Quality of life outcomes after primary radiotherapy for squamous cell carcinoma of the base of tongue

Moore, Giselle J.; Parsons, James T.; Mendenhall, William M.

doi:10.1016/s0360-3016(96)00319-7

Cited by 54 publications

(45 citation statements)

References 7 publications

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“…15 In the RT group no significant differences were noted between the two T-stage groups. This result does not confirm those of the University of Florida series, 16 in which patients with higher stage disease had a higher degree of functional deficit. However, beside certain differences between the two series (different RT schedule and limitation of the current study to oropharynx tumors), in the Florida series no statistical comparison was done to substantiate the observed differences.…”

Section: Discussioncontrasting

confidence: 99%

Quality of life in patients with oropharynx carcinomas: Assessment after accelerated radiotherapy with or without chemotherapy versus radical surgery and postoperative radiotherapy

et al. 2003

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Abstract:Background. In oropharyngeal carcinomas, it is assumed that the effectiveness of the different treatment approaches is roughly equivalent, whereas the functional outcome after radical radiotherapy (RT) is superior to that associated with primary surgery. The aim of this study is to assess quality of life (QoL) outcomes of patients after two treatment strategies: radical surgery with postoperative RT and accelerated concomitant boost RT with or without chemotherapy.Methods. Sixty patients who were disease free at least 1 year after treatment of oropharynx carcinoma were studied. Forty had been treated with radical RT (median tumor dose, 69.9 Gy in 5.5 weeks), and 20 had been treated with primary surgery and postoperative monofractionated RT (median dose, 60.2 Gy). Seven of the former patients received chemotherapy concomitantly with, and one before, RT. Functional outcome was assessed by the subjective Performance Status Scale for Head and Neck cancer (PSSHN) and the general QoL by the European Organization for Research and Treatment of Cancer Core QoL questionnaire (EORTC QLQ-C30). The unpaired t test was used to assess for significant differences between means.Results. By use of the PSSHN module, scores were generally higher in the RT group, with a significant difference in the speech subscale (p = .005), a trend for a significant difference for the eating in public subscale (p = .08), and an insignificant difference for the normalcy of diet subscale (p = .25). When analyzed by tumor stage, no significant differences were observed for T1-2 tumors, whereas for patients with T3-4 tumors highly significant differences favoring the RT group became evident for all three subscales. Although no significant differences were observed using the EORTC QLQ C-30 functional scales, patients treated with primary surgery reported significantly more dyspnea (28 vs 12, p = .04) and appetite loss (30 vs 13, p = .05). In patients with T3-4 tumors, trends toward better scores favoring the RT group were observed for physical, role, emotional, and social functions, as well as a significantly better score for pain symptoms.Conclusions. Although for early stages no clear advantage in QoL outcome was noted for the RT group compared with the surgery group, for advanced-stage disease an advantage favoring radical RT seemed apparent. For those patients, if an equivalency between the two treatment strategies could be assumed regarding oncologic results, then nonsurgical treatment should

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Section: Discussioncontrasting

confidence: 99%

Quality of life in patients with oropharynx carcinomas: Assessment after accelerated radiotherapy with or without chemotherapy versus radical surgery and postoperative radiotherapy

et al. 2003

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“…Most patients in the study (25 of 36) had early Tstage lesions (T1 -T2), which may account for a higher mean PSS score, which has been shown to decline with increasing T stage in patients treated with external beam radiation therapy. 31 Actuarial 5-year local control was 85%, and regional disease control was 96%. The rate of distant metastases was 12.5%.…”

Section: Resultsmentioning

confidence: 98%

Disease control, survival, and functional outcome after multimodal treatment for advanced‐stage tongue base cancer

et al. 2004

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“…Harrison et al 66 reported excellent functional and employment status for patients who received radiation treatment for base of the tongue tumors. Moore et al, 67 also observed long-term functional results for patients who were treated with radiation for tumors of the base of the tongue that appeared superior to those of patients who were treated with surgery. Speech intelligibility and return to a normal diet were noted after 5 years.…”

Section: After Radiationmentioning

confidence: 98%

Combined chemotherapy and radiation therapy for head and neck malignancies

Nguyen

Sallah

Karlsson

et al. 2002

Cancer

200

167

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Acute side effects of combined chemotherapy and radiation therapy usually were found to resolve after treatment. Long-term morbidity is substantial because of xerostomia and severe dysphagia. However, preliminary studies suggest that because of organ preservation, patients may achieve a better quality of life after chemoradiation compared with the conventional use of surgery and postoperative radiation.

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Quality of life outcomes after primary radiotherapy for squamous cell carcinoma of the base of tongue

Cited by 54 publications

References 7 publications

Quality of life in patients with oropharynx carcinomas: Assessment after accelerated radiotherapy with or without chemotherapy versus radical surgery and postoperative radiotherapy

Quality of life in patients with oropharynx carcinomas: Assessment after accelerated radiotherapy with or without chemotherapy versus radical surgery and postoperative radiotherapy

Disease control, survival, and functional outcome after multimodal treatment for advanced‐stage tongue base cancer

Combined chemotherapy and radiation therapy for head and neck malignancies

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