Quality of life in patients with Cystic Fibrosis: Association with anxiety and depression

Havermans, T.; Colpaert, K.; Dupont, Lieven

doi:10.1016/j.jcf.2008.05.010

Cited by 105 publications

(89 citation statements)

References 24 publications

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“…(6,19,25) Pulmonary impairment has been described in the literature as an important factor for the onset of emotional stress in individuals with CF, since it correlates with higher morbidity and mortality, requiring treatments that are even more demanding. (21,25) Our results show that children ≥ 6 and < 14 years of age have a satisfactory QoL, regardless of FEV 1 . In contrast, adolescents and adults with greater pulmonary impairment had worse scores in the respiratory, social role, body image, and physical domains.…”

Section: Discussionmentioning

confidence: 60%

“…(13,19) Symptoms of anxiety and depression in adolescents and adults correlate with low scores on instruments designed to quantify QoL and have been described as risk factors for poor treatment compliance, increased morbidity, and increased health care use in chronic diseases. (19,21) Among the parents of the children with CF who participated in this study, lower scores were observed only for the weight domain, suggesting domain than did other patients (86.1 ± 19.5 vs. 50.0 ± 33.3; p = 0.023) and the respiratory domain (88.2 ± 8.6 vs. 65.3 ± 8.3; p = 0.005).…”

Section: Resultsmentioning

confidence: 77%

“…(29) In a recent study involving the use of the CFQ, adults with CF and with altered FEV 1 were found to have lower scores in the domains related to physical functioning and health, indicating that anxiety, depression, and pulmonary function correlate with self-reported QoL. (4,21) Most studies suggest that self-perceived health is directly related to age and to respiratory system impairment, becoming more evident in adolescents and adults with greater lung injury, (4,21,26) as observed in the present study. The assessment of QoL in individuals with CF is important because it reveals the patient perception of what it is like to live with a fatal chronic illness and can improve treatment compliance.…”

Section: Discussionmentioning

confidence: 99%

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Avaliação da qualidade de vida de pacientes com fibrose cística por meio do Cystic Fibrosis Questionnaire

Cohen

Ribeiro

et al. 2011

J. bras. pneumol.

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Objective: To assess the quality of life (QoL) of patients with cystic fibrosis (CF) followed at a university referral center for CF. Methods: A cross-sectional study involving application of the Cystic Fibrosis Questionnaire (CFQ) and Shwachman score in CF patients between April of 2008 and June of 2009. Results: The sample consisted of 75 patients. The mean age was 12.5 ± 5.1 years (range, 6.1-26.4 years). The patients were divided into three groups by age in years: group I (< 12), , and III (≥ 14). The highest and lowest CFQ scores were for the nutrition domain in group III (89.3 ± 16.2) and the social domain in group II (59.5 ± 22.3), respectively. Groups I and III differed significantly regarding the treatment domain (p = 0.001). Regarding Shwachman scores, there were significant differences between patients scoring ≤ 70 and those scoring > 70 in the social (group I; p = 0.045), respiratory (group II; p = 0.053), and digestive (p = 0.042) domains. In group III, severity did not correlate with QoL. In groups I and II, patients with an FEV 1 < 80% of predicted did not differ from other patients for any CFQ domain. However, in group III, values for the following domains were significantly lower in patients with an Resultados:Participaram 75 pacientes, com média de idade de 12,5 ± 5,1 anos (variação: 6,1-26,4 anos). Os pacientes foram divididos em três grupos de acordo com a idade: grupo I (< 12 anos), II (12-14 anos) e III (≥ 14 anos). As pontuações mais altas e mais baixas no CFQ foram para o domínio alimentação do grupo III (89,3 ± 16,2) e para o domínio social no grupo II (59,5 ± 22,3), respectivamente. Houve uma diferença significativa no domínio tratamento entre os grupos III e I (p = 0,001). Pacientes com escore de Shwachman ≤ 70 apresentaram diferenças significativas em relação aos domínios social (grupo I; p = 0,045), respiratório (grupo II; p = 0,053) e digestivo (p = 0,042) quando comparados aqueles com escores > 70. No grupo III, não se observou associação entre gravidade e QV. Nos grupos I e II, não se observou diferenças entre os pacientes com VEF 1 < 80% do previsto e os demais pacientes em todos os domínios do CFQ. Entretanto, no grupo III, as médias dos pacientes com VEF 1 < 80% do previsto foram significativamente menores nos domínios físico (p = 0,012), imagem corporal (p = 0,031), respiratório (p = 0,023), emocional (p = 0,041) e papel social (p = 0,024). Conclusões: A avaliação da QV em pacientes com FC é importante, pois contribui para uma melhor aderência ao tratamento.Descritores: Fibrose cística; Qualidade de vida; Questionários.

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Section: Discussionmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Avaliação da qualidade de vida de pacientes com fibrose cística por meio do Cystic Fibrosis Questionnaire

Cohen

Ribeiro

et al. 2011

J. bras. pneumol.

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“…Several studies have described psychological problems in patients with CF21 but only three, to our knowledge, have explored the relationship with HRQoL (4,5,22). Szyndler et al (22) found that Australian adolescents with CF exhibited psychopathology levels lower than their non-diseased peers (12.5%); however, increased psychopathology was associated with lower ratings on several quality of life scores.…”

Section: Discussionmentioning

confidence: 99%

“…So far, most studies of HRQoL in patients with CF have considered adults (3,4,5) or adults and adolescents6 separately from children (7). Disease severity showed an impact on HRQoL, together with gender in adults and adolescents (females had poorer HRQoL (6).…”

Section: Original Articlementioning

confidence: 99%

Health-Related Quality of Life and Psychological Distress in Italian Patients With Cystic Fibrosis

et al. 2015

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Objective -The aim of this paper is to describe the health related quality of life (HRQoL) in an unselected hospital-based cohort of patients with Cystic fibrosis (CF), and to explore the association between HRQoL and psychological status. Study design -115 patients with CF (47 children, 26 adolescents and 42 adults) attending the Bambino Gesù Pediatric Hospital in Rome, Italy, were recruited. HRQoL was measured through the Cystic Fibrosis Questionnaire (CFQ), child and adult versions. The Youth Self Report Form and the General Health Questionnaire were used to screen for psychological distress in patients aged below and above 18 respectively. Multivariable logistic regression analysis was performed to explore the relationship between CFQ scores and psychological distress, adjusting for socio-demographic and clinical variables. Results -HRQoL was high, except for Social Limitations, Energy/Wellbeing and Treatment Constraints. Twenty-eight patients (24.4%) scored positive for psychological distress. HRQoL scores below median for Symptoms, Body Image and Social Limitations, and unemployment were significantly associated with the presence of psychological distress, while age, screening-based diagnosis, gender and medical factors were not. Conclusions -Screening for psychological distress should be part of routine management of patients with CF. Opportunities for age-appropriate socialization, work and leisure time should be allowed and encouraged.

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Quality of life in rare genetic conditions: A systematic review of the literature

Cohen

Biesecker

2010

American J of Med Genetics Pt A

155

145

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Quality of life (QoL) refers to an individual's sense of overall well-being encompassing physical, psychological, emotional, social, and spiritual dimensions. Although genetics healthcare providers strive to promote patient well-being, and the term QoL is often invoked to refer to this outcome, there is lack of clarity as to what actually constitutes QoL from the patient's perspective. This systematic literature review aims to summarize and integrate research findings to help elucidate how healthcare providers can more effectively enhance the QoL of patients affected with rare genetic conditions. Eligible studies were those that measured QoL as a primary outcome variable using a validated, multi-dimensional scale. Detailed criteria were used to rate quality of design, methodology, and analytic rigor. Fifty-eight studies were selected for inclusion in the review, and a narrative synthesis of the data was performed. A central theme emerging from the literature is that, although genetic conditions have the potential to have significant negative consequences for individuals' lives, having a genetic condition does not necessarily entail poor QoL. Evidence demonstrates that factors beyond the physical manifestations of the disease, such as psychological well -being, coping, and illness perceptions, influence QoL and may serve as potent targets for intervention. The field of research on QoL in rare genetic conditions will be advanced by uniting around a clear conceptualization of QoL and using more rigorous methodology with comprehensive measures of global QoL.†

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Quality of life in patients with Cystic Fibrosis: Association with anxiety and depression

Abstract: Preliminary evidence was found of the role of anxiety and depression in different areas of quality of life in CF, which may help in the development of appropriate medical and psychosocial treatment programs.

Cited by 105 publications

References 24 publications

Avaliação da qualidade de vida de pacientes com fibrose cística por meio do Cystic Fibrosis Questionnaire

Avaliação da qualidade de vida de pacientes com fibrose cística por meio do Cystic Fibrosis Questionnaire

Health-Related Quality of Life and Psychological Distress in Italian Patients With Cystic Fibrosis

Quality of life in rare genetic conditions: A systematic review of the literature

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