Quality of life profile and psychometric properties of the EQ-5D-5L in HIV/AIDS patients

Abstract

ObjectivesWe assessed health-related quality of life (HRQOL), its associated factors, and examined measurement properties of the EuroQol - 5 Dimensions - 5 Levels (EQ-5D-5L) in HIV/AIDS patients.MethodsA cross-sectional multi-site survey was conducted in 1016 patients (age: 35.4 ± 7.0 years; 63.8% male) in three epicenters of Vietnam. Internal consistency reliability, convergent validity, and discriminative validity of the EQ-5D-5L and a visual analogue scale (VAS) were evaluated. Tobit censored regression models were used to identify predictors of HRQOL in HIV/AIDS patients.ResultsThe mean EQ-5D-5L single index and VAS were 0.65 (95% Confidence Interval (CI) = 0.63; 0.67) and 70.3 (95% CI = 69.2; 71.5). Cronbach’s alpha of five dimensions was 0.85. EQ-5D-5L has a good convergent validity with VAS (0.73). It discriminated patients at different HIV/AIDS stages, duration of ART, and CD4 cell count. Predictors of poorer HRQOL included being female, lower education level, unemployment, alcohol and drug use, CD4<200 cells/mL, and advanced HIV/AIDS stages.ConclusionThe EQ-5D-5L has good measurement properties in HIV/AIDS patients and holds potentials for monitoring ART outcomes. Integration of HRQOL measurement using EQ-5D-5L in HIV/AIDS clinical practice could be helpful for economic evaluation of HIV/AIDS interventions.

Qualidade de vida e adesão à medicação antirretroviral em pessoas com HIV

“…(7) The prevalence of male participants in this study corroborates several previous studies. (3,(7)(8)(9) Regarding education, the present study had a significant number of people who had completed high school, different from that found in the literature, which points to lower schooling, with incomplete primary education predominating.…”

Willingness to pay for methadone maintenance treatment in Vietnamese epicentres of injection-drug-driven HIV infection

“…11 Health status in five dimensions (mobility, self-care, usual activities, pain/discomfort and anxiety/ depression) was measured using the five-level EQ-5D (EQ-5D-5L) instrument (EuroQol Group, Rotterdam, Netherlands). 20 Interviewers summarized several aspects of MMT in Viet Nam to ensure that patients had sufficient background knowledge before completing the willingness to pay valuation. Interviewers first reviewed the adverse consequences of injection drug use (e.g.…”

“…A detailed description of the survey design and sampling methods is presented elsewhere. 8,17 Survey participants comprised inpatients and outpatients with HIV infection who were attending ART clinics in three district health centres, three provincial hospitals and one central hospital. All patients visiting the clinics during the study period were invited to complete the survey and provided written informed consent if they agreed to participate.…”

Characterisation of clinical epidemiological profile of patients with facial lipoatrophy, living with AIDS, submitted to facial filling with polymethylmethacrylate

“…These patients also suffer with emotional and psychiatric disorders, which cause a loss of self-esteem, family problems, social exclusion and, worse still, abandonment of treatment that can lead to disease progression [12][13][14].…”