The implementation of Industrial Symbiosis and Energy Efficiency is linked to the ongoing technological development. New technologies can lead to an increased up-take of these concepts, which affect all areas of process industries and involve the whole workforce. The present paper describes part of the work developed in the early stage of a current Erasmus+ project entitled “Skills Alliance for Industrial Symbiosis: A Cross-sectoral Blueprint for a Sustainable Process Industry (SPIRE-SAIS)”. Such project aims at developing an industry-driven and proactive skills strategy to assist the implementation and exploitation of Industrial Symbiosis and Energy Efficiency across the energy-intensive industrial sectors, which are represented by the association of Sustainable Process Industry through Resource and Energy Efficiency (SPIRE). The main aspects of the current state of implementation of Industrial Symbiosis and Energy Efficiency in European process industries are analyzed. In addition, upcoming techniques and developments are taken into account for the main considered sectors, e.g., Iron and Steel, Chemical, Non-ferrous Metals, Mineral, Water, Ceramics, and Cement. Achieved results on implementation of technologies and practices based on Industrial Symbiosis and Energy Efficiency, as well as new challenges coming from their accomplishments are considered. Companies’ perceptions on future implementation of Industrial Symbiosis and Energy Efficiency are explored, together with possible barriers resulting in implementation practices and expected solutions to satisfy related ongoing and future skill demands.