Quality of life in “chronic” cancer survivors: a meta-analysis

Firkins, Jenny; Hansen, Lissi; Driessnack, Martha; Dieckmann, Nathan F.

doi:10.1007/s11764-020-00869-9

Cited by 173 publications

(122 citation statements)

References 91 publications

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“…The number of cancer survivors is increasing due to earlier detection, better treatment options, and demographic aging [ 1 , 2 ]. Cancer may be considered a chronic disease [ 3 , 4 ] as it can affect survivors’ lives and health-related quality of life (HRQoL) for years [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…A meta-analysis that included more than 60 studies found that, on average, long-term cancer survivors (LTCS) showed medium-to-large detriments in most HRQoL domains compared to the normative data, with the largest detriments in role-physical health (i.e., difficulties accomplishing activities of daily living and working) [ 3 ]. However, the studies included in the review were heterogeneous regarding their definitions of long-term cancer survivorship (participants were 2–26 years post-diagnosis), and many did not include population controls or compared the HRQoL of LTCS with published normative data of specific questionnaires that do not take into account the age structure of LTCS [ 3 ]. Furthermore, long-term survivorship often includes recurrence and relapse states [ 4 ], which should also be considered when analyzing the HRQoL.…”

Section: Introductionmentioning

confidence: 99%

“…However, pertinent studies that specifically addressed HRQoL and that included VLTCS often did not include age-matched controls [ 17 , 18 , 19 , 20 , 21 , 22 ], focused on specific cancer sites [ 16 , 18 , 19 , 20 , 21 , 22 , 23 ], or were limited to certain age ranges [ 18 , 19 , 20 , 24 ], UICC/cancer stages [ 19 , 22 , 24 ], or treatments [ 19 , 23 ]. As such, more research is needed to understand the moderators of the HRQoL in VLTCS [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study

Doege

Thong

Weißer

et al. 2021

Cancers

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(1) Background: Little is known about the health-related quality of life (HRQoL) in very long-term cancer survivors (VLTCS) 10 and more years post-diagnosis. The objective was to compare cancer survivors’ HRQoL 14–24 years post-diagnosis with that of same-aged non-cancer controls, stratified by age, sex, and disease status (disease-free vs. stage IV, recurrence, metastasis, or second cancer). (2) Methods: We recruited 2704 very long-term survivors of breast, colorectal and prostate cancer, and 1765 controls in German multi-regional population-based studies. The HRQoL was assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Differences in the HRQoL were estimated with multiple regression, controlling for age, sex (where appropriate), and education. (3) Results: The overall global health status/quality of life of VLTCS more than a decade after diagnosis was slightly higher than that of population controls of the same age, but more symptoms and lower functioning were reported. Differences were small but statistically significant. Results differed by age, sex, and disease status. (4) Conclusions: The findings point out the need for a comprehensive survivorship care program in order to monitor and treat potential late and long-term effects after the diagnosis and treatment of cancer. Survivorship care should be risk-adapted to survivors’ needs according to sociodemographic and clinical factors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study

Doege

Thong

Weißer

et al. 2021

Cancers

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“…Our previous research and those from the published literature suggest that lung and colorectal cancer survivors suffer from persistent long-term effects of treatment, such as dyspnea, fatigue, pain/neuropathy, bowel dysfunction, ostomy care, anxiety, depression, and distress. These symptoms contribute to a dramatic deterioration in post-primary treatment quality of life (QOL) [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Rationale and Design of a Telehealth Self-Management, Shared Care Intervention for Post-treatment Survivors of Lung and Colorectal Cancer

et al. 2021

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Survivors of lung and colorectal cancer have high post-treatment needs; the majority are older and suffer from greater comorbidities and poor quality of life (QOL). They remain underrepresented in research, leading to significant disparities in post-treatment outcomes. Personalized post-treatment follow-up care and care coordination among healthcare teams is a priority for survivors of lung and colorectal cancer. However, there are few evidence-based interventions that address survivors’ post-treatment needs beyond the use of a follow-up care plan. This paper describes the rationale and design of an evidence-informed telehealth intervention that integrates shared care coordination between oncology/primary care and self-management skills building to empower post-treatment survivors of lung and colorectal cancer. The intervention design was informed by (1) contemporary published evidence on cancer survivorship, (2) our previous research in lung and colorectal cancer survivorship, (3) the chronic care self-management model (CCM), and (4) shared post-treatment follow-up care between oncology and primary care. A two-arm, parallel randomized controlled trial will determine the efficacy of the telehealth intervention to improve cancer care delivery and survivor-specific outcomes. ClinicalTrials.govIdentifier: NCT04428905

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“…Follow-up strategies for Bcell neoplasms are based on expert consensus and observational studies, due to the absence of supporting evidence from controlled clinical trials [5][6][7]10]. Many patients experience frequent, non-specific symptoms, treatment-related complications, and other healthrelated issues associated with cancer survivorship [11][12][13][14]. For example, many cancer survivors experience significant fatigue, neuropathy, and anxiety related to a fear of recurrence [15,16]; all of these symptoms can have a negative impact on the quality of life [13].…”

Section: Introductionmentioning

confidence: 99%

Shared care follow-up of patients with B-cell neoplasms based on nurse-led telephone consultations and PRO-data: a feasibility study from the North Denmark Region

Sommer

Frandsen

Jensen

et al. 2020

BMC Health Serv Res

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Background Patients with B-cell neoplasms in remission are monitored with regular physician visits at the hospital. The current standard follow-up procedure is not evidence-based or individualized to patient needs. To improve and individualize the follow-up, we investigated the feasibility of a shared care follow-up initiative, with alternating physician visits and nurse-led telephone consultations and assessments based on patient-reported outcome (PRO) data. Methods Patients ≥18 years diagnosed with B-cell neoplasms were eligible for the study when they were in remission and stable without treatment for at least 6 months. Patients were assigned to alternating visits with physicians and nurse-led telephone consultations. The nurse-led telephone consultations were based on PROs, which were collected with the European Organization for Research and Treatment of Cancer questionnaire (EORTC-QLQ-C30), the Myeloproliferative Neoplasm – Symptom Assessment Form, and the Hospital Anxiety and Depression Scale. Patients completed questionnaires before every nurse-led consultation. We also applied the Patient Feedback Form to survey patient acceptance of the requirement of questionnaire completion. We applied descriptive statistics, in terms of counts (n) and proportions (%), to describe the study population and all endpoints. Results Between February 2017 and December 2018, 80 patients were enrolled. Adherence, measured as the recruitment rate, was 96% (80/83), and the drop-out rate was 6% (5/80). During the study period, 3/80 (4%) patients relapsed, and 5/80 (6%) patients returned to the standard follow-up, because they required closer medical observation. Relapses were diagnosed based on unscheduled visits requested by patients (n = 2) and patient-reported symptoms reviewed by the nurse (n = 1). The response rate to questionnaires was 98% (335/341). A total of 58/79 (74%) patients completed the Patient Feedback Form; 51/57 (89%) patients reported improved communication with health care professionals; and 50/57 (88%) patients reported improved recollection of symptoms as a result of completing questionnaires. Conclusion Based on patient adherence, a low relapse rate, and positive patient attitudes towards completing questionnaires, we concluded that a shared care follow-up, supported by PROs, was a feasible alternative to the standard follow-up for patients with B-cell disease in remission.

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Quality of life in “chronic” cancer survivors: a meta-analysis

Cited by 173 publications

References 91 publications

Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study

Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study

Rationale and Design of a Telehealth Self-Management, Shared Care Intervention for Post-treatment Survivors of Lung and Colorectal Cancer

Shared care follow-up of patients with B-cell neoplasms based on nurse-led telephone consultations and PRO-data: a feasibility study from the North Denmark Region

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