Quantification of breath isoprene using the selected ion flow tube mass spectrometric analytical method

Španěl, Patrik; Davies, Simon; Smith, David

doi:10.1002/(sici)1097-0231(19990915)13:17<1733::aid-rcm707>3.0.co;2-s

Cited by 92 publications

(50 citation statements)

References 32 publications

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“…It was introduced for breath analysis in 1996 by Španel and Smith (Španel & Smith, ). In 1999, the quantification of isoprene in breath was shown (Španel et al, ). Many applications followed in the years after, which were reviewed in 2005 (Smith & Španel, ) and compared with proton transfer reaction mass spectrometry (PTR‐MS) (Smith & Španel, ).…”

Section: Real‐time Breath Analysismentioning

confidence: 99%

Real‐time monitoring of exhaled drugs by mass spectrometry

Berchtold

Bosilkovska

Daali

et al. 2013

Mass Spectrometry Reviews

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Future individualized patient treatment will need tools to monitor the dose and effects of administrated drugs. Mass spectrometry may become the method of choice to monitor drugs in real time by analyzing exhaled breath. This review describes the monitoring of exhaled drugs in real time by mass spectrometry. The biological background as well as the relevant physical properties of exhaled drugs are delineated. The feasibility of detecting and monitoring exhaled drugs is discussed in several examples. The mass spectrometric tools that are currently available to analyze breath in real time are reviewed. The technical needs and state of the art for on-site measurements by mass spectrometry are also discussed in detail. Off-line methods, which give support and are an important source of information for real-time measurements, are also discussed. Finally, some examples of drugs that have already been successfully detected in exhaled breath, including propofol, fentanyl, methadone, nicotine, and valproic acid are presented. Real-time monitoring of exhaled drugs by mass spectrometry is a relatively new field, which is still in the early stages of development. New technologies promise substantial benefit for future patient monitoring and treatment.

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Section: Real‐time Breath Analysismentioning

confidence: 99%

Real‐time monitoring of exhaled drugs by mass spectrometry

Berchtold

Bosilkovska

Daali

et al. 2013

Mass Spectrometry Reviews

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“…One possible overlap is of protonated isoprene C 5 20 This ion is not present in the spectra obtained when analyzing the cannabis smoke using NO + reagent ions and so we can condently label the m/z 69 ions (and its hydrates) on Fig. One possible overlap is of protonated isoprene C 5 20 This ion is not present in the spectra obtained when analyzing the cannabis smoke using NO + reagent ions and so we can condently label the m/z 69 ions (and its hydrates) on Fig.…”

Section: View Article Onlinementioning

confidence: 99%

Release of toxic ammonia and volatile organic compounds by heated cannabis and their relation to tetrahydrocannabinol content

et al. 2015

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Studies have been carried out of the compounds generated from heated "street" cannabis in the commercial device known as the "Volcano" using the selected ion flow tube mass spectrometry (SIFT-MS) analytical method. Such vaporising devices are preferred for the delivery of the cannabis active ingredients for pain relief and therapeutic purposes since they remove from the smoke the harmful high molecular weight compounds such as tars and polycyclic aromatic hydrocarbons. Whilst it is known that smoking cannabis is associated with adverse health effects, little is known about risks of its inhalation of volatile compounds from vaporizers. In the present study, the concentrations of the volatile lower molecular weight compounds ammonia, methanol, acetic acid, methyl acetate, monoterpenes and sesquiterpenes present in the trapped air/vapour volume of the "Volcano" have been determined directly by SIFT-MS obviating sample collection/pre-concentration and delayed off-line analysis as used by most other analytical techniques. The concentrations of these compounds are compared to the tetrahydrocannabinol (THC; expected to be largely D-9-THC) content of the cannabis plant material as assayed using standard extraction/derivatisation/GC-MS analysis. The observed high concentrations of ammonia were strongly correlated with the THC which is largely contained in the buds of the cannabis plant, whereas the identified volatile organic compounds were predominantly released by the leaves.Whilst the "Volcano" device removes some toxic compounds from the smoke and reduces their inhalation by its user, it likely leads to enhanced ingestion of toxic ammonia known to result in neurobehavioral impairment.

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“…Apart from giving the information required for our laboratory studies of monoterpene oxidation mechanisms, our present data also give information on the feasibility of using H 3 O + , NO + or O 2 + as primary ions for in situ detection of monoterpene oxidation products through the selected ion flow tube-mass spectrometry (SIFT-MS) method, applied by Smith and co-workers for the measurement of a number of organic compounds [31][32][33][34][35].…”

Section: O + No + or The Open Shell Cation Omentioning

confidence: 99%