Quality of life in type 2 diabetics with gastroesophageal reflux disease: a case control study

Promberger, Regina; Spitzer, Alan R.; Ott, Johannes; Lenglinger, Johannes; Eilenberg, Wolf; Gadenstätter, Michael; Neumayer, Christoph

doi:10.1007/s10353-013-0219-7

Cited by 6 publications

(12 citation statements)

References 47 publications

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“…Similar results have been published earlier [19,39]. Likewise, GERD-specific quality of life was comparable in diabetic and non-diabetic patients although there were some minor differences in health related quality of life [40]. All in all, data on the prevalence of reflux symptoms vary widely within T2D patients, ranging from 25.3% to 45.0% [3,39].…”

Section: Discussionsupporting

confidence: 83%

Gastro-oesophageal reflux disease in type 2 diabetics: symptom load and pathophysiologic aspects - a retro-pro study

et al. 2013

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BackgroundInformation about gastro-oesophageal reflux disease (GERD) in patients with Diabetes mellitus type 2 (T2D) is scarce, although the incidence of both disorders is increasing.We aimed to determine GERD symptoms and their underlying pathophysiologic characteristics in T2D patients.MethodsThis “retro-pro” study compared 65 T2D patients to a control group of 130 age- and sex-matched non-diabetics. GERD was confirmed by gastroscopy, manometry, pH-metry and barium swallow.ResultsIn patients with T2D compared to controls, dysphagia (32.3% vs. 13.1%; p = 0.001) and globus sensation (27.7% vs. 13.8%; p = 0.021) were found more frequently, whereas heartburn (76.9% vs. 88.5%; p = 0.046) and regurgitation (47.7% vs. 72.3%; p = 0.001) were predominant in non-diabetics. Despite higher body mass indices (31.1 ± 5.2 vs. 27.7 ± 3.7 kg/m2; p < 0.001), hiatal hernia was less frequent in T2D patients compared to controls (60.0% vs. 90.8%, p < 0.001). Lower oesophageal sphincter (LES) pressure was higher in patients with T2D (median 10.0 vs. 7.2 mmHg, p = 0.016). DeMeester scores did not differ between the groups. Helicobacter pylori infections were more common in T2D patients (26.2% vs. 7.7%, p = 0.001). Barrett metaplasia (21.5% vs. 17.7%), as well as low- (10.8% vs. 3.8%) and high-grade dysplasia (1.5% vs. 0%) were predominant in T2D patients.ConclusionsT2D patients exhibit different GERD symptoms, higher LES pressures and a decreased prevalence of hiatal hernia than non-diabetics, which may be related to worse oesophageal motility and, thus, a more functional rather than anatomical cause of GERD. Low-grade dysplasia was more than twice as high in T2D than in non-diabetics patients.Trial registrationEthics committee of the Medical University of Vienna, IRB number 720/2011.

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Section: Discussionsupporting

confidence: 83%

Gastro-oesophageal reflux disease in type 2 diabetics: symptom load and pathophysiologic aspects - a retro-pro study

et al. 2013

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“…Studies have found patients with GERD have a decreased health‐related quality of life (HRQoL) compared with the general population. Successfully treating GERD results in an improvement in HRQoL, whereas GERD decreases HRQoL in T2DM …”

Section: Epidemiology Of Gerd In Diabetesmentioning

confidence: 99%

“…Obesity, defined as a BMI >30 kg/m 2 , can decrease life expectancy and increase the risk of developing diabetes mellitus and GERD . The World Health Organization predicted that the world population would comprise of at least 400 million overweight and 700 million obese adults in 2015 .…”

Section: Metabolic Syndrome and Obesitymentioning

confidence: 99%

“…Successfully treating GERD results in an improvement in HRQoL, 15,16 whereas GERD decreases HRQoL in T2DM. 17,18 Although GERD is common in patients with T2DM, there have not been many studies investigating the sequelae of GERD, such as Barrett's esophagus (BE), cough, and sinusitis, to be more common in patients with T2DM. Iyer et al 19 conducted a population-based casecontrol study using a UK database with over 84 000 subjects and concluded that T2DM was a risk factor (for BE).…”

Section: Epidemiology Of Gerd In Diabetesmentioning

confidence: 99%

“…mellitus and GERD. 18,51,52 The World Health Organization predicted that the world population would comprise of at least 400 million overweight and 700 million obese adults in 2015. 53 The IDF defines metabolic syndrome as central obesity combined with two of four additional factors (raised triglycerides, reduced high-density lipoprotein cholesterol, raised blood pressure, and raised fasting plasma glucose).…”

Section: Metabolic Syndrome and Obesitymentioning

confidence: 99%

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Review of gastroesophageal reflux disease (GERD) in the diabetic patient

Punjabi

Hira

Prasad

et al. 2015

Journal of Diabetes

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This article reviews the known pathophysiological mechanisms of comorbid gastroesophageal reflux disease (GERD) in the diabetic patient, discusses therapeutic options in care, and provides an approach to its evaluation and management. We searched for review articles published in the past 10 years through a PubMed search using the filters diabetes mellitus, GERD, pathophysiology, and management. The search only yielded a handful of articles, so we independently included relevant studies from these review articles along with related citations as suggested by PubMed. We found diabetic patients are more prone to developing GERD and may present with atypical manifestations. A number of mechanisms have been proposed to elucidate the connection between these two diseases. Studies involving treatment options for comorbid disease suggest conflicting drug-drug interactions. Currently, there are no published guidelines specifically for the evaluation and management of GERD in the diabetic patient. Although there are several proposed mechanisms for the higher prevalence of GERD in the diabetic patient, this complex interrelationship requires further research. Understanding the pathophysiology will help direct diagnostic evaluation. In our review, we propose a management algorithm for GERD in the diabetic patient.

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