Quality of life in pediatric patients with unremitting constipation pre and post Malone Antegrade Continence Enema (MACE) procedure

Har, Aileen F.; Rescorla, Frederick J.; Croffie, Joseph M.

doi:10.1016/j.jpedsurg.2013.01.045

Cited by 53 publications

(32 citation statements)

References 20 publications

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“…Chronic consumption of alcohol appeared to account for the only candidate with impaired basal and post-treatment GOT and GPT levels. Sacral nerve stimulation and the Malone antegrade continence enema procedure have been shown to be effective in patients with unremitting constipation and defecation disorders, improving QoL [ 23 – 26 ]. However, those are invasive procedures that come with a risk of surgical complications.…”

Section: Discussionmentioning

confidence: 99%

Treatment of irritable bowel syndrome with a novel colonic irrigation system: a pilot study

Hsu

Leung

2016

Tech Coloproctol

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BackgroundMedical treatments for irritable bowel syndrome (IBS) are often disappointing. A colonic irrigation system, the Ashong colonic irrigation apparatus (ACIA), was designed as a patient-administered device for defecation disorders. This pilot study evaluated the efficacy and safety of ACIA for IBS.MethodsEighteen patients, 12 with constipation-dominant IBS (IBS-C) and 6 with diarrhea-dominant IBS (IBS-D) group, were studied. Patients were randomized into treatments of 1–4 weeks. Colonic irrigation was performed twice daily for 6 consecutive days per week. To determine the response to treatment, bowel movement frequency, stool consistency, abdominal pain, patient satisfaction with bowel movements, and distress/discomfort due to symptoms were assessed.ResultsThe scores of abdominal pain (p < 0.001), satisfaction (p < 0.001), and distress/discomfort (p < 0.001) improved significantly. The frequency of bowel movements in the IBS-C group increased from 1.68 to 3.78 times per week (p < 0.001). The occurrence of Bristol Stool Scale type 1 and 2 stool passage decreased from 45 to 13 % (p = 0.009) in the IBS-C group and type 6 and 7 stools decreased from 62 to 28 % (p = 0.005) in the IBS-D group. Only mild adverse events occurred, and all patients completed treatment.ConclusionsColonic irrigation with ACIA is safe and can improve abdominal pain, constipation, and diarrhea associated with IBS. Patients were more satisfied with their bowel movements and found their symptoms were less disturbing. Larger studies on long-term efficacy and quality of life and on placebo effects are needed.

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Section: Discussionmentioning

confidence: 99%

Treatment of irritable bowel syndrome with a novel colonic irrigation system: a pilot study

Hsu

Leung

2016

Tech Coloproctol

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“…It is well accepted that ACE procedures improve quality of life issues and other social parameters reported by patients. Har et al asked patients' parents/guardians to complete the PedsQL(TM) Generic Core Scales QOL survey prior to the operation, 6 months after, and 12 months after the procedure. A total of 15 consecutive patients underwent MACE procedure at a mean age of 9.8 years (range 7.0–11.1 years).…”

Section: Discussionmentioning

confidence: 99%

Left‐colon antegrade enema (LACE): Long‐term experience with the Macedo‐Malone approach

Anselmo

Amaral

Oliveira

et al. 2015

Neurourology and Urodynamics

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“…Redo anorectoplasty can be used to improve the outcome and has been shown in different studies [6]- [8]. However, in cases with severe and resistant constipation or incontinence after an anorectoplasty, and in whom clinical and radiological evaluation reveals a huge and dilated rectum, many pediatric surgeons have been skeptical about the redo anorectoplasty, preferring to use other techniques such as Malone appendicosotmy [9], anterior sagittal anorectoplasty [10], rectosigmoid resection [4] [11], or bowel imbrication [12]. Excision of megarectum in children who had previous repair of anorectal malformation results in fecal continence in the presence of a good internal anal sphincter and absence of neuropathy [13].…”

Section: Discussionmentioning

confidence: 99%

Chronic Constipation and Megarectum in a 14-Year-Old Patient Operated of Anorectal Malformation—Case Report

Statovci¹,

Hyseni²,

Ahmeti³

et al. 2015

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The aim of this paper is to present the case of a female patient, 14 years of age, who developed a megarectum and overflow of fecal incontinence as a consequence of chronic and severe constipation, after the surgical repair of her vestibular fistula at the age one. The huge rectum was resected than dissected down to the pelvic floor and a new anus was reconstructed via a posterior sagittal anorectoplasty with excellent results.

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Quality of life in pediatric patients with unremitting constipation pre and post Malone Antegrade Continence Enema (MACE) procedure

Cited by 53 publications

References 20 publications

Treatment of irritable bowel syndrome with a novel colonic irrigation system: a pilot study

Treatment of irritable bowel syndrome with a novel colonic irrigation system: a pilot study

Left‐colon antegrade enema (LACE): Long‐term experience with the Macedo‐Malone approach

Chronic Constipation and Megarectum in a 14-Year-Old Patient Operated of Anorectal Malformation—Case Report

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