Quantification of bone healing: Comparison of QCT, SPA, MRI, and DEXA in dog osteotomies

Markel, Mark D.; Wikenheiser, Mark A.; Morin, Richard L.; Lewallen, David G.; Chao, Edmund Y.S.

doi:10.3109/17453679008993569

Cited by 57 publications

(33 citation statements)

References 29 publications

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“…Bhattacharyya et al [20] described that a CTscan has a good diagnostic accuracy (89.9 %) in the evaluation of tibial fracture healing. Also, Markel et al [21] described the benefits of the use of a CT-scan for evaluation of the local properties of bone in a dog model. Dallari et al [5] and Guerrero et al [4] used bone density measurements in their studies to score the healing of the osteotomy site.…”

Section: Discussionmentioning

confidence: 99%

No positive bone healing after using platelet rich plasma in a skeletal defect. An observational prospective cohort study

Peerbooms

Colaris

Hakkert

et al. 2012

International Orthopaedics (SICOT)

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Section: Discussionmentioning

confidence: 99%

No positive bone healing after using platelet rich plasma in a skeletal defect. An observational prospective cohort study

Peerbooms

Colaris

Hakkert

et al. 2012

International Orthopaedics (SICOT)

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“…DEXA was chosen as it is the most widely used non-invasive bone quality test used today and has excellent precision with a small radiation dose [35]. In experimental studies, DEXA has been used to evaluate the bone quality of healing fractures [9,31,32]. These studies have shown acceptable correlation of the DEXA results with mechanical properties of the healing fracture [9,31,32].…”

Section: Discussionmentioning

confidence: 99%

“…In experimental studies, DEXA has been used to evaluate the bone quality of healing fractures [9,31,32]. These studies have shown acceptable correlation of the DEXA results with mechanical properties of the healing fracture [9,31,32]. One study has also shown that DEXA scanning was able to predict the development of atrophic pseudoarthroses in a canine osteotomy model [30].…”

Section: Discussionmentioning

confidence: 99%

Fusion mass bone quality after uninstrumented spinal fusion in older patients

et al. 2010

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Older people are at increased risk of non-union after spinal fusion, but little is known about the factors determining the quality of the fusion mass in this patient group. The aim of this study was to investigate fusion mass bone quality after uninstrumented spinal fusion and to evaluate if it could be improved by additional direct current (DC) electrical stimulation. A multicenter RCT compared 40 and 100 lA DC stimulation with a control group of uninstrumented posterolateral fusion in patients older than 60 years. This report comprised 80 patients who underwent DEXA scanning at the 1 year follow-up. The study population consisted of 29 men with a mean age of 72 years (range 62-85) and 51 women with a mean age of 72 years (range 61-84). All patients underwent DEXA scanning of their fusion mass. Fusion rate was assessed at the 2 year follow-up using thin slice CT scanning. DC electrical stimulation did not improve fusion mass bone quality. Smokers had lower fusion mass BMD (0.447 g/cm 2 ) compared to non-smokers (0.517 g/cm 2 ) (P = 0.086). Women had lower fusion mass BMD (0.460 g/ cm 2 ) compared to men (0.552 g/cm 2 ) (P = 0.057). Using linear regression, fusion mass bone quality, measured as BMD, was significantly influenced by gender, age of the patient, bone density of the remaining part of the lumbar spine, amount of bone graft applied and smoking. Fusion rates in this cohort was 34% in the control group and 33 and 43% in the 40 and 100 lA groups, respectively (not significant). Patients classified as fused after 2 years had significant higher fusion mass BMD at 1 year (0.592 vs. 0.466 g/cm 2 , P = 0.0001). Fusion mass bone quality in older patients depends on several factors. Special attention should be given to women with manifest or borderline osteoporosis. Furthermore, bone graft materials with inductive potential might be considered for this patient population.

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“…Reiter et al (1997) and Maffulli et al (1997) recommended the use bone mineral density (BMD) and bone mineral content (BMC) values derived from DEXA scans to monitor bone fracture healing of femur or tibia. Markel et al (1990) assessed fracture healing after tibial osteotomies in dogs and found that DEXA had good correlations with torsional properties and calcium content of the osteotomies.…”

Section: Introductionmentioning

confidence: 99%

Effects of Eurycoma Longifolia on Fracture Healing of Androgen-Deficient Osteoporosis Model: A Micro Computed Tomograph Analysis

Shuid¹

2016

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ABSTRAK Tomografi berkomputer mikro (mikro-CT) adalah peralatan yang berguna untuk memantau pemulihan patah tulang pada model osteoporosis. Ia menyediakan imej 3D kalus fraktur yang boleh digunakan untuk mengira parameter tulang secara kuantitatif. Dalam kajian in, mikro & Health 2016;11(2): 267-277 Azri J. et al. osteoporotic fracture in males was associated with significant morbidity and has huge impact emotionally and financially on their families and the society (Johnell et al. 2001).There are three phases of fracture healing; the reactive phase, reparative phase and remodeling phase. In the reactive phase, platelets are activated to release products such as transforming growth factor-β that triggers inflammation. At the same time, haematoma is formed to seal off the fracture area (Grundnes & Reikeras 1993;Marsh & Li 1999). In the reparative phase, granulation tissue is replaced by fibrocartilage and external callus is formed by intramembranous ossification at the periosteum. Finally, in the remodeling phase, the callus and ABSTRACTMicro computed tomography (micro-CT) imaging is a useful tool to monitor fracture healing in osteoporosis model. It creates a 3-D image of the fracture callus which can be analysed to assess bone parameters quantitatively. In this study, micro-CT was used to assess the fracture healing of orchidectomised rats, an androgen-deficient osteoporosis model. The effects of Eurycoma longifolia, a medicinal plant with proandrogenic effects, on fracture healing were assessed. The rats were grouped into orchidectomised-control (ORX), sham-operated (SHAM), orchidectomised and injected with testosterone intramuscularly once weekly (TEN) and orchidectomised and daily oral gavage of Eurycoma longifolia (EL). Treatment duration was six weeks following bone fracture. Fracture was induced in the right tibia of all the rats. A total of 100 axial slices above and below fracture line were scanned with a micro-CT. The micro-CT analysis was able to detect significant difference in the fracture healing rate of ORX and TEN groups. The bridging cortices and fraction of mineralized tissue of the bridging cortices of the callous of ORX group was significantly lower than TEN group. No significant micro-CT changes were seen in the fracture healing of the EL group. The effect of EL on fracture healing was not demonstrable in orchidectomised rat model.

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Quantification of bone healing: Comparison of QCT, SPA, MRI, and DEXA in dog osteotomies

Cited by 57 publications

References 29 publications

No positive bone healing after using platelet rich plasma in a skeletal defect. An observational prospective cohort study

No positive bone healing after using platelet rich plasma in a skeletal defect. An observational prospective cohort study

Fusion mass bone quality after uninstrumented spinal fusion in older patients

Effects of Eurycoma Longifolia on Fracture Healing of Androgen-Deficient Osteoporosis Model: A Micro Computed Tomograph Analysis

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