Quality of Life (QoL) in Patients With Benign Thyroid Goiters (Pre‐ and Post‐Thyroidectomy): A Prospective Study

Mishra, Anjali; Mayilvaganan, Sabaretnam; Chand, Gyan; Agarwal, Gaurav; Agarwal, Amit; Verma, Ashok Kumar; Mishra, Saroj Kanta

doi:10.1007/s00268-013-2133-3

Cited by 56 publications

(94 citation statements)

References 35 publications

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“…Another important issue that could modify/influence both surgeon and patient choice in favor of a surgical option is the assessment of the QoL after thyroidectomy. Prior studies indicated that surgery extent does not influence the QoL [38] and the specific symptom Btiredness^remains one of the most affected domains [39][40][41] after thyroidectomy. It should be noted that in these studies both TT and HT are considered together.…”

Section: Discussionmentioning

confidence: 99%

“…One study highlighted the psychological changes rather than appearance or worsening of the tiredness or asthenia [11]. Another study showed the advantages of thyroidectomy in reducing post-operative fatigue by evaluating a cohort of patients with various hormone levels [8]. A recent study [12] reported that TT is frequently accompanied by chronic low-moderate asthenia.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have examined patient quality of life (QoL) related to the thyroid disorders and evaluated this aspect before and after treatment. The majority of studies investigated the correlation between QoL and hormone changes [8][9][10]. One study highlighted the psychological changes rather than appearance or worsening of the tiredness or asthenia [11].…”

Section: Introductionmentioning

confidence: 99%

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The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

Scerrino¹,

Raspanti²,

Attard³

et al. 2017

Langenbecks Arch Surg

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Purpose Chronic asthenia (CA) is complained by some patients that have undergone thyroid surgery. We evaluate its impact in patients undergoing unilateral or bilateral thyroidectomy, the trend during a 1-year follow-up, and the possible risk factors. Methods A prospective, cohort study was carried out on 263 patients scheduled for thyroidectomy from 2012 and 2014. Exclusion criteria were as follows: Graves' disease, malignancies requiring radioiodine therapy, post-surgical hypoparathyroidism, laryngeal nerve palsy, abnormal pre-and postoperative thyroid hormone levels, and BMI outside the normal range. Demographics; smoking and alcoholism addiction; cardiac, pulmonary, renal, and hepatic failure; diabetes; anxiety; and depression were recorded. The Brief Fatigue Inventory (BFI) was used to evaluate CA and its possible association with these comorbidities 6 and 12 months after thyroidectomy. Results One hundred seventy-seven patients underwent total thyroidectomy (TT), 54 hemithyroidectomy (HT). Thirty-two patients were not recorded because of the onset of exclusion criteria. In the 6 months after thyroidectomy, in the TT group, 64 patients (36.16%) reported an impairment in the BFI score and only 1 in the TL group. The mean BFI score changed from 1.663(±1.191) to 2.16 (±11.148) in the TT group, from 1.584 (±1.371) to 1.171 (±1.093) in the TL group (p < 0.001). No further significant variations in BFI were reported 1 year after surgery. Conclusions CA worsened after TT, but not after HT. Apart from operative procedure itself, no other risk factor was found be significantly associated with post-thyroidectomy asthenia. Further investigation is needed to determine the causes of CA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

Scerrino¹,

Raspanti²,

Attard³

et al. 2017

Langenbecks Arch Surg

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“…Fast et al (2014) found that the majority of patients treated with rhTSH for goitre reported an improvement in symptoms on the specific ThyPRO scale concerning goitre, and that the improvement persisted at least up to the 36 th month [19]. Moreover, according to studies conducted by two groups of surgeons on patients who had undergone thyroidectomy for goitre, QoL improved significantly after surgery, whether total thyroidectomy or hemithyroidectomy had been performed [24,25].…”

Section: Discussionmentioning

confidence: 99%

Quality of life in patients treated with radiofrequency ablation for thyroid nodules

Oddo¹,

Felix²,

Repetto³

et al. 2016

Res J Endocrinol Metab

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Background: Many studies have reported mean reductions in nodule volumes and described improvements in the sense of pressure and aesthetic symptoms after radiofrequency ablation. The aim of our study was to document changes in quality of life by means of a 13-scale questionnaire named ThyPRO in a cohort of patients treated with radiofrequency ablation for benign thyroid nodules. Moreover, we assessed the efficacy and safety of the procedure and correlations between efficacy and some features both of the treated nodules and of patients, and evaluated improvements in neck discomfort by means of a visual analogic scale. Methods: 32 patients with benign thyroid nodules were treated with radiofrequency ablation. We evaluated nodule volume, thyroid function and autoimmunity before and after procedures, adverse events during and after procedures, changes in neck discomfort by means of a visual analogic scale and changes in quality of life through the ThyPRO questionnaire at 1, 3, 6 12, 24 and 36 months. We sought correlations between response to radiofrequency ablation and some features of procedures and patients. We divided patients into 2 groups, according to their mean percentage of nodule volume reduction: group 1 (reduction >30%) and group 2 (reduction <30%) to evaluate whether ThyPRO questionnaire scores changed in patients in whom thyroid RFA was more effective. Results: At the last evaluation, nodule volume reduction was 45±9 in group 1, 11±9 in group 2 and 40±25% in the total population. We found a correlation between better volume reduction and greater patient age. Thyroid function and autoimmunity were not modified. Adverse events were few and mild. Visual analogic scale scores improved, though scores on the individual ThyPRO scales did not change, even in group 1. The general subjective impact of thyroid disease on quality of life improved from the 3rd month onwards. Conclusions: In our cohort of patients, quality of life, as evaluated through ThyPRO, did not improve after radiofrequency for benign thyroid nodules. In the literature, changes in quality of life in patients treated with radiofrequency ablation for thyroid nodules have been described in only one paper, while changes in quality of life assessed by means of ThyPRO have never been described.

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“…Понятно, что значительная часть пациентов, страдающих патологией щитовидной железы, нуж-даются в хирургическом лечении, и ввиду большой распространенности данной патологии важнейшей задачей современной хирургии становится улучше-ние качества жизни больных в послеоперационном периоде [5][6][7][8]. Очевидно, что основное внимание в этом вопросе приковано к предотвращению раз-вития таких тяжелых осложнений, как параличи гортани и послеоперационный гипопаратиреоз, ко-торые могут привести к инвалидизации пациента.…”

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On the issue of adhesions after noncomplicated thyroidectomy and application of antiadhesive medications in thyroid surgery

Курганов¹,

Bogdanov²,

Лукьянченко³

et al. 2015

Endosk. khir.

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Quality of Life (QoL) in Patients With Benign Thyroid Goiters (Pre‐ and Post‐Thyroidectomy): A Prospective Study

Abstract: Patients with benign goiters experience significant improvement in QoL after thyroidectomy.

Cited by 56 publications

References 35 publications

The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

Quality of life in patients treated with radiofrequency ablation for thyroid nodules

On the issue of adhesions after noncomplicated thyroidectomy and application of antiadhesive medications in thyroid surgery

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