Quality of Life in Alzheimer’s Disease

Howard, Kellee; Rockwood, Kenneth

doi:10.1159/000106931

Cited by 37 publications

(16 citation statements)

References 14 publications

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“…The QOL scales used in these trials have either not been fully validated for use in dementia (Howard & Rockwood, 1995) and/or have assessed only some aspects of activities of daily living, or affect, rather than comprehensively assessing QOL . To date, no QOL instrument used in clinical trials of anti-dementia drugs appears to be satisfactory .…”

Section: Qol In Dementia: Recent Workmentioning

confidence: 99%

Assessing quality of life in dementia: Preliminary psychometric testing of the Quality of Life Assessment Schedule (QOLAS)

Selai¹,

Trimble²,

Rossor³

et al. 2001

Neuropsychological Rehabilitation

102

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We adapted a generic, individualised, patient-centred quality of life (QOL) assessment technique, the Quality of Life Assessment Schedule (QOLAS) for use with patients with dementia. The QOLAS was administered to a group of patients with mild to moderate dementia alongside a number of other measures of well-being to assess its psychometric properties. Each patient's main carer also completed the QOLAS, giving a proxy rating of the QOL of the patient. The patients understood the interview and were able to describe their quality of life both qualitatively and quantitatively. In this preliminary study the QOLAS was demonstrated to have good validity (content, construct, and criterion) and good internal reliability. The carers rated the patients as having a worse QOL than did the patients themselves on all subdomains of the QOLAS. The results suggest that patients with mild to moderate dementia can rate their own QOL and that the QOLAS is a promising method for assessing QOL in this patient group. The discrepancy between the patients' own views and the views of their carers raises important issues about whether the patient or a proxy is the best judge of QOL in patients with dementia.

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Section: Qol In Dementia: Recent Workmentioning

confidence: 99%

Assessing quality of life in dementia: Preliminary psychometric testing of the Quality of Life Assessment Schedule (QOLAS)

Selai¹,

Trimble²,

Rossor³

et al. 2001

Neuropsychological Rehabilitation

102

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“…Psychosocial multidisciplinary interventions for carers are cost-effective, improve carer's health and quality of life [60], and delay institutionalisation [61]. Carers benefit from acquiring skills and knowledge pertaining to the core tasks they perform and develop a sense of selfefficacy and confidence.…”

Section: Psychosocial Interventionsmentioning

confidence: 99%

Caring for dementia carers: the role of general practitioners in Ireland

O'Connor

2011

Ir J Med Sci

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“…Both types of measure have been used to assess the effects of antidementia treatment on QOL. Unfortunately, most scales have not Winblad/Wimo/Almkvist been validated adequately for use in patients with AD [70] and there is, as yet, no 'gold standard' assessment [71]. Nevertheless, improvement in QOL remains a treatment goal in AD, and efforts to develop and validate a practical measure should continue.…”

Section: Quality Of Lifementioning

confidence: 99%

Outcome Measures in Alzheimer’s Disease: Do They Go Far Enough?

Winblad

Wimo

Almkvist

2000

Dement Geriatr Cogn Disord

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As the interest in Alzheimer’s disease (AD) and its treatment has grown, so has the sophistication of clinical trials of potential drug therapies. In particular, interest has focused on outcomes used to assess the severity of the illness and the effectiveness of treatment. This paper reviews the assessments that are used frequently in trials of AD therapy and describes further measures that may be of value in determining effective treatments for the disease. The review concludes that it is important that evaluation of drug effects on AD is not confined solely to the assessment of cognitive function. To gain a true overview of the impact of AD on patients, carers and society, areas such as activities of daily living, caregiver burden, quality of life, behavioural symptoms and resource utilization need to be comprehensively determined.

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Quality of Life in Alzheimer’s Disease

Cited by 37 publications

References 14 publications

Assessing quality of life in dementia: Preliminary psychometric testing of the Quality of Life Assessment Schedule (QOLAS)

Assessing quality of life in dementia: Preliminary psychometric testing of the Quality of Life Assessment Schedule (QOLAS)

Caring for dementia carers: the role of general practitioners in Ireland

Outcome Measures in Alzheimer’s Disease: Do They Go Far Enough?

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