Quality of life in 1000 patients with early relapsing–remitting multiple sclerosis

Putzki, Norman; Fischer, Jill S.; Gottwald, K.; Reifschneider, G.; Ries, Stefan; Siever, Arno; Hoffmann, F.; Käfferlein, W.; Kausch, U.; Liedtke, Michaela; Kirchmeier, J.; Gmünd, S.; Richter, Ann-Kathrin; Schicklmaier, P.; Niemczyk, Gabriele; Wernsdörfer, C.; Hartung, HP

doi:10.1111/j.1468-1331.2009.02572.x

Cited by 74 publications

(60 citation statements)

References 32 publications

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“…In this study, MS had marked impacts on social, domestic and occupational functioning, and on family life. These findings are consistent with those of previous studies showing significant impairment of social, domestic and work activities in MS patients [24][25][26]. Similarly, MS significantly affects the probability of remaining in the same relationship compared with the background population.…”

Section: Discussionsupporting

confidence: 83%

Impact of depression on multiple sclerosis patients

Leonavičius

Adomaitienė

2012

Open Medicine

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Section: Discussionsupporting

confidence: 83%

Impact of depression on multiple sclerosis patients

Leonavičius

Adomaitienė

2012

Open Medicine

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“…Expenditures for disease-modifying drugs (DMDs) are remarkably high in MS, reaching annual treatment costs of more than EUR 25,000 per patient [11]. Depending on the disability grade, MS decreases quality of life [12,13] and often causes a major handicap [14]. …”

Section: Introductionmentioning

confidence: 99%

Economic Burden in a German Cohort of Patients with Multiple Sclerosis

Reese

John²,

Wienemann³

et al. 2011

Eur Neurol

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Aims: To estimate costs of multiple sclerosis (MS) in a German cohort according to severity of the disease and clinical symptoms. Methods: 144 patients were recruited from an MS outpatient clinic. Costs were calculated according to current German health-economic guidelines from the perspective of the social health insurance system. Patients were either interviewed or completed a questionnaire. Cost assessment covered a 3-month period. Health outcomes were: Expanded Disability Status Scale, MS Functional Composite, Functional Assessment of MS, fatigue, depression (Beck Depression Inventory II) and patients’ socioeconomic status. Multivariate linear regression identified independent cost predictors. Results: Total quarterly costs per patient were EUR 10,329 (95% CI 9,357–11,390). Direct costs were EUR 5,344 for the social health insurance system and EUR 140 for the patient. Drugs represented the major share of direct costs (and 35% of total costs); indirect costs accounted for 47% of total costs. Univariate and multivariate analyses identified age, disability, fatigue and depression as independent predictors for total, indirect or drug costs. Conclusion: MS represents a high economic burden, with direct costs exceeding indirect costs. To reduce costs, research should focus on prevention that slows down progression of MS. Rehabilitation and symptomatic treatment may have merits in decreasing indirect costs.

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“…Putzki et al had conducted a comprehensive study of the relationships between MS and patients' professional activities. They investigated 1157 relapsing-remitting (RR) MS patients in an open label multicenter survey in Germany [45]. Jongen et al provided similar results in 2 years lasting survey which investigated 284 RRMS patients in 36 neurological centers [46].…”

Section: Discussionmentioning

confidence: 52%

“…Reports of the lifetime risk for depression in MS populations have ranged from 27% to 54% [9,10]. People with MS experience lower quality of life (QoL) and well-being levels than people from the general population in health-related QoL domains [11,12] and compared to those diagnosed with other chronic illnesses, such as epilepsy, diabetes, rheumatoid arthritis, and inflammatory bowel disease [13,14].…”

Section: Introductionmentioning

confidence: 99%

The relationships between depression and life activities and well-being of multiple sclerosis patients

2011

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AbstractMultiple sclerosis (MS) is one of the most disabling neurodegenerative disorders. Depression is the most frequent psychiatric disorder accompanying MS. Although much attention is given to correlations between depression and MS clinical factors, analysis of correlations between depression and life activities (social, household, professional activities and family life) and the well-being of MS patients’ is insufficient. However, improvement of these functions could positively influence the outcomes of MS treatment. The aim of this study was to evaluate relationships between depression, life activities of MS patients, and their proposals how to improve the well-being. Materials and methods. The study lasted three years with 270 adult MS patients involved in it. ICD-10 criteria were used to diagnose depression. Original questionnaire was used to measure life activities and the well-being of the patients. Results. Prevalence of depression was 20.7% with no difference regarding the gender. Almost 84% of depressed respondents indicated, that MS disturbs their family life, 71.4% recommended to assign more attention to MS in general and 64.3% — to include more medications into reimbursement list. Conclusions. MS patients diagnosed with depression significantly more often than non-depressed indicate that MS disturbs their family life; recommend to assign more attention to MS in general and to include more medications into reimbursement list.

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Quality of life in 1000 patients with early relapsing–remitting multiple sclerosis

Abstract: Quality of life is considerably impaired in early stages of MS. Treatment initiation with IM IFNbeta attenuates MS disease activity and improves QoL. Inability to work early during the disease is a major challenge for the social security systems.

Cited by 74 publications

References 32 publications

Impact of depression on multiple sclerosis patients

Impact of depression on multiple sclerosis patients

Economic Burden in a German Cohort of Patients with Multiple Sclerosis

The relationships between depression and life activities and well-being of multiple sclerosis patients

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