18 or over who were continuously taking an epileptic drug for at least 3 months, understanding Thai language, and willing to participate in the study. The Patient-Reported Outcomes Measure of Pharmaceutical Therapy for Quality of Life (PROMPT-QoL) was utilized to measure the medication therapy-related quality of life. Pearson's correlation coefficients and stepwise multiple linear regressions were employed to assess the relationships between eight PROMPT-QoL domain scores and patient demographic and clinical characteristics. Results: Mean age was 36.4±9.5 years and approximately 57% were female. Among eight domains of the PROMPT-QoL, the therapeutic relationships with health care providers and psychological impacts of medication use domains yielded the highest (77.9) and lowest (61.9) mean scores, respectively. Seven out of eight PROMPT-QoL domain scores were considered as moderate-to-good. Age, gender, duration of epilepsy, seizure frequency, and treatment preference were significantly associated with PROMPT-QoL domain scores in multivariate linear regression analyses. Conclusions: This study showed that Thai patients with epilepsy had moderate-to-good medication therapy-related quality of life. Healthcare providers should pay more attention to patients' psychological impacts of antiepileptic drugs and those with characteristics related to lower medication therapy-related quality of life. (2019;9:139-146)

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Section: Associations Between Medication-related Quality Of Life and mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Medication-Related Quality of Life in Thai Epilepsy Patients

Sakthong¹,

Suriyapakorn²

2020

J Epilepsy Res

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“…Additionally, patients' treatment adherence depends on many factors, including efficacy, adverse effects, safety, ease of use, and costs, especially the adverse effects like nausea, vomiting, dizziness, tremor, skin rash, memory problems, and cognitive impairment (5)(6)(7). Furthermore, drugs' seizures and adverse effects can affect health-related quality of life (HRQOL) and patients' satisfaction (8). In practice, drug selection is mainly determined by the doctor without considering patients' opinions that mattered.…”

Section: Introductionmentioning

confidence: 99%

Patient Preference for Antiepileptic Drugs Treatment in China: Evidence From the Discrete Choice Experiment

Hua

Zhu

et al. 2020

Front. Neurol.

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Objective: Explore Chinese patients' risk-benefit preferences and willingness-to-pay (WTP) for antiepileptic drugs (AEDs) treatment through the discrete choice experiment (DCE).Method: Six attributes including the efficacy of AEDs, adverse reactions (digestive system, neuropsychic systems, and the effects on the fetus), dosing frequency and drug costs (to estimate patient WTP) were included in the DCE questionnaire based on results collected from literature reviews, expert consultation, and patient survey. The alternative-specific conditional logit model was used to analyze patient preference and WTP for each attribute and its level and to assess the sociodemographic impact and clinical characteristics.Results: A total of 151 valid questionnaires were collected. The result shows that five out of the six attributes are significant, except the dosing frequency. Among the six attributes, the efficacy of AEDs (10.0; 95% CI 8.9–11.1) is mostly concerned by patients, followed by the effects of AEDs on the fetus (8.9; 95% CI 7.7–10.1), duration of side effects in the neuropsychic system (4.9; 95% CI 3.7–6.0) and adverse reactions of the digestive system (3.2; 95% CI 1.5–4.2). The patients surveyed are willing to spend ¥ 1,246 (95% CI, ¥ 632- ¥ 1,861) per month to ensure 100% seizure control, and ¥ 1,112 (95% CI, ¥ 586–¥ 1,658) to reduce the risk of the drug affecting the fetus to 3%. Besides, it was found that personal characteristics including the intention for conception and AEDs treatment regimens have statistical significance.Conclusion: Improving the drug's efficacy and reducing its side effects are predominant considerations for patients with epilepsy in China, especially for those who are concerned about the seizure control and the drug effect on the fetus. This finding is useful to physicians and can encourage shared decision-making between the patients and their doctors in the clinic.

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Perceived quality of life (QOLIE-31-P), depression (NDDI-E), anxiety (GAD-7), and insomnia in patients with epilepsy attended at a refractory epilepsy unit in real-life clinical practice

et al. 2021

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Objectives This study aims to evaluate the relationship between psychiatric comorbidity (anxiety and depression), somnolence, and quality of life, using validated scales in patients with epilepsy in real-life clinical practice and clinical and demographic variables. Methods A cross-sectional observational study was conducted. Self-administered scales of anxiety disorders (GAD-7), depression (NDDI-E), somnolence (Epworth Sleepiness Scale (ESS)), and quality of life (QOLIE-31-P) in patients with epilepsy treated in the refractory epilepsy unit of a tertiary hospital were employed. Results Eighty-four patients, 44.3 ± 17.4 years, 48.2% women, epilepsy duration 21.5 ± 15.9 years, and number of antiepileptic drugs 1.9 ± 1.2 were included. Severe anxiety was present in 14.3%, depression in 20.2%, and somnolence in 14.3% of patients. QOLIE-31-P score was 62.0 ± 19.2. Depression and focal epilepsy ( OR = 4.5[1.3, 20.7], p = 0.029), as well as anxiety and temporal lobe epilepsy ( OR = 4.3 [1.0, 18.1], p = 0.044), were associated. Moreover, relationships between worse quality of life and higher scores from NDDI-E ( β = − 1.42, adjusted p = 0.006) and GAD-7 ( β = − 1.21, adjusted p = 0.006), especially in drug-resistant epilepsy ( β = − 8.08, adjusted p = 0.045) and female sex ( β = − 7.83, adjusted p = 0.034), were identified. Statistically significant negative associations were observed between problems to fall asleep and overall quality of life score ( β = − 11.64, adjusted p = 0.022), sleep disturbance and energy ( β = − 14.78, adjusted p = 0.027), and mood ( β = 12.40, adjusted p = 0.027) scores. Conclusions The multidimensional evaluation revealed that higher levels of anxiety and depression are associated with worse quality of life in real clinical practice in patients with epilepsy, especially in females and drug-resistant epilepsy. In addition, sleep disturbances are associated with particular aspects of the quality of life. Further studies with longitudinal follow-up would be useful to adequately manage these comorbidities in patients with epilepsy. Supplementary Information The online version contains supplementary material available at 10.1007/s10072-021-05595-3.

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Quality of life among women with epilepsy during their reproductive years

Cited by 8 publications

References 22 publications

Medication-Related Quality of Life in Thai Epilepsy Patients

Medication-Related Quality of Life in Thai Epilepsy Patients

Patient Preference for Antiepileptic Drugs Treatment in China: Evidence From the Discrete Choice Experiment

Perceived quality of life (QOLIE-31-P), depression (NDDI-E), anxiety (GAD-7), and insomnia in patients with epilepsy attended at a refractory epilepsy unit in real-life clinical practice

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