Quantification and Preliminary Estimation of Toxic Effects of Polycyclic Aromatic Hydrocarbon in Some Antimalarial Herbal Drugs in Southwest Nigeria

SA, Akintelu; BE, Abiola; Ajayi, SO; OM, Olabemiwo

doi:10.21276/bpr.2018.8.1.1

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…The susceptibility of the fungi strains to synthesized AgNPs was in the order of Candida tropicalis > Aspergillus flaws > Fusarium oxysperium > Candida albican. The antifungal activity of this study was found to be higher than that obtained from the previous studies [46][47][48][49][50][51]. The higher antifungal potency…”

Section: Antifungal Activity Of Synthesized Agnpscontrasting

confidence: 79%

Green Synthesis, Characterization, and Antifungal Activity of Synthesized Silver Nanoparticles (AgNPS) from Garcinia Kola Pulp Extract

2021

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The prevention or cure of microbial infections are mostly combated with the use of antibiotics. However, the activity of most of the available antibiotics had been nullified by fungi resistance. This study was aimed at the investigation of the antifungal property of silver nanoparticles (AgNPs) synthesized from Garcinia kola pulp. The pulp of Garcinia kola were obtained from its ripe fruit, dried and pulverized into fine particles and extracted with water. The extract was mixed with 1mM aqueous silver nitrate following necessary procedure to form AgNPs. The AgNPs synthesized were characterized and screened against tested fungi using standard method. The inhibition zones were measured and recorded after incubation of the plates at a temperature of 35 °C for 24 h. The morphological assessment of the synthesized AgNPs confirmed the variation in particle size ranging from 24 to 10 nm with an average size distribution of 17 nm and a spherical shape. The synthesized AgNPs show good activity against tested fungi strains with inhibition zones ranging from 6 to 17 mm which is comparable to the inhibition zones demonstrated by the control in the range of 18 to 24 mm. This study indorsed the use of AgNPs against fungi infections owning to the antifungal activity displayed against tested fungi strains. Keywords Silver nanoparticles • Garcinia kola pulp • Clinical isolates and fungi activity

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Section: Antifungal Activity Of Synthesized Agnpscontrasting

confidence: 79%

Green Synthesis, Characterization, and Antifungal Activity of Synthesized Silver Nanoparticles (AgNPS) from Garcinia Kola Pulp Extract

2021

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Concentration and sources of polycyclic aromatic hydrocarbons in some commercial herbal drugs used for cholera treatment in southwest Nigeria

et al. 2020

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The aim of this study was to investigate the cancer risk that could be incurred from the use of some anti-cholera herbal drugs sold in Southwest Nigeria. Three most popular anti-cholera herbal drugs were studied. The cancer risk estimation for the drugs at studied population ranges from 7.119 to 0.338 x 10-8 in children, 9.563 to 0.129 x 10-8 in preteen and 9.541 to 5.196 x 10-8 in adult. The cancer risk estimated values are below the USEPA set value 1 x 10-6. This established that the use of these herbal drugs might not lead to cancer if consumed at low dosage.

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Speculative Carcinogenicity Assessment of Polycyclic Aromatic Hydrocarbons Found in Some Anti-Diarrheal Herbal Drugs Sold in Ondo State of Nigeria

Akintelu

Folorunso

2021

eijs

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The conviction that herbal drugs have enormous health benefits has led to increase the rate of their consumption by Nigerians. The aim of this study was to assess the carcinogenic property of some popularly consumed anti-diarrheal herbal drugs via polycyclic aromatic hydrocarbons (PAHs) quantification. Three prevalent anti-diarrhea herbal drugs , Odunmo herbal drug (Hibiscus rosa-sinensis and Bacopamonnieri), Orogun herbal mixture (Hibiscus sabdariffaI and Hedera helix), and Alora herbal syrup (Aloe vera and Hibiscus sabdariffaI) were bought for the purpose of this study and they were coded as samples A, B, and C, respectively. The ultrasonic extraction of the herbal drugs was carried out using standard procedures. The crude extracts obtained were purified using a chromatographic method. The concentrations of PAHs were quantified using gas chromatography flame ionization detector (GCFID). The diagnostic indices, group distribution, toxicity equivalence and exposure dosage were estimated. The cancer risk values were theoretically speculated based on concentrations of PAHs in the tested herbal drugs, associated with the published estimates of each concentration to cause cancer and the calculated exposure doses of the anti-diarrhea herbal drug samples were within three age groups (children, Preteen and adult). The highest concentration of total PAHs was observed in sample A (58.2815mg/kg) and the lowest concentration in sample B (44.1898mg/kg), but the concentration of total PAHs in sample C was 47.4169 mg/kg. The highest percentage of carcinogenic PAHs in the anti-diarrheal herbal drugs was found in sample C (48.66%) and the lowest in sample B (38.17%). The diagnostic indices confirmed a pyrogenic source of PAHs. Group distribution of PAHs showed that the herbal drugs are weakly carcinogenic due to high concentrations of low and moderate molecular weight PAHs. The cancer risk estimated for all the age groups where below the limit established by the United State Environmental Protection Agency (USEPA) for cancer (1 x 10-6). This ascertained that the use of these herbal drugs cannot cause cancer. However, consumers of these herbal drugs should take necessary precautions as excessive intake can lead to dangerous health implications.

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Quantification and Preliminary Estimation of Toxic Effects of Polycyclic Aromatic Hydrocarbon in Some Antimalarial Herbal Drugs in Southwest Nigeria

Cited by 3 publications

References 7 publications

Green Synthesis, Characterization, and Antifungal Activity of Synthesized Silver Nanoparticles (AgNPS) from Garcinia Kola Pulp Extract

Green Synthesis, Characterization, and Antifungal Activity of Synthesized Silver Nanoparticles (AgNPS) from Garcinia Kola Pulp Extract

Concentration and sources of polycyclic aromatic hydrocarbons in some commercial herbal drugs used for cholera treatment in southwest Nigeria

Speculative Carcinogenicity Assessment of Polycyclic Aromatic Hydrocarbons Found in Some Anti-Diarrheal Herbal Drugs Sold in Ondo State of Nigeria

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