Quality of life in children receiving treatment for <i>Mycobacterium abscessus</i> otomastoiditis

Leow, Theresa Y.S.; Bekkers, Stijn; Janssen, A. Miranda L.; Pegge, Sjoert; Kunst, Henricus P. M.; Waterval, Jérôme J.; Jansen, Thijs; Henriet, Stefanie; Aerde, Koen van; Ingen, Jakko van; Hol, Myrthe K. S.

doi:10.1111/coa.13931

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…According to recent literature, in patients with M. abscessus otomastoiditis, quality of life may temporarily be poor due to treatment. Hearing loss with adverse events such as nausea and vomiting may be noted after antibiotic treatment or surgery [22]. In the cases investigated in our study, no obvious sequelae were observed during long-term follow-up after proper management.…”

Section: Discussionmentioning

confidence: 51%

Mycobacterial Infection in Recalcitrant Otomastoiditis: A Case Series and Literature Review

Tsai,

Lan,

Mao

et al. 2023

JCM

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Otomastoiditis caused by mycobacterial infections is uncommon and recalcitrant. Its clinical presentations, sometimes similar to those of common chronic suppurative otitis media, make diagnosis difficult. This retrospective study analyzed the clinical features, treatment course, and therapeutic outcomes of patients with mycobacterial otomastoiditis. The cases of six patients diagnosed with mycobacterial otomastoiditis or suspected mycobacterial infection between January 2007 and January 2019 in a single tertiary medical center in Taiwan were investigated. Information about predisposing factors, clinical features, culture reports, histopathology, treatment course, and outcomes were collected and analyzed. Relevant literature available in English was also reviewed. One patient was infected with tuberculous mycobacteria, two with suspected tuberculous mycobacteria, and three with nontuberculous mycobacteria. All six patients responded poorly to empiric antibiotic therapy, and diagnosis was not possible at their previous clinics. Five patients underwent tympanomastoidectomies; one was administered antimycobacterial medication without undergoing surgery. Mycobacterial infection was confirmed from a tissue culture or from the histopathology of the specimen, but in two patients, no definitive evidence of tuberculosis was found. Antimycobacterial medication was administered based on clinical suspicion, and improvement was noted. With appropriate therapy, all patients recovered, and no sequelae were observed after treatment. If empiric antibiotic therapy cannot achieve acceptable results, atypical infections, such as mycobacteria, should be considered. Antimycobacterial medication could be administered under clinical suspicion, serving as a diagnosis ex juvantibus. Surgical intervention might help reduce the bacterial load and obtain specimens for accurate diagnosis, but this may be unnecessary if appropriate antimycobacterial medication results in improvement. Early diagnosis and treatment can prevent complications in patients with recalcitrant otomastoiditis.

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Section: Discussionmentioning

confidence: 51%

Mycobacterial Infection in Recalcitrant Otomastoiditis: A Case Series and Literature Review

Tsai,

Lan,

Mao

et al. 2023

JCM

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Quality of life in children receiving treatment for Mycobacterium abscessus otomastoiditis

Leow

Bekkers

Janssen

et al. 2022

Clinical Otolaryngology

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Mycobacterium abscessus (M. abscessus) is a rapidly growing nontuberculous mycobacterium (NTM), often dubbed the 'antibiotic nightmare' for its extensive resistance to antibiotics. 1 Pulmonary infections, skin and soft tissue infections are its most frequent clinical manifestations, but otomastoiditis is also an established clinical entity. 2 Treatment is difficult due to the multidrug resistance and lack of international consensus on therapeutic options as well as duration of treatment.A previous study at our institute suggested a 6-month antibiotic treatment strategy combining systemic and local treatment. 3 This intensive, long-term antibiotic regimen proved effective, but severely affects children's wellbeing. Children need a peripherally inserted central catheter (PICC) for long-term intravenous antibiotics and both surgery and antibiotic treatment may induce hearing loss (HL).Adverse events (AE) such as nausea and vomiting, myelosuppression, toxic dermatitis and liver toxicity are frequent and the psychosocial impact of the treatment is thought to be the severe. 3 Therefore, the assessment of quality of life (QoL) during and after treatment is important. This study aims to evaluate adverse events and QoL after treatment for M. abscessus otomastoiditis. | ME THODS | DesignA retrospective analysis of QoL from patients treated for M. abscessus otomastoiditis at our referral centre was performed. Informed consent was obtained from the guardians and children above 12 years old. Guardians and patients were invited by phone.

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Quality of life in children receiving treatment for Mycobacterium abscessus otomastoiditis

Cited by 2 publications

References 13 publications

Mycobacterial Infection in Recalcitrant Otomastoiditis: A Case Series and Literature Review

Mycobacterial Infection in Recalcitrant Otomastoiditis: A Case Series and Literature Review

Quality of life in children receiving treatment for Mycobacterium abscessus otomastoiditis

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