Quality of life in patients with primary hyperparathyroidism after surgery

Nikitina, Tatiana; Gladkova, Inna; Rusakov, Vladimir; Chernikov, Roman; Karelina, Yu V; Efremov, Sergey; Ionova, Tatiana

doi:10.14341/probl12825

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…The results obtained are in accordance with our preliminary data analysis [30] and support valuable changes of PROs after surgery. Improvement of QoL after PTX was reported in other studies [6-10, 25] but only in a few of them there were several study time-points after surgery and long-term follow-up was performed.…”

Section: Discussionsupporting

confidence: 90%

Quality of life in patients with primary hyperparathyroidism before and after parathyroidectomy: long term single center experience

Ionova

Buzanakov

Chernikov

et al. 2022

Preprint

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Purpose. Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by a parathyroid tumor or hyperplasia, which is often accompanied with quality of life (QoL) impairment. A parathyroidectomy (PTХ) is the preferred standard treatment for PHPT patients. In this single center study we аimed to evaluate the impact of PHPT оn patient’s QoL and identify QoL changes at early and long-term follow-up after surgery. Methods. All the patients underwent routine PTХ with the removal of the suspected hyperparathyroid gland(s). Patients filled out generic QoL questionnaire RAND SF-36, specific questionnaire PHPQoL and specific symptom assessment questionnaire PAS upon admission to the hospital before surgery, at 3 months, 12 months and 24 months after surgery. Results. A total of 92 patients with PHPT (median age was 56 years, 95.7% females) were included in the study. Before PTХ patient’s QoL was significantly lower as compared to healthy controls (p < 0.01). Almost 40% of patients had poor or very poor QoL. After surgery there was significant improvement in QoL by all scales of SF-36 questionnaire, excluding bodily pain, and the PHPQoL total score (GEE, p < 0.01) as compared with their values before surgery. Decreased mental component of QoL by PHPQoL (OR = 0.927, 95%CI = 0.874–0.984, p = 0.013) predicted improved QoL after surgery. Conclusions. Patients with PHPT demonstrated significantly impaired QoL in physical, psychological and social functioning as well experienced a wide profile of common PHPT symptoms. Successful PTX was accompanied with remarkable QoL improvement and decrease in subjective symptoms for at least 24 months after surgery.

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Section: Discussionsupporting

confidence: 90%

Quality of life in patients with primary hyperparathyroidism before and after parathyroidectomy: long term single center experience

Ionova

Buzanakov

Chernikov

et al. 2022

Preprint

Self Cite

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“…Опросники бывают как общими, так и специфичными для конкретного заболевания. Наиболее часто используются общие анкеты Short Form-36 (SF-36) [8,9], SF-12 [10], WHOQOL-BREF2 [11], EQ-5D [12]. Примерами специфичных для конкретных нозологий опросников могут служить опросники для оценки качества жизни пациентов с глиомами головного мозга (FACT-Br, EuroQol EQ-5D, MOS SF36, EORTC QLQ-C30) [3], респираторная анкета Святого Георгия (Saint George's Respiratory Questionnaire (SGRQ)) [13], опросник 15D для изучения общего HRQoL пациентов, перенёсших эндопротезирование тазобедренного и коленного суставов [14].…”

Section: результатыunclassified

“…EQ-5D -это стандартизированное измерение качества жизни на основе пяти компонентов, связанных со здоровьем, состоящее из вопросника и шкалы остроты зрения. Он был разработан для количественной оценки общих результатов, о которых сообщают пациенты, на основе мобильности, самообслуживания, обычной активности, боли/дискомфорта и тревоги/депрессии [12]. Преимущество данного опросника состоит в том, что Международным обществом по изучению качества жизни разрешено его использование в исследованиях без согласования с разработчиками [19].…”

Section: результатыunclassified

“…Для оценки проявлений заболевания могут использоваться как результаты физикального обследования пациента, так и шкалы симптоматики, специфичные для заболевания опросники [3,6,12,15,21,22].…”

Section: соматическая составляющая качества жизниunclassified

“…Опросник LT-QoL предлагает оценивать различные симптомы пациента в совокупности, обращая внимание не только на типичное проявление болезни, но также на нарушение других систем [23]. Отмечается, что чем больше симптомов и проблем, связанных с заболеванием, испытывает пациент, тем хуже его показатели качества жизни [12], несмотря на это, немалое количество исследований по оценке качества жизни пренебрегает фактором выраженности симптоматики [10].…”

Section: соматическая составляющая качества жизниunclassified

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Objective criteria for the quality of life of patients who underwent surgery (literature review)

Mnoyan,

Zhukov,

Morozov

et al. 2024

vmirvz

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Relevance. One of the tasks of modern surgery is to provide high-quality medical care with a significant impact on the patient, which should lead to an improvement in the quality of life. Quality of life assessment is becoming increasingly relevant in healthcare and is associated with improved decision-making, higher satisfaction and better treatment outcomes.The purpose of the study. To identify criteria for an objective assessment of the quality of life of patients in the postoperative period.Materials and methods. In the course of this study, the most relevant domestic and foreign literary sources were analyzed, reflecting the problem of assessing the quality of life of patients in the postoperative period.Results. To assess the quality of life, various forms of questionnaires for patients are usually used. Questionnaires can be both general and specific for a particular disease. After analyzing numerous questionnaires to determine the quality of life, it became possible to combine and classify objective criteria for the quality of life.Conclusion. The use of general and special questionnaires makes it possible to perform a full-scale assessment of both the main components of the quality of life and its specific aspects in this disease. At the same time, it is important to take into account the influence of various factors, including gender, age, and the initial quality of life, on the change in indicators over time. This approach is the most correct and corresponds to modern recommendations for analyzing quality of life data that changes over time and is associated with various factors.

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Quality of life in patients with primary hyperparathyroidism before and after parathyroidectomy: long term single center experience

et al. 2023

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Background Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by a parathyroid tumor or hyperplasia, which is often accompanied with quality of life (QoL) impairment. A parathyroidectomy (PTX) is the preferred standard treatment for PHPT patients. In this single center study we aimed to evaluate the impact of PHPT on patient’s QoL and identify QoL changes at early and long-term follow-up after surgery. Methods All the patients underwent routine PTX with the removal of the suspected hyperparathyroid gland(s). Patients filled out generic QoL questionnaire RAND SF-36, specific questionnaire PHPQoL and specific symptom assessment questionnaire PAS upon admission to the hospital before surgery, at 3 months, 12 months and 24 months after surgery. Results A total of 92 patients with PHPT (median age was 56 years, 95.7% females) were included in the study. Before PTX patient’s QoL by SF-36 scores was significantly lower as compared to healthy controls (p < 0.01). Almost 40% of patients had poor or very poor QoL. The most frequent symptoms by PAS before surgery were as follows: tiredness (97.8% of patients), weakness (94.6%), forgetfulness (94.6%), mood changes (90%), feeling “blue”/depression (88%), joint pains (83.3%), headaches (80.2%), constant irritability (77.2%), bone pains (75%), thirst (70.7%) and trouble getting out of a chair (67.4%). The half of the patients had moderate-to-severe (≥ 40 scores) tiredness, weakness, joint pains, forgetfulness, as well as mood changes. Post-operative QoL changes were analysed in the group of 72 patients. After surgery there was significant improvement in QoL by all scales of SF-36 questionnaire, excluding bodily pain, and the PHPQoL total score (GEE, p < 0.01) as compared with their values before surgery. Also severity of tiredness, mood changes, weakness and forgetfulness significantly decreased after surgery as compared to their baseline values (GEE, p < 0.05). Decreased mental component of QoL by PHPQoL (OR = 0.927, 95%CI = 0.874–0.984, p = 0.013) predicted improved QoL after surgery. Conclusions Patients with PHPT demonstrated significantly impaired QoL in physical, psychological and social functioning as well experienced a wide profile of common PHPT symptoms. Successful PTX was accompanied with remarkable QoL improvement and decrease in subjective symptoms for at least 24 months after surgery.

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Quality of life in patients with primary hyperparathyroidism after surgery

Cited by 8 publications

References 17 publications

Quality of life in patients with primary hyperparathyroidism before and after parathyroidectomy: long term single center experience

Quality of life in patients with primary hyperparathyroidism before and after parathyroidectomy: long term single center experience

Objective criteria for the quality of life of patients who underwent surgery (literature review)

Quality of life in patients with primary hyperparathyroidism before and after parathyroidectomy: long term single center experience

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