The study investigatedthe forms of indigenous knowledge (IK) and how their utilization determines the quality of life of people in Idemili South Local Government Area of Anambra State, Nigeria. While the main objective of the research wasto investigate how the forms and usage of indigenous knowledge improve the quality of life of people in Nigeria, the specific objectives were: to identify the forms of indigenous knowledge in Nigeria, examine the use of indigenous knowledge in Nigeria and determine the quality of life of rural people in Nigeria. Adopting a survey research design, a multi-stage sampling technique was used to select 287 rural dwellers whose age range was between 20-65years from seven (7) communities as respondents for the study. The questionnaire hadthree sections A-C. The questions were tested for validity and reliability using the Cronbach‟s alpha test. One of the major findings was that appropriate use of the identified forms of IK significantly improve the quality of life of rural people. The study recommended, among others, that libraries and librarians should endeavor to preserve and disseminate IK in Nigeria in order to rekindle interests in indigenous knowledge as a research domain intended to improve the quality of life of the rural people.