Quality of life, patient satisfaction, and disease burden in patients with gastroesophageal reflux disease with or without laryngopharyngeal reflux symptoms

Gong, Eun Jeong; Choi, Kee Don; Jung, Hye Kyung; Youn, Young Hoon; Min, Byung Hoon; Song, Kyung Ho; Huh, Kyu Chan

doi:10.1111/jgh.13716

Cited by 27 publications

(20 citation statements)

References 25 publications

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“…Most importantly, psychological factors are linked to the deterioration of the symptoms of GORD (22). It was also found that quality of life declined depending on the severity of LPR regardless of marital status and household income (23). The high prevalence of smoking may be a factor of the high prevalence of LPR in Syria (9), mainly that there are no strong regulations to prevent smoking, causing a high exposure to second-hand smoking which could not be measured in our study.…”

Section: Discussionmentioning

confidence: 59%

Laryngopharyngeal Reflux Disease in War-torn Syria and its Association with Smoking and other Risks.

Kakaje

Alhalabi

Alyousbashi

et al. 2020

Preprint

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Backgrounds: Syria has entered its ninth year of conflict and as its medical sector facing major hurdles, laryngopharyngeal reflux (LPR) is often overlooked although it has an association with worsening quality of life and affecting many aspects as it is chronic and left untreated although it can lead to many complications such as dysphonia. This study is to evaluate LPR prevalence and its association with different aspects such as cigarette, and shisha smoking, and the effect of war on LPR.Methods: Cross-sectional study by using online questionnaires that included demographics, smoking, war related questions and reflux symptom index (RSI) were used online in many cities around Syria.Findings: This research included 734 responders with 75.5% being female and the mean age being 23.97 years. 31.9% of subjects had symptoms suggestive of LPR. Participants were Syrians and we included every responder who agreed and did not neglect any question. We only found that being distressed from war noises was associated with positive LPR symptoms [P=0.009 (OR, 1.562; 95% CI 1.117-2.183)], but losing someone or changing place of living due to war were not associated with LPR. LPR was associated with cigarette smoking (P<0.05). Finally, having asthma, and male gender in the younger population were associated with LPR (P<0.05). No clear association with age, or shisha and no significant associations were found with consanguinity, marital status, educational level and SES.Interpretations: About one third had LPR symptoms. War distress from war noise, cigarette smoking, asthma, and allergic were significantly correlated with LPR.

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Section: Discussionmentioning

confidence: 59%

Laryngopharyngeal Reflux Disease in War-torn Syria and its Association with Smoking and other Risks.

Kakaje

Alhalabi

Alyousbashi

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…32,33 Moreover, Gong et al observed that the severity of LPR symptoms was related to decreased health-related quality of life. 34 In our correlation analysis, we formally identified positive correlations between SF-36 scorings and the scores of VHI categories. The relationship between these two quality-of-life instruments may suggest that the development of hoarseness, and the related increase of VHI scores (communicative handicap) can alter the overall quality of life of patients.…”

Section: Discussionmentioning

confidence: 98%

Voice Quality as Therapeutic Outcome in Laryngopharyngeal Reflux Disease: A Prospective Cohort Study

et al. 2020

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“…Psychological distress has been studied in the context of LPR in the past. Gong et al . demonstrated that GERD patient with LPR had more depression or anxiety than those without LPR.…”

Section: Discussionmentioning

confidence: 99%

“…Gong et al 13 demonstrated that GERD patient with LPR had more depression or anxiety than those without LPR. In our study, we report that depression is a more important factor than anxiety.…”

Section: Discussionmentioning

confidence: 99%

“…Psychological distress such as depression, anxiety, and sleep disturbance have been implicated in the etiopathogenesis of LPR symptoms . GERD patients with LPR symptoms have been reported to have poor health‐related quality of life and higher depression and anxiety than those without LPR symptoms . Therefore, psychiatric comorbidities may be considered as an important target in the management of LPR symptoms in the context of GERD.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and psychological characteristics in gastroesophageal reflux disease patients overlapping with laryngopharyngeal reflux symptoms

Wong

Bair

Chang

et al. 2019

J of Gastro and Hepatol

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Background and Aim Laryngopharyngeal reflux (LPR) defined as reflux of gastric content reaching above the upper esophageal sphincter is frequently found in patients with gastroesophageal reflux disease (GERD). This study aimed to investigate clinical and psychological differences between GERD patients with or without LPR symptoms. Methods This study enrolled 303 consecutive patients with proton pump inhibitor treatment‐naïve scheduled for upper endoscopy because of troublesome reflux symptoms and recognized as GERD by non‐dyspepsia reflux disease questionnaire score. Included GERD patients were further categorized into two study groups: with or without LPR by reflux symptoms index score. All participants were also evaluated with questionnaires for depression, anxiety, and sleep disturbances. Results There were 132 (43.6%) GERD patients with LPR symptoms and 171 (56.4%) GERD patients without LPR symptoms. GERD patients with LPR symptoms had more depression (P < 0.001), sleep disturbance (P = 0.002), irritable bowel syndrome (P = 0.008), functional dyspepsia (P = 0.005), and reflux symptoms burden (P < 0.001) than those without LPR symptoms. Erosive esophagitis was more in patients without LPR symptoms (P = 0.03). GERD patients with LPR symptoms (28.8%) had more complex psychological distress than those without LPR symptoms (28.8% vs 14%, P < 0.001). Reflux symptoms burden, sleep disturbance, and erosive esophagitis were independently associated with GERD overlapping with LPR symptoms. Conclusions Gastroesophageal reflux disease patients with LPR symptoms appear to have more reflux symptoms, psychological distress, and functional gastrointestinal disturbance but less erosive esophagitis. This work suggests that therapeutic strategy with tailored multidimensional approach is promising for GERD patients overlapping with LPR symptoms.

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Quality of life, patient satisfaction, and disease burden in patients with gastroesophageal reflux disease with or without laryngopharyngeal reflux symptoms

Abstract: Gastroesophageal reflux disease patients with LPR symptoms have a poorer HRQL, a lower satisfaction rate, and a greater disease burden than those without LPR.

Cited by 27 publications

References 25 publications

Laryngopharyngeal Reflux Disease in War-torn Syria and its Association with Smoking and other Risks.

Laryngopharyngeal Reflux Disease in War-torn Syria and its Association with Smoking and other Risks.

Voice Quality as Therapeutic Outcome in Laryngopharyngeal Reflux Disease: A Prospective Cohort Study

Clinical and psychological characteristics in gastroesophageal reflux disease patients overlapping with laryngopharyngeal reflux symptoms

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