Abstract. This study investigated the influence of management on quality assurance in National Teachers Colleges (NTCs) in Uganda. The study was prompted by the persistent complaints from key stakeholders about the deteriorating quality of teacher trainees from the NTCs. The study used the descriptive cross-sectional sample survey research design where both qualitative and quantitative approaches to data collection and analysis were used to gain an in-depth understanding of the issues that were investigated. Data were collected from 79 lecturers, three principals, six deputy principals, three academic registrars, and two officials from the Uganda's Ministry of Education and Sports. Study respondents were selected through purposive and convenience sampling techniques. Data were analysed through the use of appropriate descriptive and inferential statistics as well as a content analysis technique. Study results revealed that planning (p=.001<.05), controlling (p=.047<.05), and directing (p=.000<.05) have statistically significant influence on quality assurance; meanwhile, organizing (p=.148>.05) has a statistically weak influence on quality assurance in NTCs. The researchers thus concluded that management significantly influences the assurance of quality in NTCs in Uganda, other factors notwithstanding. It was therefore recommended that periodic audits and reviews need to be undertaken by managers of NTCs in order to detect any anomalies regarding quality in their institutions. Besides, the principles of total quality management need to be incorporated in the management of quality at NTCs so as to engage all relevant stakeholders such as students and employees in managing quality at the institutions. Finally, the managers of NTCs are recommended to benchmark and adapt best practices of assuring quality from other institutions of higher education.