Quality of life of children with idiopathic nephrotic syndrome according to clinical types

Abstract

Idiopathic nephrotic syndrome (INS) is a major manifestation of chronic idiopathic glomerulonephritis and a common disease in children. The cause and pathogenesis of the disease have not been clarified so far. The treatment is usually a long-term process, from a few months to several years, even decades, including the period of hospitalisation, outpatient treatment period and follow-up period after treatment. The INS patients are negatively affected by the disease and its treatment process. The aim of this study is to assess the health-related quality of life (QOL) of children with INS according to clinical types in Haiphong Children's Hospital. Object: Describe some factors related to the QOL of children with INS. Subjects: 71 patients diagnosed with INS, who are being monitored and treated at Haiphong Children's Hospital from 10/2015 to 05/2016. Methods: Prospective studies, descriptive cross-sectional. QOL of the patients is assessed by the PedsQL 4.0 scale; the higher score shows that the lower QOL. Results: The general QOL score of children with INS (21.24±13.91) was higher than normal children (16.98±10.20). Children with steroid-resistant INS have a higher score (31.62±14.32) than children with steroid-dependent (20.57±9.08) and responsive INS (14.58±6.83). The QOL score of children with one of the symptoms Cushing's face, hirsutism or acne are significantly higher than children without the corresponding symptoms. Children who finished their treatment had a lower score (15.47±7.42) than children being treated (21.33±10.23). The average QOL score has a linear correlation with the duration of INS. Conclusion: The general QOL of children with INS substantially declined compared with that of healthy children. The QOL of children with steroid-dependent and resistant INS is lower than that of the children with steroid-responsive type. The QOL of children with one of the symptoms Cushing's face, hirsutism or acne is significantly lower than that of children without the corresponding symptoms. The QOL of children who completed treatment is higher than the group being treated. The longer the duration of treatment, the more the children's QOL declined.

Health-Related Quality of Life in Sudanese Children with Nephrotic Syndrome: A Comparative Cross-Sectional Study

“…These findings were similar to previous reports that also found that the general QoL of children with NS substantially declined compared to that of healthy children. 18,21 The same findings were observed in a study conducted at Soba Teaching Hospital, Sudan, which showed that all scores were significantly lowered in Sudanese children with NS. 19 This study found that the HRQoL of children with NS was not affected by their age group, except there was significant impairment in school performance in older children.…”

“…These findings were similar to previous reports that also found that the general QoL of children with NS substantially declined compared to that of healthy children. 18 , 21 The same findings were observed in a study conducted at Soba Teaching Hospital, Sudan, which showed that all scores were significantly lowered in Sudanese children with NS. 19 …”

“… 24 However, the Haiphong Children’s Hospital study found that the QoL of children with steroid-dependent and resistant INS was lower than children with a steroid-responsive type. 21 Although one study found a similar result to this study’s finding, we think “it’s a weird result” because theoretically, the phenotypes of NS are more relevant to the dose and duration of immunosuppressants. There must be some difference between different phenotypes in HRQoL scores.…”

“…The study of Nguyen et al had a similar result that showed the QoL of children who had completed their treatment was higher than those who had been still treated. 21 …”

First report on health-related quality of life among children with chronic immune thrombocytopenia in Vietnam

“…The HRQoL of children with ITP and their parents were remarkably lower in comparison with the healthy children. 26,27 In Vietnam, research on HRQoL have been paid attention recently, 28,29 however, HRQoL for chronic ITP patients is still lack of in the country. This study aims to evaluate the HRQoL among Vietnamese children with chronic ITP.…”