Quality of life in patients with acquired pigmentation: An observational study

Yadav, Anuja; Garg, Taru; Mandal, Ashish Kumar; Chander, Ram

doi:10.1111/jocd.12686

Cited by 21 publications

(26 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ashy dermatosis (AD) and lichen planus pigmentosus (LPP) are both macular pigmentation of uncertain aetiology, predominantly found in patients with skin phototypes III-IV [1]. Despite being asymptomatic, the hyperpigmentation can still cause significant distress to the patients and compromise their quality of life [2]. AD typically presents with insidious ill-defined bilateral slate-grey patches along the skin cleavage lines on the trunk, proximal extremities, and face [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Ashy Dermatosis and Lichen Planus Pigmentosus: The Histopathological Differences

Rutnin

Udompanich

Pratumchart

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Background Ashy dermatosis (AD) and lichen planus pigmentosus (LPP) are both acquired macular pigmentation of uncertain aetiology. Despite the controversy surrounding their entities, recent global consensus has concluded that they are 2 different diseases with distinct clinical presentations. Nevertheless, there are limited data on their histopathological comparisons. Objective To evaluate the differences in histopathological findings between AD and LPP. Methods Electronic records and photographs of patients with the diagnosis of AD or LPP from January 2008 to December 2018 were retrospectively reviewed by a dermatologist. Patients were then classified into groups with AD and LPP, based on the clinical descriptions from the recent consensus. Those with history/clinical presentations suggestive of other causes of macular pigmentation were excluded. The histopathological diagnosis of AD and LPP was then reevaluated by a blinded dermatopathologist. Results One hundred and twenty-four patients with acquired macular pigmentation were identified; 24 were excluded due to clinical history or photographs being inconsistent with AD or LPP. Of the remaining 100 patients, 71 had clinical findings consistent with LPP while 29 had AD. The prevalence of epidermal hyperkeratosis was significantly higher in LPP when compared to AD (33.8% vs. 0%, p < 0.001), as well as epidermal hypergranulosis (35.2% vs. 0%, p < 0.001), lichenoid dermatitis (49.3% vs. 7.1%, p < 0.001), perifollicular infiltration (47.9% vs.10.3%, p < 0.001), and perifollicular fibrosis (35.2% vs. 10.3%, p=0.01). In addition, the degree of pigmentary incontinence was more severe in LPP (21.1% vs. 3.5%, p=0.015). For AD, vacuolization of the epidermal basal cell layer was more common (96.4% vs. 77.5%, p=0.02). Conclusions Although most cases of AD and LPP can be diagnosed clinically, in doubtful cases, histopathological findings of lichenoid dermatitis, epidermal hyperkeratosis/hypergranulosis, and moderate to severe pigmentary incontinence can help distinguish LPP from AD.

show abstract

Section: Introductionmentioning

confidence: 99%

Ashy Dermatosis and Lichen Planus Pigmentosus: The Histopathological Differences

Rutnin

Udompanich

Pratumchart

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…MA is one of the most common diseases in the Middle East (Black and Maibach, ; Rasi, Khatami et al, ). Pigmentation and itching are the reasons for most of the patients' referral to a dermatologist (Yadav, Garg et al, ). In this study, we evaluated the etiological factors in patients as well as histopathology of the skin specimen based on hematoxylin–eosin (H&E), CV, and CR staining.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological evaluation of patients with rippled pattern pigmentation of the skin: A single‐center study

Jowkar

Kahnooj

Aslani

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

The aim of the present study was to investigate the clinical association between rippled pattern pigmentation and the positivity of histopathological analysis for amyloid. A total of 50 patients (90% women) with rippled pattern pigmentation referring to Dermatology Clinic of Shahid Faghihi Hospital, Shiraz, Iran, in 2015 participated in this study. Two biopsies were performed for all the cases from the most frequently affected sites. The specimens were evaluated for amyloid deposits with hematoxylin–eosin (H&E), Congo red (CR), and crystal violet (CV) stains. The upper back was the most frequently affected area in the patients. Family history (28%), atopy (14%), pruritus as a common finding (86%), and history of friction (54%) were positive. The prevalence of disease was higher in patients with skin photo Type 3. Amyloid deposit was not detected in most patients by these stains. No statistically significant difference was found between the amyloid positive cases stained with H&E, CR, and CV (p‐value > 0.05). Only the difference in positive results between biopsy number 2 and the total biopsy (1 and 2) was significant (p‐value < .05). In conclusion, it seems that it is useful to increase the number of biopsies and other more sensitive staining methods to detect small focal amyloid deposits.

show abstract

“…Pigmentary disorders can be divided into acquired, congenital, hypopigmentary, hyperpigmentary, or mixed disorders. Pigmentary disorders have a well‐demonstrated impact on patient quality of life, and as a result, they are a common cause for seeking dermatologic care 1‐3 . Melasma is a chronic, acquired pigmentary disorder that presents with hypermelanosis of sun‐exposed areas of skin.…”

Section: Introductionmentioning

confidence: 99%

“…Pigmentary disorders have a well-demonstrated impact on patient quality of life, and as a result, they are a common cause for seeking dermatologic care. [1][2][3] Melasma is a chronic, acquired pigmentary disorder that presents with hypermelanosis of sunexposed areas of skin. Female predominance has been demonstrated in various studies, and this disorder, also known as the "mask of pregnancy," often plagues gravid women.…”

Section: Introductionmentioning

confidence: 99%

Treatment of melasma: a review of less commonly used antioxidants

Babbush

Khachemoune

2020

Int J Dermatology

View full text Add to dashboard Cite

Melasma, a common cause for seeking dermatologic care, is a chronic condition of skin hyperpigmentation. With a poorly understood pathogenesis, and no universal cure, melasma is a challenge for many dermatologists. For decades, there has been investigation into the role of oxidative stress in melasma. In this literature review, we introduce the role of oxidative stress in melasma and discuss the function of various topical and oral antioxidant therapies for patients suffering from melasma. Numerous studies have shown efficacy of various antioxidant therapies for treatment of hyperpigmentation, and in this review, we focus primarily on those with less widespread use. Vitamin E, niacinamide, polypodium leucotomos, pycnogenol, grape seed extract, amino fruit acids, phytic acid, zinc, silymarin, Korean red ginseng powder, plant extracts, and parsley all have well‐demonstrated evidence of antioxidant properties, and these substances have been studied in the context of skin hyperpigmentation. Although there is conflicting evidence of their therapeutic efficacy, the use of these naturally occurring substances is promising for patients and medical providers seeking alternative therapeutic options.

show abstract

Quality of life in patients with acquired pigmentation: An observational study

Cited by 21 publications

References 4 publications

Ashy Dermatosis and Lichen Planus Pigmentosus: The Histopathological Differences

Ashy Dermatosis and Lichen Planus Pigmentosus: The Histopathological Differences

Clinicopathological evaluation of patients with rippled pattern pigmentation of the skin: A single‐center study

Treatment of melasma: a review of less commonly used antioxidants

Contact Info

Product

Resources

About