Quality of life in young men after radical prostatectomy

Wright, Jonathan L.; Lin, Daniel W.; Cowan, Janet E.; Carroll, Peter R.; Litwin, Mark S.

doi:10.1038/sj.pcan.4500980

Cited by 27 publications

(20 citation statements)

References 24 publications

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“…Those who took PDE-5 inhibitors may have been more motivated to maintain their baseline sexual function. This is consistent with other reports in which baseline sexual function and the use of sexual aids correlated with worsening sexual concern after RP [77]. Conversely, Japanese men who did not take PDE-5 inhibitors may have viewed ED as a natural part of aging and a normal side effect of cancer treatment.…”

Section: The Effect Of Sexual Qol On Pde-5 Inhibitors After Radical Psupporting

confidence: 82%

Sexual quality of life for localized prostate cancer: a cross‐cultural study between Japanese and American men

Namiki

Arai

2011

Reprod Medicine & Biology

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Introduction Race and ethnicity are important factors in health-related quality of life (QOL) because of racial differences in preferences for, and trust in, health systems. Such factors are likely to affect QOL and patient satisfaction with care. Results Using a self-reported questionnaire, Japanese men with prostate cancer reported lower sexual function scores at baseline. In detail, Japanese men were more likely than American men to report poor sexual desire, poor erection ability, poor overall ability to function sexually, poor ability to attain orgasm, poor quality of erections, infrequency of erections, infrequency of morning erections, and intercourse in the previous 4 weeks. However, Japanese men were less likely than American men to be concerned about their sexual function. Two years after surgery, American patients were more likely than Japanese patients to regain their baseline sexual function. The use of phosphodiesterase-5 (PDE-5) inhibitors has been widely publicized as the solution to erectile dysfunction after prostate cancer treatment. Although PDE-5 inhibitors have been available in Japan since 1999, it is striking that Japanese men with localized prostate cancer are much less likely (only 10%) to use PDE-5 inhibitors than American men. Conclusion Japanese patients with localized prostate cancer report worse sexual function but are less concerned about their reduced function. In the absence of a biological explanation for such differences, however, we suspect that cultural differences may explain the differences between QOL survey results from Japanese or American men with prostate cancer.

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Section: The Effect Of Sexual Qol On Pde-5 Inhibitors After Radical Psupporting

confidence: 82%

Sexual quality of life for localized prostate cancer: a cross‐cultural study between Japanese and American men

Namiki

Arai

2011

Reprod Medicine & Biology

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“…4 Moreover, several authors have reported that the return of serum testosterone level (T) to normal range during intermittent androgen deprivation is associated with a significant improvement of general well-being, and urinary (UF) and sexual function (SF). [5][6][7] In particular, QOL benefits in the off-treatment phase are shown by a shift toward baseline levels in the scales depicting physical and work functions, urgency, nocturia, impotence and sexual performance.…”

Section: Introductionmentioning

confidence: 99%

Influence of serum testosterone on urinary continence and sexual activity in patients undergoing radical prostatectomy for clinically localized prostate cancer

Gacci

Corona

Apolone

et al. 2010

Prostate Cancer Prostatic Dis

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The aim of the present study was to evaluate how serum testosterone level (T) can affect urinary continence and erectile function in patients undergoing radical prostatectomy (RP). We included 257 patients with clinically localized prostate cancer, those who had filled out preoperative quality of life questionnaires (University of California, Los Angeles Prostate Cancer Index, International Index of Erectile Function (IIEF)), and those who had T and total PSA sampled the day before surgery. We calculated correlations between T and age, body mass index (BMI), PSA, urinary function or bother (UF, UB) and sexual function or bother (SF, SB) and IIEF-5 in the whole population and in sub-populations with normal (X10.4 nmol l À1 ) and low (o10.4 ng ml À1 ) T using Pearson's and Spearman's correlation coefficients. We evaluated differences in these parameters between patients with low and normal T using the unpaired samples t-test and Mann-Whitney test, and finally the correlation between UF and SF, UB and SB, and between PSA and T in the overall population, and separately in patients with low and normal T using the Pearson's correlation coefficient. Mean preoperative T was 13.5 nmol l À1 and 23.7% of patients presented a low T. Mean age, mean BMI and mean preoperative total PSA at RP were 64.3 years, 25.9 kg m À2 and 9.0 ng ml À1 , respectively. BMI was negatively correlated with T in the overall population (r ¼ À0.266; P ¼ 0.02); moreover, patients with normal T presented lower BMI compared with patients with low T (25.7 vs 27.6: P ¼ 0.02). We found a significant correlation between SF scores and T in patients with normal T (r ¼ 0.1777: P ¼ 0.05). SF was significantly higher in patients with normal T compared with those with low T (74.8 vs 64.8: P ¼ 0.05). Furthermore, UF and UB were significantly correlated with SF (r ¼ 0.2544: Po0.01) and SB (r ¼ 0.2512: P ¼ 0.01), respectively, in men with normal T. Serum T was significantly correlated with PSA in men with low T (r ¼ 0.3874: P ¼ 0.0029), whereas this correlation was missed in the whole population and in men with normal T. The correlation between preoperative PSA and T in men with low T is in agreement with the 'saturation' model proposed by Morgentaler. The correlation between basal T and preoperative erectile function and urinary continence underlines the importance of assessing T before RP.

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“…3,[7][8][9] Many patients continue to experience symptoms 1-2 years later. 1,3,4,6,7,10,11 Pain, fatigue, and physical and social function are also affected. 1,3,7,8,10 Most studies measured quality of life using psychometric instruments.…”

Section: Introductionmentioning

confidence: 99%

Utility and health-related quality of life in prostate cancer patients 12 months after radical prostatectomy or radiation therapy

Krahn

Bremner

Tomlinson

et al. 2009

Prostate Cancer Prostatic Dis

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This study aims to examine and compare changes in quality of life after two common treatments for prostate cancer (PC), radical prostatectomy (RP) and radiation therapy (RT). Patients newly diagnosed with localized PC, scheduled to receive RP (n ¼ 68) or RT (n ¼ 66), completed three cancer/PC-specific psychometric instruments and three PC-specific utility instruments before treatment, and 2 and 12 months after treatment. We assessed the magnitude and time course of changes in psychometric and utility measures, and differences between treatments. The results showed that RP was associated with significant urinary and sexual dysfunction; RT caused bowel problems. Fatigue and pain were common to both. RP patients reported more problems with physical, role and social function. Utilities decreased significantly after both treatments. Effects were most severe 2 months post treatment, and then showed some recovery, but many endured for 1 year. After 1 year, 30-60% of patients had utility scores that were clinically significantly worse than at baseline. Secondary androgen deprivation therapy also significantly decreased psychometric and utility measures of quality of life. Many adverse symptoms reported 2 months after RP and RT endure for 1 year. Despite different symptom profiles, RP and RT result in similar utility decrements.

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Quality of life in young men after radical prostatectomy

Cited by 27 publications

References 24 publications

Sexual quality of life for localized prostate cancer: a cross‐cultural study between Japanese and American men

Sexual quality of life for localized prostate cancer: a cross‐cultural study between Japanese and American men

Influence of serum testosterone on urinary continence and sexual activity in patients undergoing radical prostatectomy for clinically localized prostate cancer

Utility and health-related quality of life in prostate cancer patients 12 months after radical prostatectomy or radiation therapy

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