Quality of life indices and psychoemotional status of the patients presenting with diffuse toxic goiter during the long-term follow-up after iodine radiotherapy

Древаль, А. В.; Nechaeva, Olga; Гарбузов, П. И.; Mamedova, T.; Chikh, Irina; Krylov, Vladimir

doi:10.14341/probl201359313-18

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…The issues of life quality at the remote stages of anticancer treatment do not lose their relevance [2,3]. The special treatment program for thyroid cancer involves the sequential use of surgical treatment, radionuclide therapy (RNT), and hormone therapy.…”

Section: Introductionmentioning

confidence: 99%

Development of Remote Sequelae Such as Gastrointestinal Tract Pathology in Patients Specially Treated for Differentiated Thyroid Cancer

Radzishevska¹,

Savchenko²,

Radzishevska³

et al. 2021

Novosti Khirurgii

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Objective. Evaluate the potential long-term effects of differentiated thyroid cancer (DTC) treatment, on the gastro-intestinal tract (GIT) based on a retrospective study of DTC patients. Methods. Occurrence of long-term GIT pathologies was retrospectively studied in 157 DTC patients. All patients were treated according to the standard of care, which includes radical surgery, radiation therapy and hormone therapy. The database contained digitalised medical histories of patients followed for at least 1 year after treatment. A total of 463 entries were available, representing one entry per noted consequence for each of the 157 patients. The study focused on two aspects. The frequencies of complications before and after treatment were compared, and factors impacting DTC pathology in a statistically significant manner were isolated. Results: The total onset frequency of gallbladder, liver and pancreas disorders was increased by a factor of 1.6 in a statistically significant manner in DTC patients. Patients initially presenting gallbladder disorders received shorter cures of hormone therapy (4 versus 13 months), and lower levels of L-thyroxine in a context of uncompensated hypothyroidism (2.3 versus 3.5 mg/kg). A statistically significant relation was established between the total duration of breastfeeding in women presenting metabolic health disorders, and onset of liver pathology (essentially non-alcoholic steatohepatitis). Conclusion. Life-long GIT pathology monitoring should be standard of care for patients after special DTC treatment. What this paper adds The long-term effects of treatment of differentiated thyroid cancer on the gastro-intestinal tract have never been described to date. Here, a 1.6-fold increase in disorders implicating mainly the gallbladder, liver and pancreas is noted. Gallbladder disorders are shown to be frequent in patients undergoing short courses of thyroid hormone suppression therapy with low levels of L-thyroxine and presenting uncompensated hypothyroidism. In women presenting metabolic disorders, a relation has been established between the total duration of breastfeeding and the later development of liver pathologies.

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Section: Introductionmentioning

confidence: 99%

Development of Remote Sequelae Such as Gastrointestinal Tract Pathology in Patients Specially Treated for Differentiated Thyroid Cancer

Radzishevska¹,

Savchenko²,

Radzishevska³

et al. 2021

Novosti Khirurgii

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State of intestinal microbiocenosis and quality of life in patients with thyroid diseases

Raevsky¹,

Solov’ev²

2022

Russian Military Medical Academy Reports

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BACKGROUND: Non-invasive methods for diagnosing thyroid pathology with an inapparent, asymptomatic or clinically non-specific course is an urgent task of thyroidology today. It seems promising for such diagnostics to use a combination of mass spectrometry of microbial markers of the human intestinal microbiota with an assessment of the quality of life using the 36-Item Short Form Survey (SF-36) questionnaire. AIM: to study the features of intestinal microbiocenosis and subjective assessment of the quality of life in patients with thyroid diseases. MATERIALS AND METHODS: 21 patients were examined (8 men and 13 women, median age 40,5 [31,75; 54] years, respectively; 15 with thyroid disease of varying degrees of clinical manifestations, 6 without thyroid disease). In addition to the standard clinical and laboratory-instrumental examination, the patients underwent a study of the contents of the large intestine by the method of chromato-mass spectrometry of microbial markers. Through the use of the SF-36 methodology, an assessment of the quality of life was implemented. Descriptive, nonparametric statistics were used in the work, differences in relative frequency values were determined using Fishers exact test. The presentation of the results was carried out using range diagrams, compactly depicting a one-dimensional probability distribution, tables. RESULTS: Differences in the composition of the microbiota of the control group and the study group for Alcaligenes spp., Staphylococcus spp. were revealed, a downward trend in the level of Megamonas hypermegale, Peptostreptococcus anaerobius in the main group is determined. A tendency revealing a decrease in the quality of life in the study group compared with the control in terms of social functioning, role emotional functioning was revealed. CONCLUSIONS: Pathology of the thyroid gland is accompanied by deviations in the composition of the fecal microbiota, determined by the method of mass spectrometry of microbial markers. Characteristic features of changes in the intestinal microbiome are a decrease in the level of Alcaligenes spp., Staphylococcus spp., a tendency to decrease in the titers of Megamonas hypermegale, Peptostreptococcus anaerobius. Violation of the endocrine function of the thyroid gland can cause a deterioration in the quality of life, which is manifested by a tendency to reduce social functioning, role-playing emotional functioning.

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Assessing the influence of special treatment of differentiated thyroid cancer on the urinary system long-term effects

Vasyliev¹,

Radzishevska

Savchenko

et al. 2021

УРОЖ

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Background. Differentiated thyroid cancer (DTC) is the most common endocrine tumour. Its prevalence varies from 1.0% to 2.2% of all malignant neoplasms. The standard strategy of special treatment of DTC consists of surgery, radionuclide therapy and hormone therapy being sequentially applied. Theoretically, each component of the treatment process can cause adverse somatic consequences in future, the study of which can help to prevent and correct them. Purpose – to evaluate possible long-term effects of the treatment of differentiated thyroid cancer in the form of the urinary system (US) pathologies on the basis of follow-up data of long-term observation using sophisticated information technologies. Materials and methods. The study was based on follow-up data of 157 individuals who were undergoing combination treatment of DTC at the Institute clinic from 1993 to 2015, received it in full and underwent regular screening examinations after treatment. The database created for the study contained, as much as possible, digitized arrays of follow-up data of paper case-records on the disease and its consequences in patients with a follow-up period exceeding 1 year after special treatment. The number of logical records of long-term consequences in the generated database was 463 units – one record for one type of long-term consequences of each of 157 patients. Statistical processing of data was carried out in two ways: comparing the incidence of US pathologies before treatment and at a long time after special treatment and identifying factors of statistically significant influence on the occurrence of US pathologies among the treatment peculiarities. WizWhy packages (Data Mining category) and the general purpose software package STATISTICA were used to make hypotheses and test them. Results and discussion. The analysis of the available references has shown that there is only a limited number of papers dealing with the US status of DTC patients. However, a comprehensive analysis of the long-term consequences of treatment of DTC patients revealed a statistically significant increase of US disease cases within the period of 3.75 – 4.8 years after special treatment. It was shown that the total number of US pathologies was 2.04 times higher in comparison with US incidence before the oncet of special treatment. These differences did not depend on age: the median for age of patients before treatment was 51 years, after treatment – 50 years. Additionally, it has been found that patients with or without episodes of postoperative hypothyroidism decompensation with a dose of L-thyroxine not exceeding 2.5 μg/kg need special attention due to the occurrence of urolithiasis. The obtained dependences are quite predictable, since, firstly, it is known that thyroid hormones affect kidney development and physiology, and secondly, the major percent of 131I in radioiodine therapy is excreted with the urine and deposited in the bladder, that can result in a radio-induced carcinogenic effect. Conclusions. Special treatment of DTC increases US pathologies more than twice. The term of post-treatment pathologies is 2.5 (3.75 – 4.8) years. Patients who have episodes of postoperative hypothyroidism during hormone therapy with a dose of L-thyroxine not exceeding 2.5 μg / kg represent the high-risk group.

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Quality of life indices and psychoemotional status of the patients presenting with diffuse toxic goiter during the long-term follow-up after iodine radiotherapy

Cited by 3 publications

References 13 publications

Development of Remote Sequelae Such as Gastrointestinal Tract Pathology in Patients Specially Treated for Differentiated Thyroid Cancer

Development of Remote Sequelae Such as Gastrointestinal Tract Pathology in Patients Specially Treated for Differentiated Thyroid Cancer

State of intestinal microbiocenosis and quality of life in patients with thyroid diseases

Assessing the influence of special treatment of differentiated thyroid cancer on the urinary system long-term effects

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