Quantification of airway diameters and 3D airway tree rendering from dynamic hyperpolarized <sup>3</sup>He magnetic resonance imaging

Lewis, Tina A.; Tzeng, Yang-Sheng; McKinstry, Erin L.; Tooker, Angela; Hong, Kyong-Soo; Sun, Yanping; Mansour, Joey; Handler, Zachary; Albert, Mitchell S.

doi:10.1002/mrm.20349

Cited by 37 publications

(31 citation statements)

References 20 publications

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“…Current methods for the assessment of these disorders include measures of lung function, radiologic techniques such as CT scanning (1), radionuclear-based ventilation/perfusion lung scans (2)(3)(4)(5), use of hyperpolarized 3-He gas (2,(6)(7)(8) in conjunction with magnetic resonance imaging (MRI), or direct assessment of lung pathology. Much of the focus on mechanisms of improvement has focused on lung mechanics (9)(10)(11). RemyJardin and colleagues (1) have provided a unique observation via CT demonstrating that longitudinal changes leading to an emphysema-like lung begin with micronodular and ground-glass appearances in the lung field correlating to bronchiolitis and parenchymal inflammation.…”

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confidence: 99%

State of the Art. A Structural and Functional Assessment of the Lung via Multidetector-Row Computed Tomography: Phenotyping Chronic Obstructive Pulmonary Disease

Hoffman

Simon²,

McLennan³

2006

Proceedings of the American Thoracic Society

148

137

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With advances in multidetector-row computed tomography (MDCT), it is now possible to image the lung in 10 s or less and accurately extract the lungs, lobes, and airway tree to the fifth-through seventh-generation bronchi and to regionally characterize lung density, texture, ventilation, and perfusion. These methods are now being used to phenotype the lung in health and disease and to gain insights into the etiology of pathologic processes. This article outlines the application of these methodologies with specific emphasis on chronic obstructive pulmonary disease. We demonstrate the use of our methods for assessing regional ventilation and perfusion and demonstrate early data that show, in a sheep model, a regionally intact hypoxic pulmonary vasoconstrictor (HPV) response with an apparent inhibition of HPV regionally in the presence of inflammation. We present the hypothesis that, in subjects with pulmonary emphysema, one major contributing factor leading to parenchymal destruction is the lack of a regional blunting of HPV when the regional hypoxia is related to regional inflammatory events (bronchiolitis or alveolar flooding). If maintaining adequate blood flow to inflamed lung regions is critical to the nondestructive resolution of inflammatory events, the pathologic condition whereby HPV is sustained in regions of inflammation would likely have its greatest effect in the lung apices where blood flow is already reduced in the upright body posture.

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mentioning

confidence: 99%

State of the Art. A Structural and Functional Assessment of the Lung via Multidetector-Row Computed Tomography: Phenotyping Chronic Obstructive Pulmonary Disease

Hoffman

Simon²,

McLennan³

2006

Proceedings of the American Thoracic Society

148

137

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“…Using dynamic hyperpolarised 3 He, LEWIS et al [101] quantified airway diameters of bronchial tree generations 0-5. They compared diameter measurements at each airway generation with the theoretical diameter based on the Weibel lung model.…”

Section: Magnetic Resonance Airway Imagingmentioning

confidence: 99%

“…To improve the applications of MRI imaging, slice thickness will need to be reduced (13 mm in the study by Lewis et al [101]), the effect on measurement accuracy of scanning at various angles will need to be assessed, and the thresholdbased measurement algorithm will require further validation. An ongoing problem remains access to MRI and hyperpolarised gases.…”

Section: Magnetic Resonance Airway Imagingmentioning

confidence: 99%

Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

Williamson¹,

James²,

Phillips³

et al. 2009

Eur Respir J

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The ability to measure airway dimensions is important for clinicians, interventional bronchoscopists and researchers in order to accurately quantify structural abnormalities and track their changes over time or in response to treatment.Most quantitative airway measurements are based on X-ray computed tomography and, more recently, on multidetector computed tomography. Quantitative bronchoscopic techniques have also been developed, although these are less widely employed. Emerging techniques, including magnetic resonance imaging, endoscopic optical coherence tomography, endobronchial ultrasound and confocal endomicroscopy, provide new research tools with potential clinical applications.An understanding of issues related to the acquisition, processing and analysis of images, and how such issues impact on imaging the tracheobronchial tree, is essential in order to assess measurement accuracy and to make effective use of the newer methods. This article contributes to this understanding by providing a comprehensive review of current and emerging techniques for quantifying airway dimensions.KEYWORDS: Airway dimensions, confocal endomicroscopy, multidetector computed tomography, optical coherence tomography, videobronchoscopy A dvances over the past 20 yrs in medical imaging and bronchoscopy have heralded an era of unprecedented access to quantitative information on tracheobronchial structure and, increasingly, function. The expanding scope of technical advances challenges the ability of clinicians and researchers to keep abreast of recent developments and emerging techniques. Computed tomography (CT) and, to a lesser extent, bronchoscopy are the two imaging tools that have contributed most to our understanding of the airway in vivo and are used on a daily basis by clinicians in the management of airway diseases. Newer techniques, such as magnetic resonance imaging, optical coherence tomography, fibreoptic confocal endomicroscopy and endobronchial ultrasound, offer fresh insights into the way we view and quantify the airway.Over the coming years, the clinical applications of these newer techniques will be defined. As with endobronchial ultrasound, which has been adopted by interventional bronchoscopists in a little over a decade from its first reported use [1], it is likely that smoking-related lung diseases, such as bronchogenic cancer and chronic obstructive pulmonary disease (COPD), will drive the rapid development of new endoscopic imaging modalities and maintain the current pace of technical improvements of existing techniques, in particular CT. Initial applications of these techniques may focus on screening and surveillance of endobronchial malignancies and the use of real-time airway measurements during interventional procedures to deploy endobronchial stents. In these settings, accurate real-time quantitative imaging is advantageous.

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“…For example, in [12] retinal vessel width or equivalently vessel diameter was suggested as an important parameter in retinal blood flow measurement. Airway morphometry information including human airway diameters were considered for the clinical assessment of bronchoconstrictive diseases such as asthma and the associated evaluation of treatment effectiveness [13]. Tree asymmetry, a numerical index quantifying the asymmetry of a binary tree, was proposed as an effective way to detect early radiological findings in galactograms regarding breast cancer [14].…”

Section: Introductionmentioning

confidence: 99%

Classifying tree structures using elastic matching of sequence encodings

2015

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This document is the Accepted Manuscript version of the following article: Angeliki Skoura, Iosif Mporas, Vasileios Megalooikonomou, ???Classifying tree structures using elastic matching of sequence encodings???, Neurocomputing, Vol. 163, pp. 151-159, February 2015. The Version of Record is available online at: DOI: https://doi.org/10.1016/j.neucom.2014.08.083. This Manuscript version is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.Structures of tree topology are frequently encountered in nature and in a range of scientific domains. In this paper, a multi-step framework is presented to classify tree topologies introducing the idea of elastic matching of their sequence encodings. Initially, representative sequences of the branching topologies are obtained using node labeling and tree traversal schemes. The similarity between tree topologies is then quantified by applying elastic matching techniques. The resulting sequence alignment reveals corresponding node groups providing a better understanding of matching tree topologies. The new similarity approach is explored using various classification algorithms and is applied to a medical dataset outperforming state-of-the-art techniques by at least 6.6% and 3.5% in terms of absolute specificity and accuracy correspondingly

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Quantification of airway diameters and 3D airway tree rendering from dynamic hyperpolarized ³He magnetic resonance imaging

Cited by 37 publications

References 20 publications

State of the Art. A Structural and Functional Assessment of the Lung via Multidetector-Row Computed Tomography: Phenotyping Chronic Obstructive Pulmonary Disease

State of the Art. A Structural and Functional Assessment of the Lung via Multidetector-Row Computed Tomography: Phenotyping Chronic Obstructive Pulmonary Disease

Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

Classifying tree structures using elastic matching of sequence encodings

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Quantification of airway diameters and 3D airway tree rendering from dynamic hyperpolarized 3He magnetic resonance imaging

Cited by 37 publications

References 20 publications

State of the Art. A Structural and Functional Assessment of the Lung via Multidetector-Row Computed Tomography: Phenotyping Chronic Obstructive Pulmonary Disease

State of the Art. A Structural and Functional Assessment of the Lung via Multidetector-Row Computed Tomography: Phenotyping Chronic Obstructive Pulmonary Disease

Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

Classifying tree structures using elastic matching of sequence encodings

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Quantification of airway diameters and 3D airway tree rendering from dynamic hyperpolarized ³He magnetic resonance imaging