Background: Breast cancer is a major leading cause of maternal cancer morbidity and mortality, and surgical resection is the standard of therapy for all non-metastatic patients. Aim: This study aimed to assess the expectations and experiences of women undergoing mastectomy regarding nursing care. Design: A descriptive cross sectional study design was utilized. Methods: This study was carried out at Oncology Center at Mansoura University, Dakahlia governorate, Egypt. A convenient sample included 106 women who admitted for mastectomy chosen according to the inclusion criteria. Two tools were used: Tool I: Structured interviewing questionnaire. Tool II: assessment of expectations and experiences of mastectomy women regarding nursing care by using "quality of oncology patients' centered nursing care scale". Results: majority of the studied women had positive expectations about responsiveness and proficiency of nursing care (95.3%&93.4%respectively) while most of the studied women had negative experience about sense of belonging and coordination of nursing care (93.4%&83%respectively) while (84.9%) had positive experience of responsiveness of nursing care. Most of the studied women (85.8%) had positive expectations of overall nursing care while more than half of them (54.7%) had negative experiences of overall nursing care. A statistically significant differences between expectations and experiences regarding nursing care (p < 0.001) Conclusion: The current study questions were answered where majority of the studied women had positive expectations and more than half of them reported negative experiences of nursing care Recommendations: The study recommended large investing in personcentered care and improving in nursing education and training programs about it.